<i>Interleukin-17A</i>rs2275913<i>, Interleukin-17F</i>rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis

Hammad, Ayman; Mosaad, Youssef M.; Hammad, Enas; Elhanbly, Samir; El-Bassiony, Sherif R.; Al-Harrass, Mohammad; Eid, Riham; Eldein, Omar A. Sharaf; Alsawah, Gehan Attia; Yahia, Sohier; Fawzy, Iman M.

doi:10.3109/08916934.2015.1101071

Cited by 35 publications

(28 citation statements)

References 41 publications

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“…Discrepancies in genotype frequencies between reports may be explained by the heterogeneity of the analyses diseases, distinct ethnicities as well as limited sample size. Moreover, the other two SNPs -IL-17F rs2397084 A/G and IL-23R rs10489629 G/A were not observed to be associated with SLE, whit is a concordance with others studies [14][15][16][17][18][19]. The results of this study showed also no significant differences between SLE patients and control subjects in genotypes distribution and allele frequencies for the IL-23A rs11171806 G/A polymorphism.…”

Section: Discussionsupporting

confidence: 89%

“…Structural, quantitative, or regulatory polymorphisms at the IL-17F, IL-23A and/or IL-23R locus may lead to an incorrect of functional Th17 cells and contribute to the susceptibility to some autoimmune conditions. The IL-17F and IL-23R gene polymorphisms, including all examined here have been studied in different ethnic group [14][15][16][17][18]. The results of this study showed significant differences between SLE patients and healthy subjects in genotype distribution and allele frequencies for the IL-23R rs1884444 G/T and IL-17F rs763780 A/G polymorphisms.…”

Section: Discussionmentioning

confidence: 69%

“…Because the polymorphic allele of the IL-23R rs1884444 T and the polymorphic allele of the IL-17F rs763780 G were more frequently observed in SLE patients than in controls, we can assume that both these polymorphisms may be considered as genetic marker for SLE in the Polish population. In contrast, a study on Chinese [16,19] and Egyptian [14] populations found no association between the IL-23R rs1884444 G/T and IL-17F rs763780 A/G genetic variants and SLE, respectively. Discrepancies in genotype frequencies between reports may be explained by the heterogeneity of the analyses diseases, distinct ethnicities as well as limited sample size.…”

Section: Discussionmentioning

confidence: 75%

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Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus

et al. 2016

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Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and controls, were examined for IL-23A rs11171806 G/A and IL-23R (rs1884444 G/T, rs10489629 G/A) by TaqMan SNP genotyping assay, for IL-17F rs763780 A/G and rs2397084A/G using the PCR- RFLP method. An increased frequency of AG genotype as well as G allele of the IL-17F rs763780 was found in patients with SLE, as compared with healthy subjects (OR = 3.947; p = 0.001 and OR = 3.538; p = 0.002, respectively). Frequencies of the rs1884444 TT genotype (OR = 138.1) and the rs1884444 T allele (OR = 2.176) were also higher in SLE patients (both p < 0.0001). Overall, weak LD was observed between the IL-17F rs763780 A/G and rs2397084 A/G polymorphisms (D'-0.003, r - 0.000). From four possible haplotypes, frequencies of AG showed differences between both examined groups (p < 0.0001). We also observed a weak LD between the IL-23R rs10489629G/A and rs1884444 G/T (D'-0.199, r -0.026). The genotype-phenotype analysis showed significant association between the IL-17F rs2397084 and mean value of the hemoglobin (p = 0.01), the IL-17F rs763780 and age (p = 0.008) and lupus anticoagulant (p = 0.09), the IL-23 rs11171806 and urea (p = 0.08) and C3 complement (p = 0.03), and the IL-23R rs1884444 G/T and activated partial thromboplastin time (p = 0.06). Present findings indicated that IL-17F rs763780 A/G and IL-23R rs1884444 G/T polymorphisms may be involved in susceptibility to SLE in the Polish population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 75%

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Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus

et al. 2016

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“…The AA genotype of the rs2275913 SNP of the IL‐17A gene is reportedly associated with a higher risk of asthma, bronchiolitis, ulcerative colitis, digestive cancer, gastric cancer, and cervical cancer . Other studies reported that the rs2275913 SNP had no association with pediatric systemic lupus erythematosus disease activity or cervical cancer and had opposite effects on rheumatoid arthritis, post‐bronchiolitis asthma at 11‐13 years of age and colorectal cancer . Overall, the AA genotype of the rs2275913 SNP appears to contribute to greater inflammation, leading to autoimmune‐related inflammatory diseases, including cancer.…”

Section: Introductionmentioning

confidence: 99%

Association between rs2275913 single‐nucleotide polymorphism of the interleukin‐17A gene and perioperative analgesic use in cosmetic orthognathic surgery

Ohka

Nishizawa

Hasegawa

et al. 2018

Neuropsychopharm Rep

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Aim: Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers. Methods:The present study used a correlational design to examine the impact of the rs2275913 SNP on postoperative pain-related phenotypes in a group of patients who underwent cosmetic orthognathic surgery.Results: Carriers of the AA genotype had higher opioid requirements during and after surgery than carriers of the AG and GG genotypes (P = .009). Linear regression analysis indicated that opioid requirements linearly increased as the copy number of the A allele of the SNP increased (P = .008). Conclusions:Opioid requirements during and after surgery are enhanced in carriers of the AA genotype of the rs2275913 SNP of the IL-17A gene, possibly through an enhancement of IL-17A function that induces inflammation that is related to the inflammatory pain stimulus.analgesics, human, IL17A protein, opioid, orthognathic surgery, pain, polymorphism, postoperative, single-nucleotide Ohka and Nishizawa contributed equally to this work.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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“…IL17A is the hallmark of Th17 response and its gene is located on chromosome 6p12.1 and contains three exons and two introns (Liu et al., ). IL17A G197A (rs2275913) is the most studied IL17A SNP and had been associated with a higher susceptibility to several systemic diseases such as gastric cancer (Liu et al., ), Crohn's disease and ulcerative colitis (Zhang et al., ), juvenile systemic lupus erythematosus (Hammad et al., ), and pulmonary tuberculosis (Shi & Zhang, ), but little is known regarding its role in oral diseases.…”

Section: Introductionmentioning

confidence: 99%

IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

et al. 2017

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Interleukin-17Ars2275913, Interleukin-17Frs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis

Cited by 35 publications

References 41 publications

Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus

Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus

Association between rs2275913 single‐nucleotide polymorphism of the interleukin‐17A gene and perioperative analgesic use in cosmetic orthognathic surgery

IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus

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