2024
DOI: 10.1101/2024.05.24.595782
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In vivotracking ofex vivogenerated89Zr-oxine labeled plasma cells by PET in a non-human primate model

David J Young,
Abigail J Edwards,
Kevin G Quiroz Caceda
et al.

Abstract: B cells are an attractive platform for engineering to produce protein-based biologics absent in genetic disorders, and potentially for the treatment of metabolic diseases and cancer. As part of pre-clinical development of B cell medicines, we demonstrate a method to collect,ex vivoexpand, differentiate, radioactively label, and track adoptively transferred non-human primate (NHP) B cells. These cells underwent 10- to 15-fold expansion, initiated IgG class switching, and differentiated into antibody secreting c… Show more

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