<i>In vivo</i> wound healing and antibacterial performances of electrospun nanofibre membranes

Liu, Xin; Lin, Tong; Fang, J.; Yao, Gang; Zhao, Hongqiong; Dodson, Michael V.; Wang, Xungai

doi:10.1002/jbm.a.32718

Cited by 186 publications

(143 citation statements)

References 27 publications

(59 reference statements)

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“…The current aim is to develop systems that not only target various components of the wound healing process (i.e., anti-inamma-tory and antibacterial activity) but also provide an adjustable and controlled release of multiple drugs. 119 The amount and progression (be that simultaneous or a stepwise release) of drugs will be determined by the stage of the healing wound.…”

Section: Emerging Nanober Mats That Strategically Target Multiple Famentioning

confidence: 99%

Designing electrospun nanofiber mats to promote wound healing – a review

2013

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Current strategies to treat chronic wounds offer limited relief to the 7.75 million patients who suffer from burns or chronic skin ulcers. Thus, as long as chronic wounds remain a global healthcare problem, the development of alternate treatments remain desperately needed. This review explores the recent strategies employed to tailor electrospun nanofiber mats towards accelerating the wound healing process. Porous nanofiber mats readily produced by the electrospinning process offer a promising solution to the management of wounds. The matrix chemistry, surface functionality, and mat degradation rate all can be fine-tuned to govern the interactions that occur at the materials-biology interface. In this review, first we briefly discuss the wound healing process and then highlight recent advances in drug release, biologics encapsulation, and antibacterial activity that have been demonstrated via electrospinning. While this versatile biomaterial has shown much progress, commercializing nanofiber mats that fully address the needs of an individual patient remains an ambitious challenge.

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Section: Emerging Nanober Mats That Strategically Target Multiple Famentioning

confidence: 99%

Designing electrospun nanofiber mats to promote wound healing – a review

2013

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“…40,41 It is also possible to use functionalized solvents to carry charge. 42 All of these routes allow the formation of perfluorinated fibers on one step, although any other fibers can be treated in a second step coating a finished mat.…”

Section: Electrospinningmentioning

confidence: 99%

The superhydrophobicity of polymer surfaces: Recent developments

Shirtcliffe

McHale

Newton

2011

J Polym Sci B Polym Phys

168

108

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Superhydrophobicity is the extreme water repellence of highly textured surfaces. The field of superhydrophobicity research has reached a stage where huge numbers of candidate treatments have been proposed and jumps have been made in theoretically describing them. There now seems to be a move to more practical concerns and to considering the demands of individual applications instead of more general cases. With these developments, polymeric surfaces with their huge variety of properties have come to the fore and are fast becoming the material of choice for designing, developing, and producing superhydrophobic surfaces.

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“…The air permeability is one of the important parameters of wound dressings, which prevents maceration and (2) gives a better comfort to the patients. In a recent in vivo study on wound healing and antibacterial performance of electrospun nano fibre membranes, the authors concluded that the porosity and air permeability characteristics have a strong influence on facilitating the wound healing, especially at the early healing stages (3). It can also be noticed from the data in Table 1 that the air-permeability values of the fabrics increased when the fabrics' area densities decreased.…”

Section: Flexural Rigidity and Air Permeabilitymentioning

confidence: 96%

Thermal Conformability of Developed Fibrous Wound Dressings

Uzun¹,

An²,

Shah³

2017

JTEFT

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Alambeta:The thermo physiological properties of the nonwoven fabrics were determined by using the Alambeta and Permetest instruments (Sensora Instruments, Czech Republic). The Alambeta instrument provides values for thermal conductivity, thermal resistance (insulation), thermal absorptivity (warmth-to-touch), fabric thickness and thermal diffusivity as shown in Figure 1. The test instrument was used to analyse the transient and steady state thermo physical properties of the fabrics. The specimens of 20cm×20cm were prepared and placed in between two plates. With the two plates the heat flow through the fabric due to the different temperature of the bottom measuring plate (at ambient temperature) and the top measuring plate which is heated to 40˚C. The thermal absorptivity of the textile structure is a measure of the amount of heat conducted away from structure's surface per unit time (1). The test was performed on the dry and wet states of the nonwoven fabrics which were wetted with 0.2ml of distilled water in the centre of the fabrics and allowed 4 minutes before retesting, in order to allow for the thermal recovery of the fabric. All the tests were carried out on both faces of each specimen and the mean values were calculated. 1,2Permatest: The water vapour permeability and the resistance to evaporative heat loss of the fabrics were tested by using the Permetest Instrument, Sensora Instruments, and Czech Republic in Figure 2. This instrument is based on the skin model, which simulates dry and wet human skin surface in terms of its moisture, water vapour and evaporative heat permeation. The instrument uses the same principle as specified in ISO 11092 developed by Hohenstein Institute, whereby a heated porous membrane is used to simulate the sweating skin. The heat required for the water to evaporate from the membrane, with and without a fabric covering, is measured (1). A heated porous membrane is used to simulate sweating skin. A current of air removes the micro-climate that develops above the surface of the membrane. The heat required evaporating the water from the membrane with and without a test fabric covering is measured. The fabric produces resistance to evaporation and therefore less heat is required. The results are used to calculate the relative water vapour permeability as a percentage of the control test without the fabric covering, and the resistance to evaporative heat loss in m 2 PaW -1 . The specimens that were used for measuring the thermal properties in the Alambeta instrument were also used for testing on the Permatest apparatus. AbstractA novel concept, based on collagen boosting agent treatment, has been explored in this study, wherein the developed nonwoven structures were treated with two different collagen promoting agents Vitamin C and zinc oxide (ZnO) at 0.5% and 3% levels by using a spray method. With the rapid demand of modern and smart wound dressings, it is vital that an effort has to be made to develop novel wound dressings by making use of known collagen promoting agents to enhan...

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In vivo wound healing and antibacterial performances of electrospun nanofibre membranes

Cited by 186 publications

References 27 publications

Designing electrospun nanofiber mats to promote wound healing – a review

Designing electrospun nanofiber mats to promote wound healing – a review

The superhydrophobicity of polymer surfaces: Recent developments

Thermal Conformability of Developed Fibrous Wound Dressings

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