IRGM gene polymorphisms and risk of gastric cancer

Abstract

IRGM rs4958847 polymorphism influences susceptibility to gastric cancer, mainly for the intestinal type.

Autophagy in Helicobacter pylori Infection and Related Gastric Cancer

“…To date, only one study has addressed the association between this polymorphism and GC. In agreement with our findings, Burada et al [19], analyzing 102 GC patients, 52 chronic gastritis patients and 351 healthy controls from Romania, found IRGM rs4958847 to significantly decrease the risk of GC in this Caucasian population (OR: 0.58, 95% CI: 0.35-0.97, p-value: .038). Interestingly, similar to ATG16L1 rs2241880, there have been attempts to associate IRGM rs4958847 with CD pathogenesis.…”

“…In addition, IFN-c has been shown to inhibit gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis in a murine model [18]. Interestingly, investigation of the association between IRGM polymorphisms (rs4958847 and rs13361189) and GC in a Caucasian population by Burada et al [19] has shown IRGM rs4958847 to decrease the risk of GC in these individuals. IRGM is located at chromosome 5q33.1 and encodes the immunity-related GTPase family M protein (IRGM), an IFN-inducible GTPase that is involved in autophagic vacuole formation.…”

Dynamins and BAR Proteins-Safeguards against Cancer

“…79 IRGM null mice are extremely susceptible to bacterial infection 80 and mutations in IRGM are linked to Helicobacter Pylori infection and gastric inflammation, which may ultimately lead to gastric cancer. 81 Polymorphism in the IRGM gene has also been linked to Chron's disease, which is often the cause of colorectal cancer. 80 IRGM is linked to apoptosis and autophagy, though its exact mechanism or role in these processes is not known.…”

IRGM in autophagy and viral infections

“…In African American populations one CD-related polymorphism was associated positively with TB suggesting a possible link between CD and an infectious etiology. Irgm polymorphism is possibly also a risk factor for gastric cancer (Burada et al, 2012). Although deregulation of autophagy is well established to be associated with cancer (White, 2012), a role for IRGM in these diseases has to be further determined.…”