<i>In vivo</i> stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy

Kitayama, Yukiya; Yamada, Takuya; Kiguchi, Kentaro; Yoshida, Asami; Hayashi, Shuhei; Akasaka, Hiroaki; Igarashi, Kazunori; Nishimura, Yuya; Matsumoto, Yu; Sasaki, Ryohei; Takano, Eri; Sunayama, Hirobumi; Takeuchi, Toshio

doi:10.1039/d2tb00481j

Cited by 20 publications

(10 citation statements)

References 60 publications

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“…Similar photothermal applications were reported, such as SA-imprinted AuNRs, 110 UCPs@MIPs 111 and PB@MIP 112 utilizing different templates other than DOX. Various approaches in cancer treatment using MIP were developed, such as in chemodynamic therapy, 111,113 x-ray radiotherapy [114][115][116] and photodynamic therapy 117,118 (Figure 10).…”

Section: Applications Of Mip As Ddsmentioning

confidence: 99%

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Lawai,

Ngaini,

Farooq

et al. 2024

Polymers for Advanced Techs

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Molecularly imprinted polymer (MIP) has gained wide interest among researchers due to its unique molecular recognition of the template that is suitable as a drug carrier. Therefore, the preparation and formulation of the MIP are significant to suit the needs of the intended use. Due to its significance in drug delivery, this review aims to highlight various methods in the preparation of MIP, the composition for both controlled and stimuli‐responsive drug delivery systems, and the release mechanism of the drugs. In drug delivery systems, MIP should have a sustained release performance as well as flexibility in surface modification for targeted delivery via a range of stimuli‐responses, including external stimuli (magnetic, light) and internal stimuli (pH, temperature, redox, biological). The properties of sustained release and targeted delivery of the MIP can improve the drug's therapeutic efficacy as well as the breakthrough for the tumor targeting application.

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Section: Applications Of Mip As Ddsmentioning

confidence: 99%

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Lawai,

Ngaini,

Farooq

et al. 2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

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“…These were shown to have high selectivity towards human serum albumin and formed an albumin‐rich protein corona as well as having a passive targeting property towards refractory pancreatic cancer, based on the enhanced permeability and retention (EPR) effect. Ultimately, results showed tumour growth was suppressed more effectively in Au MIP‐NG‐injected mice compared with PBS‐injected models and that radiation therapy was successful even at a low X‐ray irradiation dose (Kitayama et al, 2022). Other studies have however showed minimal positive effect when combining hydrogels and liposomes (Billard et al, 2015) showing further work is required to understand the potential for this kind of combinational therapy.…”

Section: Bbb Dysfunction In Dementiamentioning

confidence: 99%

Blood–brain barrier disruption in dementia: Nano‐solutions as new treatment options

Cooper,

Kafetzis,

Patabendige

et al. 2023

Eur J of Neuroscience

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Candidate drugs targeting the central nervous system (CNS) demonstrate extremely low clinical success rates, with more than 98% of potential treatments being discontinued due to poor blood–brain barrier (BBB) permeability. Neurological conditions were shown to be the second leading cause of death globally in 2016, with the number of people currently affected by neurological disorders increasing rapidly. This increasing trend, along with an inability to develop BBB permeating drugs, is presenting a major hurdle in the treatment of CNS‐related disorders, like dementia. To overcome this, it is necessary to understand the structure and function of the BBB, including the transport of molecules across its interface in both healthy and pathological conditions. The use of CNS drug carriers is rapidly gaining popularity in CNS research due to their ability to target BBB transport systems. Further research and development of drug delivery vehicles could provide essential information that can be used to develop novel treatments for neurological conditions. This review discusses the BBB and its transport systems and evaluates the potential of using nanoparticle‐based delivery systems as drug carriers for CNS disease with a focus on dementia.

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“…Typically, the size of Au-based NCAs is affected by the synthesis conditions and can be optimized by adopting suitable reaction conditions (such as the pH, temperature, solvent, and ratio of reactants) . Several investigations have focused on improvement of the functionality and properties (e.g., targeting and relaxivity) of Gd-based MRI contrast agents using biocompatible Au NPs. − For instance, innovatively designed nanosystems constructed from Au NPs protected by hydrogenated ligands and decorated with Gd(III) chelates were described as MRI contrast agents, including various Au-based NCAs for MRI diagnostic applications . The crucial challenges are mainly related to the complex pharmacokinetics, possible toxicity, and clinical translation of these materials .…”

Section: Ncas For Mrimentioning

confidence: 99%

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

Soufi

Hekmatnia

Iravani

et al. 2022

ACS Appl. Nano Mater.

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Today, magnetic resonance imaging (MRI) is one of the most widely applied noninvasive clinical imaging modalities with excellent applicability in bio- and nanomedicine, particularly in specific detecting and high-quality three-dimensional imaging of tumors/cancers. In this context, the design of efficient nanoscale contrast agents (NCAs) for MRI with high magnetic relaxivity and specificity/selectivity has garnered immense interest deploying a variety of innovatively designed nanostructures. Some important characteristics of NCAs such as biocompatibility, improved relaxivity, high dispersibility, specific targeting, and low toxicity make them ideal candidates for imaging/biosensing applications. The hybridization and surface functionalization/modification of these materials by applying suitable functional groups/agents can help to improve their properties and multifunctionality. However, there is still a long way to go in the clinical applications of these nanoagents to serve as a substitute for Gd-based contrast agents or other commercial materials. Importantly, nanotoxicological and biosafety issues of these NCAs need to be systematically addressed both at pre- and clinical stages; construction of smart multifunctional NCAs with clinical diagnostic and imaging potentials is thus warranted. Herein, recent advancements related to the diagnostic and imaging applications of MRI NCAs are deliberated, focusing on important challenges and future directions.

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In vivo stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy

Abstract: Gold-nanoparticle-incorporated molecularly imprinted nanogels acquire stealth capabilities in vivo through protein corona regulation using intrinsic dysopsonic proteins. The composite can be used in radiation therapy to treat mouse pancreatic cancer.

Cited by 20 publications

References 60 publications

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Blood–brain barrier disruption in dementia: Nano‐solutions as new treatment options

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

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