<i>In vivo</i> terahertz spectroscopy of pigmentary skin nevi: Pilot study of non-invasive early diagnosis of dysplasia

Zaytsev, Kirill I.; Kudrin, Konstantin G.; Karasik, Valeriy E.; Reshetov, Igor V.; Yurchenko, Stanislav O.

doi:10.1063/1.4907350

Cited by 133 publications

(64 citation statements)

References 34 publications

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“…In a recent series of studies Zaytsev et al measured dysplastic and non-dysplastic skin nevi from four patients using in vivo THz pulsed spectroscopy and the results show that there are clear differences in the ColeCole diagrams of dysplastic and non-dysplastic skin nevi (32)(33)(34). These studies demonstrate the importance of investigating different ways to visualize the THz optical properties; in this case the imaginary part of the dielectric permittivity had less obvious differences between dysplastic and no-dysplastic nevi than the real part.…”

Section: In Vivo Imaging and Spectroscopymentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

230

113

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Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images. This short review highlights some of the recent work in these areas and suggests some future research directions.

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Section: In Vivo Imaging and Spectroscopymentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

230

113

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“…Moreover, THz-wave scattering on the surface and in the volume of the tissue sample prevents accurate reconstruction at higher frequencies [60]. Thereby, we do not show the reconstruction results in these frequency ranges.…”

Section: Verification Of the Methodsmentioning

confidence: 66%

“…All the methods to noninvasively diagnose skin cancers [37]- [40], [60], [61] and burns [56]- [59] based on THz absorption spectroscopy, as well as all the approaches for principal component analysis [40], [60], should be adjusted to account for the variations of the THz refractive index and absorption coefficient along the human body.…”

Section: Measuring the Variation Of Refractive Index And Absorbtimentioning

confidence: 99%

“…The use of TPS for sensing in corneal tissue [50], dental tissue [51], [52], and blood [53]- [55], as well as for studying thermal and chemical tissue burns [56]- [59], has been studied. In [60] and [61], the ability to noninvasively diagnose dysplastic skin nevi has been demonstrated; this is of importance since the dysplasia of skin nevi is considered to be a melanoma precursor, which is reportedly the most dangerous skin cancer [62], [63]. Despite the wide variety of biomedical applications of TPS, the development of novel methods for TPS signal processing and the inverse problem solution is of great importance for further progress of TPS technology.…”

Section: Introductionmentioning

confidence: 99%

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Highly Accurate in Vivo Terahertz Spectroscopy of Healthy Skin: Variation of Refractive Index and Absorption Coefficient Along the Human Body

Zaytsev

Gavdush

Chernomyrdin

et al. 2015

IEEE Trans. THz Sci. Technol.

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A method to reconstruct the terahertz (THz) refractive index and absorption coefficient of in vivo tissue using THz pulsed spectroscopy (TPS) has been proposed. The method utilizes a reference THz window to fix the sample of interest during the TPS reflection mode measurements. Satellite pulses caused by multiple THz-wave reflections in the reference window are taken into account to accurately solve the inverse problem. The stability of the proposed method in the presence of various factors, including digital noise in the TPS waveforms and fluctuations of the reference THz window position, has been accurately analyzed. The method has been implemented to study in vivo the THz refractive index and absorption coefficient of the human skin. The skin from three persons has been measured, and the results agree with the well-known data on healthy skin spectroscopy in general, except for several regions of the skin. Thus, for the elbow, the hand, the knee, and the heel the THz refractive index and absorption coefficient considerably differ from the average values. The observed results are of principle importance for further development of novel approaches to skin diagnosis based on THz technologies.Index Terms-Absorption coefficient, inverse problem, material parameters, refractive index, spectroscopy of the skin, terahertz pulsed spectroscopy, THz technology.

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“…15 THz-TDS systems are powerful tools for material spectroscopy, layer inspection, and transmission imaging of packaged objects. 16 These capabilities of THz-TDS systems are utilized in authentication, [17][18][19] nondestructive inspection of composite materials, [20][21][22][23][24][25][26][27][28] threedimensional imaging, [29][30][31][32] metrology and quality control of industrial products, [33][34][35][36][37] detection of concealed weapons, [38][39][40][41][42][43][44][45] art investigations, 46,47 tomography, [48][49][50][51][52] biomedical diagnosis, [53][54][55][56] material characterization, [57][58][59][60][61][62] thickness measurement, …”

Section: Introductionmentioning

confidence: 99%

Review of GaN-based devices for terahertz operation

Ahi

2017

Opt. Eng

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Abstract. GaN provides the highest electron saturation velocity, breakdown voltage, operation temperature, and thus the highest combined frequency-power performance among commonly used semiconductors. The industrial need for compact, economical, high-resolution, and high-power terahertz (THz) imaging and spectroscopy systems are promoting the utilization of GaN for implementing the next generation of THz systems. As it is reviewed, the mentioned characteristics of GaN together with its capabilities of providing high two-dimensional election densities and large longitudinal optical phonon of ∼90 meV make it one of the most promising semiconductor materials for the future of the THz emitters, detectors, mixers, and frequency multiplicators. GaNbased devices have shown capabilities of operation in the upper THz frequency band of 5 to 12 THz with relatively high photon densities in room temperature. As a result, THz imaging and spectroscopy systems with high resolution and deep depth of penetration can be realized through utilizing GaN-based devices. A comprehensive review of the history and the state of the art of GaN-based electronic devices, including plasma heterostructure field-effect transistors, negative differential resistances, hetero-dimensional Schottky diodes, impact avalanche transit times, quantum-cascade lasers, high electron mobility transistors, Gunn diodes, and tera field-effect transistors together with their impact on the future of THz imaging and spectroscopy systems is provided.

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In vivo terahertz spectroscopy of pigmentary skin nevi: Pilot study of non-invasive early diagnosis of dysplasia

Cited by 133 publications

References 34 publications

Recent advances in terahertz technology for biomedical applications

Recent advances in terahertz technology for biomedical applications

Highly Accurate in Vivo Terahertz Spectroscopy of Healthy Skin: Variation of Refractive Index and Absorption Coefficient Along the Human Body

Review of GaN-based devices for terahertz operation

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