Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk

Abstract

Epidemiological studies have suggested that interleukin-17 (IL-17) polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association of the IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms with cancer risk. Publication bias and sensitivity analyses were performed to ensure the statistical power. Overall, 10 relevant case-control studies involving 4,516 cases and 5,645 controls were included. The pooled ORs with 95% CIs indicated that the IL-17A rs2275913G>A polymorphism was significantly associated with increased cancer risk (for A versus G: OR = 1.28, 95% CI: 1.16–1.41, P < 0.001, I 2 = 61.1%; for GA versus GG: OR = 1.12, 95% CI: 1.02–1.23, P = 0.015, I 2 = 27.8%; for AA versus GG: OR = 1.71, 95% CI: 1.38–2.41, P < 0.001, I 2 = 69.6%; for GA + AA versus GG: OR = 1.23, 95% CI: 1.13–1.34, P < 0.001, I 2 = 6.4%; for AA versus GG + GA: OR = 1.62, 95% CI: 1.27–2.07, P < 0.001, I 2 = 81.4%). Succeeding analysis of HWE and stratified analysis of gastric cancer and the Asian (and Chinese) population revealed similar results. The IL-17F rs763780T>C polymorphism was also significantly associated with gastric cancer development. Overall, the present meta-analysis suggests that IL-17 polymorphisms increase the risk of developing cancer, particularly gastric cancer, in the Asian (and Chinese) population.

Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis

“…A meta-analysis by Niu et al 42 suggested that IL-17 polymorphisms increase the risk of cancer, particularly gastric cancer, in Asian (especially Chinese) populations; our findings were partially in line with results from this meta-analysis. Another meta-analysis by Zhao et al 43 concluded that not rs763780, but rs2275913, polymorphism may contribute to cancer susceptibility in Asian populations.…”

Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan

“…Four SNPs across IL-17A, viz., rs8193036(C > T), rs8193037(G > A), rs2275913(G > A), and rs3748067(C > T) loci, located in the promoter region or 3′ UTR were examined in this study due to their considerable associations with various malignancies, including NSCLC, and chronic inflammatory respiratory diseases, such as chronic obstructive pulmonary disease, in previous studies [ 18 , 19 , 20 , 26 , 27 ]. Peripheral blood samples from LUAD patients were collected in EDTA-containing tubes for genomic DNA extraction using the QIAamp DNA Blood Mini kit (Qiagen).…”

“…Single nucleotide polymorphisms (SNPs) are common types of genetic variations in the genome which can alter the function and expression of coding genes associated with risks of developing certain cancers. Previous studies disclosed that IL-17A SNPs can affect the risk of cancer development and progression through influencing IL-17A expression in various malignancies including NSCLC [ 18 , 19 , 20 ]. Previously, cancer-related SNPs and somatic mutations were independently studied.…”

Association Study of rs763780T>C IL-17F and rs2275913G>A IL-17A Polymorphisms with Breast Cancer Risk in East Azerbaijan-Iran

“…One of the studied genes in this regard is the IL-17 gene, which suggests that its polymorphism is associated with the risk of BC (4). The main role of IL-17 is response to inflammation, yet it also plays a role in the early stages of tumorigenesis and early formation of tumor (5).…”