<i>Klebsiella pneumoniae</i>Antimicrobial Drug Resistance, United States, 1998–2010

Sánchez, Guillermo; Master, Ronald N.; Clark, Richard B.; Fyyaz, Madiha; Duvvuri, Padmaraj; Gupta, Ekta; Bordón, José

doi:10.3201/eid1901.120310

Cited by 129 publications

(91 citation statements)

References 14 publications

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“…In recent decades, due to its tendency to develop antibiotic resistance and increasing virulence factor, lead to emerging this bacterium as clinically important organism [4,5]. Klebsiella pneumoniae strains commonly have different types of beta-lactamase enzymes such as extended-spectrum beta-lactamases (ESBLs), AmpC beta-lactamases, and carbapenemases, which confer resistance to different types of beta-lactam antibiotics [6]. The AmpC beta-lactamases are particularly troublesome group because can easily be transmitted by conjugation to other bacteria, which has increased incidence worldwide [7].…”

Section: Introductionmentioning

confidence: 99%

First report of coexistence of AmpC beta-lactamase genes in Klebsiella pneumoniae strains isolated from burn patients

Ghanavati

Darban-Sarokhalil

Navab-Moghadam

et al. 2017

AMicr

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Klebsiella spp. are among the most frequently isolated bacteria from burn wounds. These organisms are among the most important opportunistic pathogens, causing hospital-acquired and healthcare-associated infections worldwide. Limited information is available about prevalence of AmpC-producing Klebsiella pneumoniae from burn patients. Therefore, the aim of this study was to determine the characterization of AmpC beta-lactamase among K. pneumoniae isolated from burn patients. Samples were collected from wound specimens of patients with burn injury from a burn hospital in Tehran during 18 months (March 2015 to August 2016). For phenotypic detection of AmpC beta-lactamase, disk diffusion method with cefoxitin was used for screening, AmpC disk test and boronic acid inhibitor-based method were used as confirmatory tests. Polymerase chain reaction (PCR) was performed to screen all isolates with AmpC genes including ACCM, DHAM, EBCM, FOXM, MOXM, and CITM. Finally, PCR products were validated using sequencing. During this study, 102 isolates of K. pneumoniae were collected. Among these isolates, 52.9% suspected as AmpC producer by disk agar diffusion cefoxitin screening method. By confirmatory phenotypic methods, 19.6% of isolates considered as AmpC producer. Molecular analysis revealed 43.1% of cefoxitin-resistant isolates harbored at least one of the AmpC genes including CITM (22.5%), EBCM (21.5%), DHAM (7.8%), and FOXM (0.98%). In addition, 5.8% of isolates harbored two AmpC genes and 2.9% harbored three AmpC genes. In conclusion, K. pneumoniae is becoming a serious problem in burn patients. Accurate and precise methods and guidelines should be designed for detection of antibiotic-resistant mechanisms. Our data showed the high rate of AmpC beta-lactamase among K. pneumoniae isolated from burn patients, which limit the treatment options. Therefore, the results of this study can provide evidence to help for appropriate treatment of burn patients.

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Section: Introductionmentioning

confidence: 99%

First report of coexistence of AmpC beta-lactamase genes in Klebsiella pneumoniae strains isolated from burn patients

Ghanavati

Darban-Sarokhalil

Navab-Moghadam

et al. 2017

AMicr

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“…Additionally, strains with progressive reductions in antibacterial drug susceptibility have been isolated in different countries (2) (3) . Since the end of the 20 th century, strains have been disseminated with simultaneous resistance to various antimicrobial classes mediated by the production of extended spectrum beta-lactamases (ESBL), loss of porins, and later also by the production of carbapenemases and metallo-betalactamases (4) (5) .…”

mentioning

confidence: 99%

Secular trends in Klebsiella pneumoniae isolated in a tertiary-care hospital: increasing prevalence and accelerated decline in antimicrobial susceptibility

Santana

Gaspar

Vilar

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…Klebsiella pneumoniae is among the leading pathogens causing nosocomial pneumonia and the treatment of its infection is restricted to a few number of therapeutic approaches (Hirsch and Tam, 2010;Sanchez et al, 2013). First described by Friedlander as an encapsulated bacilli isolated from a case of pneumonia in 1882 (Friedlaender, 1882), Klebsiella pneumoniae is a gram negative bacterial pathogen that has great clinical relevance because of the progressive development of evasion mechanisms to therapeutic strategies available today (Kumarasamy et al, 2010;Sanchez et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Intradermal Immunization of BALB/C Mice with Heat Killed Klebsiella pneumoniae ATCC BAA1706 Leads to the Production of both IgG1 and IgG2a

Pereira¹,

Galantine²,

Muniz³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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Klebsiella pneumoniaeAntimicrobial Drug Resistance, United States, 1998–2010

Cited by 129 publications

References 14 publications

First report of coexistence of AmpC beta-lactamase genes in Klebsiella pneumoniae strains isolated from burn patients

First report of coexistence of AmpC beta-lactamase genes in Klebsiella pneumoniae strains isolated from burn patients

Secular trends in Klebsiella pneumoniae isolated in a tertiary-care hospital: increasing prevalence and accelerated decline in antimicrobial susceptibility

Intradermal Immunization of BALB/C Mice with Heat Killed Klebsiella pneumoniae ATCC BAA1706 Leads to the Production of both IgG1 and IgG2a

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