<i>Inula viscosa</i> ameliorates acetic acid induced ulcerative colitis in rats

Cellat, Mustafa; Tekeli, İbrahim Ozan; Türk, Erdinç; Aydin, Tuba; Uyar, Ahmet; İşler, Cafer Tayer; Gökçek, İ̇shak; Etyemez, Muhammed; Güvenç, Mehmet

doi:10.1080/10520295.2023.2176923

Biotechnic & Histochemistry

2023

DOI: 10.1080/10520295.2023.2176923

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Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats

Mustafa Cellat

İbrahim Ozan Tekeli

Erdinç Türk

et al.

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2024

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Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?

Xavier,

Reis,

Martins

et al. 2024

Antioxidants

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Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web of Science, EMBASE, and Scopus using keywords like “Inflammatory Bowel Diseases” and “Antioxidants.” Initially, 925 publications were identified, and after applying inclusion/exclusion criteria—covering studies from July 2015 to June 2024 using murine models or clinical trials in humans and evaluating natural or synthetic substances affecting oxidative stress markers—368 articles were included. This comprised 344 animal studies and 24 human studies. The most investigated antioxidants were polyphenols and active compounds from medicinal plants (n = 242; 70.3%). The review found a strong link between oxidative stress and inflammation in IBD, especially in studies on nuclear factor kappa B and nuclear factor erythroid 2-related factor 2 pathways. However, it remains unclear whether inflammation or oxidative stress occurs first in IBD. Lipid peroxidation was the most studied oxidative damage, followed by DNA damage. Protein damage was rarely investigated. The relationship between antioxidants and the gut microbiota was examined in 103 animal studies. Human studies evaluating oxidative stress markers were scarce, reflecting a major research gap in IBD treatment. PROSPERO registration: CDR42022335357 and CRD42022304540.

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Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?

Xavier,

Reis,

Martins

et al. 2024

Antioxidants

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show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats

Cited by 1 publication

References 57 publications

Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?

Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?

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