<i>Lactobacillus fermentum</i> JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Zhang, D I; Li, Chuang; Shi, Ruirui; Zhao, Fang; Yang, Zhengyou

doi:10.33073/pjm-2020-024

Cited by 20 publications

(14 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All CFS and the control MRS showed similar relative concentrations of polyphenolic compounds ( P < 0.05). Other articles, such as those by Zhang et al 38 . and Sirin et al ., 39 reported similar results for DPPH radical‐scavenging activity, around 30% higher than the control.…”

Section: Resultssupporting

confidence: 62%

“…All CFS and the control MRS showed similar relative concentrations of polyphenolic compounds (P < 0.05). Other articles, such as those by Zhang et al 38 and Sirin et al, 39 reported similar results for DPPH radical-scavenging activity, around 30% higher than the control. Nevertheless, total polyphenol concentrations seemed to be lower than the average compared to results reached by other LAB.…”

Section: Identification Of Antifungal Compoundssupporting

confidence: 59%

See 1 more Smart Citation

Potential application of lactic acid bacteria in the biopreservation of red grape from mycotoxigenic fungi

et al. 2021

View full text Add to dashboard Cite

BACKGROUND: Filamentous fungi are the main contamination agent in the viticultural sector. Use of synthetic fungicides is the regular answer to these contaminations. Nevertheless, because of several problems associated with the use of synthetic compounds, the industry demands new and safer methods. In the present work, the biopreservation potential of four lactic acid bacteria (LAB) strains was studied against the principal grape contaminant fungi.RESULTS: Agar diffusion test evidenced that all four culture-free supernatant (CFS) had antifungal properties against all tested fungi. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) test values evidenced that media fermented by the Lactobacillus plantarum E3 and Lactobacillus plantarum E4 strains showed the highest antifungal activity, resulting in an MFC from 6.3 to 100 g L −1 . Analysis of CFS evidenced the presence of different antifungal compounds, such as lactic acid, phenyllactic acid and pyrazines. In tests on red grapes, an average reduction of 1.32 log 10 of the spores per gram of fruit was achieved by all CFS in grapes inoculated with Aspergillus ochraceus and by 0.94 log 10 for L. plantarum E3 CFS against Botrytis cinerea. CONCLUSION:The antifungal activity of the fermented CFS by L. plantarum E3 reduced the growth of B. cinerea and A. ochraceus in grapes, which are the main contaminant and main producer of ochratoxin A in these crops, respectively. Therefore, based on the results obtained in this work, use of the strain L. plantarum E3 could be an interesting option for the biopreservation of grapes.

show abstract

Section: Resultssupporting

confidence: 62%

Section: Identification Of Antifungal Compoundssupporting

confidence: 59%

Potential application of lactic acid bacteria in the biopreservation of red grape from mycotoxigenic fungi

et al. 2021

View full text Add to dashboard Cite

show abstract

“…CAT can promote the decomposition of H 2 O 2 into molecular oxygen and water [ 26 ], whereas GSH-Px catalyzes the reduction in H 2 O 2 or organic hydroperoxides to water or alcohols, respectively [ 27 ]. Malondialdehyde is the by-product of lipid peroxidation, and its concentration is widely used as a biomarker of the lipid peroxidation level [ 28 ]. The finding revealed that PPF could enhance SOD, GSH-Px, CAT activity, and reduce MDA content in serum and liver to resist ROS damage in this study, which is in agreement with the antioxidant function of flavonoids in other studies.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice

2021

View full text Add to dashboard Cite

This study was aimed to investigate the antioxidant effect of Paeonia lactiflora Pall. petal flavonoids extract (PPF) on d-galactose (d-gal)-induced ICR mice. In this study, sixty male ICR mice were randomly divided into six groups during an 8 weeks experimental period, including normal control (NC) group, d-gal group, epigallocatechin gallate (EGCG) group, low, medium, and high dose PPF groups (10, 20 and 40 mg/kg/day). The results showed that intragastric administration with PPF significantly reverses the atrophy of the visceral organs of oxidative damage mice in a dose-dependent relationship. PPF indicated the antioxidant capacity to decrease the malondialdehyde (MDA) level and improve the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px). In addition, PPF treatment reversed gut microbiota dysbiosis by increasing the relative abundance of Lactobacillaceae. Spearman correlation analysis showed that the body’s oxidative stress markers were directly related to changes in gut microbiota. These findings reveal firstly that PPF could alleviate d-Gal-induced oxidative stress and modulate gut microbiota balance.

show abstract

“…As an alternative mechanism, it might scavenge free radicals and work synergistically with CAT, GSH-Px, and SOD to lower oxidative stress. In male Kunming mice, it was observed that L. fermentum JX306, obtained from Chinese traditional fermented vegetable samples, significantly reduced MDA levels and enhanced the activity of GSH-Px, and total antioxygenic capacity (TOC) in the liver and kidney serum (Zhang et al 2020 ). The strain showed a remarkable upregulation of the transcriptional level of antioxidant-related enzyme genes, such as thioredoxin reductase (TR3), glutathione peroxidase (Gpx1), peroxiredoxin1 (Prdx1), and glutathione reductase (Gsr) encoding genes in the liver (Table 1 ).…”

Section: Lactobacillus Sp Role In Ameliorating D-galactose-i...mentioning

confidence: 99%

Antioxidative potential of Lactobacillus sp. in ameliorating D-galactose-induced aging

Kumar

Bhardwaj

Valko

et al. 2022

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Aging is a progressive, unalterable physiological degradation process of living organisms, which leads to deterioration of biological function and eventually to senescence. The most prevalent factor responsible for aging is the accumulation of damages resulting from oxidative stress and dysbiosis. D-galactose-induced aging has become a hot topic, and extensive research is being conducted in this area. Published literature has reported that the continuous administration of D-galactose leads to the deterioration of motor and cognitive skills, resembling symptoms of aging. Hence, this procedure is employed as a model for accelerated aging. This review aims to emphasize the effect of D-galactose on various bodily organs and underline the role of the Lactobacillus sp. in the aging process, along with its anti-oxidative potential. A critical consideration to the literature describing animal models that have used the Lactobacillus sp. in amending D-galactose-induced aging is also given. Key points • D-Galactose induces the aging process via decreasing the respiratory chain enzyme activity as well as ATP synthesis, mitochondrial dysfunction, and increased ROS production. • D-Galactose induced aging primarily affects the brain, heart, lung, liver, kidney, and skin. • The anti-oxidative potential of Lactobacillus sp. in improving D-galactose-induced aging in animal models via direct feeding and feeding of Lactobacillus-fermented food.

show abstract

Lactobacillus fermentum JX306 Restrain D-galactose-induced Oxidative Stress of Mice through its Antioxidant Activity

Cited by 20 publications

References 44 publications

Potential application of lactic acid bacteria in the biopreservation of red grape from mycotoxigenic fungi

Potential application of lactic acid bacteria in the biopreservation of red grape from mycotoxigenic fungi

Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice

Antioxidative potential of Lactobacillus sp. in ameliorating D-galactose-induced aging

Contact Info

Product

Resources

About