Interleukin-18 Gene Polymorphisms in Egyptian Patients with Allergic Diseases

Ibrahim, Gehan H.; ElTabbakh, Mohammed T.; Gomaa, Amal H. A.; Mohamed, Eman A.

doi:10.2500/ajra.2012.26.3806

Cited by 19 publications

(14 citation statements)

References 37 publications

(72 reference statements)

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“…The studies identified and their main characteristics were summarized in Table 1. Of the 21 case-control studies included, an array of allergic diseases including AA [31–40], AD [41–45], AR [10, 46], drug allergy [47, 48], and other types [49, 50] was involved. Of all studies included, 12 studies were conducted in Asian populations [31, 33, 36, 37, 39, 40, 43–48], while 9 studies were performed in Caucasian populations [10, 32, 34, 35, 38, 41, 42, 49, 50].…”

Section: Resultsmentioning

confidence: 99%

“…Of the 21 case-control studies included, an array of allergic diseases including AA [31–40], AD [41–45], AR [10, 46], drug allergy [47, 48], and other types [49, 50] was involved. Of all studies included, 12 studies were conducted in Asian populations [31, 33, 36, 37, 39, 40, 43–48], while 9 studies were performed in Caucasian populations [10, 32, 34, 35, 38, 41, 42, 49, 50]. There were 16 studies concerning IL-18 −607C/A [10, 31, 32, 35–40, 44–50] and 19 studies concerning −137G/C [10, 31–37, 39–45, 47–49].…”

Section: Resultsmentioning

confidence: 99%

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The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

Cheng

Hao

Zhou

et al. 2014

BioMed Research International

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Recent studies have suggested that IL-18 −607C/A and −137G/C polymorphisms may be associated with the risk of allergic disease; however, individually published results are inconclusive. Therefore, we performed a meta-analysis to clarify whether IL-18 −607C/A and −137G/C polymorphisms were associated with the risk of allergic disease. A total of 21 studies including 5,331 cases and 9,658 controls were involved in this meta-analysis. In the overall analysis and the subgroup analysis according to ethnicity, we did not find significant association between IL-18 −607C/A or −137G/C polymorphism and the risk of allergic disease (all P > 0.05). However, in a stratified analysis by type of allergic disease, our results indicated that IL-18 −607C/A polymorphism was associated with a significantly decreased risk of allergic asthma in heterozygous comparison and IL-18 −137G/C was associated with a significantly decreased risk of allergic dermatitis in recessive model and homozygous comparison. In the stratified analysis by source of control, IL-18−607C/A showed significantly reduced risk in population-based subgroup, and for IL-18 −137G/C only significantly decreased risk was found in the hospital-based subgroup. Our meta-analysis suggests that IL-18 −607C/A and −137G/C polymorphisms may be protective factors for the risk of allergic asthma and allergic dermatitis, respectively.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

Cheng

Hao

Zhou

et al. 2014

BioMed Research International

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“…AR is an inflammatory disease of the nasal mucosa induced by an immunoglobulin E (Helbling et al, 2014)-mediated reaction in allergen-sensitized individuals. It has been reported that numerous loci and candidate genes show an association with AR (Gaddam et al, 2012;Genuneit et al, 2009;Ibrahim et al, 2012;Tomazic et al, 2014). In spite of that, the molecular mechanisms underlying the development of AR have not been completely determined.…”

Section: Introductionmentioning

confidence: 94%

IL-23, rather than IL-17, is crucial for the development of ovalbumin-induced allergic rhinitis

Guo

Chen

2015

Molecular Immunology

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“…Figure 1 outlines the study selection process in a PRIS-MA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)-sanctioned flowchart. Initial search resulted in 20 citations, followed by a series of omissions that eventually yielded 8 articles for inclusion [35][36][37][38][39][40][41][42]. Of the 8 included articles, 6 [35,[38][39][40][41][42] were not included in the previous meta-analysis on the same topic [21].…”

Section: Meta-analysismentioning

confidence: 99%

Influence of Polymorphisms in the Interleukin-18 Gene on Allergic Rhinitis: A Meta-Analysis

Tharabenjasin

Pabalan

Jarjanazi

et al. 2020

Int Arch Allergy Immunol

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Purpose: Reported associations of interleukin-18 (IL-18) single-nucleotide polymorphisms (SNPs) with allergic rhinitis (AR) have been inconsistent, prompting a meta-analysis to obtain more precise estimates. Methods: We synthesized data from 8 articles and examined 3 IL-18 SNPs. Two SNPs (rs360721 and rs187238), in linkage disequilibrium, were combined and termed RS1. The rs1946518 SNP was analyzed separately (termed RS2). The recessive, dominant, and codominant (multiplicative) genetic models were used to estimate ORs and 95% CIs. Subgroup analysis was ethnicitybased. Sources of heterogeneity were investigated with outlier treatment. Sensitivity analysis was used to assess robustness of the associative effects. Multiple comparisons were Holm-Bonferroni corrected. Results: All significant (p a < 0.05) outcomes indicating increased risks were found in the dominant/codominant models in RS1 and RS2. Five aspects of differences marked the significant African (RS1) and overall (RS2) outcomes: (i) magnitude of effect (ORs): greater (3.01-5.15) versus less (1.20-1.47); (ii) precision of effects (95% CIs): less (1.07-21.52) versus more (1.01-1.89); (iii) outlier treated: no versus yes; (iv) sensitivity outcomes: nonrobust versus robust (dominant model only); and (v) greater evidential strength for RS2 (p a = 0.002) compared to RS1 (p a = 0.02) rendered RS2 our core finding. These levels of statistical significance for RS1/RS2 enabled both to survive the Holm-Bonferroni correction. Conclusions: The core outcome indicating a 1.5-fold increased risk could render the IL-18 polymorphisms useful in the clinical genetics of AR. Future studies that could focus on other IL-18 SNPs may find deeper associations with AR than what we found here.

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Interleukin-18 Gene Polymorphisms in Egyptian Patients with Allergic Diseases

Abstract: This preliminary study indicates that the studied polymorphisms do not confer susceptibility to allergy in Egyptian patients but may be related to the disease phenotype. However, the role of IL-18 in allergy may be too complex to be reflected in a simple association study.

Cited by 19 publications

References 37 publications

The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

The Relationship between Interleukin-18 Polymorphisms and Allergic Disease: A Meta-Analysis

IL-23, rather than IL-17, is crucial for the development of ovalbumin-induced allergic rhinitis

Influence of Polymorphisms in the <b><i>Interleukin-18</i></b> Gene on Allergic Rhinitis: A Meta-Analysis

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