<i>Kocuria kristinae</i> pneumonia and bacteremia

Bernshteyn, Michelle; Kumar, Prashanth Ashok; Joshi, Sumendra

doi:10.1080/08998280.2020.1792749

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…In addition to the damage to the respiratory system of children, severe pneumonia also causes neurological, digestive, circulatory, and other dysfunctions, as well as cerebral edema, mental confusion, irregular respiratory rhythm, and even respiratory arrest (18)(19)(20). Pneumonia is type of pulmonary edema, with congestion caused by a variety of pathogens.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of phentolamine combined with ambroxol aerosol inhalation in the treatment of pediatric severe pneumonia and its effect on serum IL-10 and CRP levels

Li¹,

Wu²,

Zhang³

2022

Transl Pediatr

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Background:The aim of the present study was to determine the therapeutic effect of phentolamine combined with Ambroxol aerosol inhalation on pediatric severe pneumonia and its effect on serum interleukin-10 (IL-10) and C-reactive protein (CRP) levels.Methods: Eighty-five children with severe pneumonia treated in our hospital from November 2019 to November 2020 were selected as the research participants, and were divided into the routine group (n=41) and treatment group (n=44) according to odd and even admission numbers, respectively. Children in the first group received routine treatment, namely symptomatic treatment such as cough relief (e.g., expectorant) and defervescence, while those in the second group received phentolamine combined with Ambroxol aerosol inhalation. Clinical indexes of both groups before and after treatment were analyzed to determine the therapeutic effect of different treatment methods and serum IL-10 and CRP level changes.Results: There was no significant difference in general clinical data between the 2 groups (P>0.05). The duration of cough, fever, abnormal lung sound and lung shadow, and hospitalization time in the treatment group was significantly shorter than those in the routine group (P<0.001). The total clinical effective rate in the treatment group was significantly higher than that in the routine group (P<0.05). Forced vital capacity and peak expiratory flow rate levels were higher in both groups after treatment (P<0.05), and these were higher in the treatment group compared with the routine group after treatment (P<0.05). Serum IL-10 and CRP levels at T1 (2 days after treatment), T2 (5 days after treatment), and T3 (7 days after treatment) in the treatment group were significantly lower than those in the routine group (P<0.001). The total incidence of adverse reactions in the treatment group was significantly lower than that in the routine group (P<0.05).Conclusions: Phentolamine combined with Ambroxol aerosol inhalation can significantly improve the clinical symptoms of children with severe pneumonia, reduce the body's inflammatory response, and improve lung function safely.

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Section: Discussionmentioning

confidence: 99%

Efficacy of phentolamine combined with ambroxol aerosol inhalation in the treatment of pediatric severe pneumonia and its effect on serum IL-10 and CRP levels

Li¹,

Wu²,

Zhang³

2022

Transl Pediatr

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“…This result is in accordance with reported cases by Tewari et al, 24 who recorded an unusual case of a K. kristinae urinary tract infection, Kandi et al 22 and Wojno et al 25 This finding coincides with those of previous studies worldwide like Hassan et al 21 who reported the first case from Egypt with Kocuria kristinae bacteremia and Manzoor et al 19 who discussed a uncommon case of bacteremia caused by K. kristinae in a 46-year-old male patient. Also, Bernshteyn et al 16 presented a unique case report on community-acquired pneumonia and systemic bacteremia caused by K. kristinae in the USA. There is a study of infective endocarditis caused by K. rosea in a 10 year old immune competent female in Brazil by Moreira et al, 12 and Pierron et al 26 have described a case of catheter-related bacteremia with K. rhizophila in an 81 years old diabetic patient.…”

Section: Discussionmentioning

confidence: 99%

“…3 Notably, immunocompromisation was not shown in all case reports. 15,16 Most pediatric cases initiated via K. rosea and K. kristinae were defined only in one child so far, with peritonitis. 10,12 Recently, attention has been drawn to clinical aspects of Kocuria.…”

Section: Introductionmentioning

confidence: 99%

“…10,12 Recently, attention has been drawn to clinical aspects of Kocuria. This include infections such as endocarditis, 12 pneumonia, 16 sepsis (predominantly in immunocompromised patients), 3 and infections related to implanted foreign bodies such as IV lines and catheters. 17 The number of confirmed cases of Kocuria infections in Iraq is very limited, and its clinical pathogenic potency is still dubious.…”

Section: Introductionmentioning

confidence: 99%

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Kocuria Species: Important Emerging Pathogens in Pediatric Patients

Taher¹

2022

J. Pure Appl. Microbiol.

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Kocuria spp., are frequently documented members of the human microbiota and were formerly thought to be opportunistic bacteria, initiating infection only in immunocompromised patients. This study aimed to determine the prevalence of Kocuria species in samples from Iraqi pediatric patients, in addition to their sensitivity pattern. Bacterial identification was performed using a VITEK 2 device, and the Kirby-Bauer disk diffusion method was used to determine antibiotic susceptibility. Of 261 positive cultures, we found Kocuria isolates from 7 cases (2.68%). The mean age of the patients was 5.47 years, ranging from 4 months to 10 years; there were 3 males and 4 females. All patients had either urinary tract disease or symptomatic bacteremia. Vitek-2 identification using a gram-positive (GP) card revealed the presence of Kocuria kristinae in five cases, K. rhizophila in one case, and K. rosea in one case. Susceptibility of the Kocuria species isolates to amikacin, gentamicin and ceftazidime were demonstrated 100% resistance. In conclusion, Kocuria species, which are associated with serious clinical manifestations are an emerging health issue and further attention should be taken for appropriate management of antibiotic treatment as they are intrinsically multi-drug resistant.

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“…Here we present the rare case of pneumonia and bacteremia in an immunocompetent host caused by K. kristinae. 9 Although it is not so common and details of such organisms are not easily available, we expect our report may help to notify the possible pathogenic microorganism in commensal flora and the possibility of drug resistance. K. kristinae has been identified from various sites such as sputum, pus, blood, synovial fluid, bile, throat swab, peritoneal fluid, urine, and urinary catheters.…”

Section: Case Descriptionmentioning

confidence: 91%