<i>Lactiplantibacillus plantarum</i> CCFM8661 alleviates <scp>d</scp>-galactose-induced brain aging in mice by the regulation of the gut microbiota

Chen, Feng; Pan, Jiani; Yu, Leilei; Wang, Shunhe; Zhang, Chengcheng; Zhao, Jianxin; Narbad, Arjan; Zhai, Qixiao; Tian, Fengwei

doi:10.1039/d3fo03377e

Food Funct.

2023

DOI: 10.1039/d3fo03377e

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Lactiplantibacillus plantarum CCFM8661 alleviates d-galactose-induced brain aging in mice by the regulation of the gut microbiota

Feng Chen,

Jiani Pan,

Leilei Yu

et al.

Abstract: Lactiplantibacillus plantarum CCFM8661 alleviates D-galactose induced aging in mice.

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2024

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Cited by 6 publications

References 62 publications

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Tenebrio molitor (Mealworm) protein as a sustainable dietary strategy to improve health span in D-galactose-induced aged mice

Anusha,

Negi

2024

International Journal of Biological Macromolecules

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Tenebrio molitor (Mealworm) protein as a sustainable dietary strategy to improve health span in D-galactose-induced aged mice

Anusha,

Negi

2024

International Journal of Biological Macromolecules

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Neonatal exposure to high d-galactose affects germ cell development in neonatal testes organ culture

Song,

Han,

Lee

et al. 2024

Sci Rep

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Excess exogenous supplementation of d -galactose ( d -gal), a monosaccharide and reducing sugar, generates reactive oxygen species (ROS), leading to cell damage and death. ROS accumulation is critical in aging. Therefore, d -gal-induced aging mouse models are used in aging studies. Herein, we evaluated d -gal’s effect on neonatal testis development using an in vitro organ culture method. Mouse testicular fragments (MTFs) derived from neonatal testes (postnatal day 5) were cultured with 500 mM d -gal for 5 days. d -gal-treated MTFs showed a significantly increased and decreased expression of undifferentiated and differentiated germ cell markers, respectively, with a substantial reduction in meiotic cells. In d -gal-exposed MTFs, expression levels of Sertoli cell markers (Sox9 and Wt1) increased, while those of StAR and 17β-HSD3, whose expressions are abundant in d -Gal treated adult Leydig cells, decreased. Additionally, the enzyme 3 β-HSD1, essential for steroidogenesis in Leydig cells, was significantly reduced in d -gal-exposed MTFs compared to that in controls. d -gal significantly increased the expression of Bad, Bax, and cleaved caspase-3 and -8. Via oxidative stress in MTF. Overall, d -gal negatively regulates germ cell and Leydig cell development in neonatal testes through pro-apoptotic mechanisms and ROS.

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Probiotics as a targeted intervention in anti-ageing: a review

Shi,

Peng,

et al. 2024

Biomarkers

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Lactiplantibacillus plantarum CCFM8661 alleviates d-galactose-induced brain aging in mice by the regulation of the gut microbiota

Abstract: Lactiplantibacillus plantarum CCFM8661 alleviates D-galactose induced aging in mice.

Cited by 6 publications

References 62 publications

Tenebrio molitor (Mealworm) protein as a sustainable dietary strategy to improve health span in D-galactose-induced aged mice

Tenebrio molitor (Mealworm) protein as a sustainable dietary strategy to improve health span in D-galactose-induced aged mice

Neonatal exposure to high d-galactose affects germ cell development in neonatal testes organ culture

Probiotics as a targeted intervention in anti-ageing: a review

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