<i>Lactobacillus gasseri</i>CKCC1913 mediated modulation of the gut–liver axis alleviated insulin resistance and liver damage induced by type 2 diabetes

Jiang, Shuaiming; Liu, Aijie; Ma, Wenyao; Liu, Xinlei; Luo, Pengfei; Zhan, Meng; Zhou, Xiaoli; Chen, Lihao; Zhang, Jiachao

doi:10.1039/d3fo01701j

Cited by 14 publications

(3 citation statements)

References 75 publications

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“…However, the significant negative correlation (P < 0.05) between s_Parabacteroides_merdae and body fat and systemic pressure makes it reasonable to speculate that the enrichment of s_Parabacteroides_merdae can increase the production of short chain fatty acids, thereby reducing the risk of diabetes and the damage to the cardiovascular system. Although blueberry co-exercise did not yield significant results in increasing the abundance of these bacteria in the participants, its strong correlation with systolic blood pressure in hypertensive individuals is a promising sign for moderate improvements in the body, such as the regulation of immune cells and a decrease in inflammation 31,32 .…”

Section: Discussionmentioning

confidence: 87%

A prospective microbiome analysis of the impact of physical exercise and blueberry supplementation on the gut microbiome of obesity-induced hypertensive in college students

Cheng,

Li,

et al. 2024

Food Science and Human Wellness

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Section: Discussionmentioning

confidence: 87%

A prospective microbiome analysis of the impact of physical exercise and blueberry supplementation on the gut microbiome of obesity-induced hypertensive in college students

Cheng,

Li,

et al. 2024

Food Science and Human Wellness

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“…As our data indicated, gut microbiota α-diversity was higher in LGG sows when compared to CON sows, consistent with research showing that LGG enhanced α-diversity in an insulin resistance mouse model [ 41 ]. Previous reports also showed that individuals with insulin resistance had lower Lactobacillus abundance [ 42 , 43 ], which could be increased by LGG [ 44 ]. Consistent with these observations, we identified higher Lactobacillus abundance in LGG sows.…”

Section: Discussionmentioning

confidence: 99%

Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

Gao,

Li,

et al. 2024

J Animal Sci Biotechnol

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Background Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake and milk production, which can lead to higher mortality rates in newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known to improve insulin resistance. However, whether supplementing LGG can improve insulin sensitivity in sows and enhance lactation performance, particularly the early survival of offspring remains unclear. Hence, we explored the effects and mechanisms of supplementing LGG during late gestation and lactation on sow insulin sensitivity, lactation performance, and offspring survival. In total, 20 sows were randomly allocated to an LGG (n = 10) and control group (n = 10). Results In sows, LGG supplementation significantly improved insulin sensitivity during late gestation and lactation, increased feed intake, milk production and colostrum lactose levels in early lactation, and enhanced newborn piglet survival. Moreover, LGG treatment significantly reshaped the gut microbiota in sows, notably increasing microbiota diversity and enriching the relative abundance of insulin sensitivity-associated probiotics such as Lactobacillus, Bifidobacterium, and Bacteroides. Serum metabolite and amino acid profiling in late-gestation sows also revealed decreased branched-chain amino acid and kynurenine serum levels following LGG supplementation. Further analyses highlighted a correlation between mitigated insulin resistance in late pregnancy and lactation by LGG and gut microbiota reshaping and changes in serum amino acid metabolism. Furthermore, maternal LGG enhanced immunity in newborn piglets, reduced inflammation, and facilitated the establishment of a gut microbiota. Conclusions We provide the first evidence that LGG mitigates insulin resistance in sows and enhances offspring survival by modulating the gut microbiota and amino acid metabolism.

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“…Treatment of Lactobacillus gasseri strain CKCC1913 in diabetic mice reduced insulin resistance, fasting blood glucose levels, serum levels of pro-inflammatory cytokines (eg, TNF-α and IL-6), and hepatic oxidative stress-induced damage by increasing SOD activity and decreasing malondialdehyde levels. This therapy increased the abundance of beneficial bacteria such as Parabacteroides merdae and the production of short-chain fatty acids (SCFAs) to reduce liver oxidative stress and inflammation [ 28 ] . In vitro treatment of Lactobacillus sakei MJM60958 inhibited oleic acid and cholesterol-induced hepatocyte lipid accumulation.…”

Section: The Role Of Gut Microbiota In Liver Inflammationmentioning

confidence: 99%

Gut microbiota and metabolite interface-mediated hepatic inflammation

Yang,

Massad,

Kimchi

et al. 2024

Immunometabolism

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Immunologic and metabolic signals regulated by gut microbiota and relevant metabolites mediate bidirectional interaction between the gut and liver. Gut microbiota dysbiosis, due to diet, lifestyle, bile acids, and genetic and environmental factors, can advance the progression of chronic liver disease. Commensal gut bacteria have both pro- and anti-inflammatory effects depending on their species and relative abundance in the intestine. Components and metabolites derived from gut microbiota–diet interaction can regulate hepatic innate and adaptive immune cells, as well as liver parenchymal cells, significantly impacting liver inflammation. In this mini review, recent findings of specific bacterial species and metabolites with functions in regulating liver inflammation are first reviewed. In addition, socioeconomic and environmental factors, hormones, and genetics that shape the profile of gut microbiota and microbial metabolites and components with the function of priming or dampening liver inflammation are discussed. Finally, current clinical trials evaluating the factors that manipulate gut microbiota to treat liver inflammation and chronic liver disease are reviewed. Overall, the discussion of microbial and metabolic mediators contributing to liver inflammation will help direct our future studies on liver disease.

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Lactobacillus gasseriCKCC1913 mediated modulation of the gut–liver axis alleviated insulin resistance and liver damage induced by type 2 diabetes

Abstract: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by dysregulation of lipid metabolism, insulin resistance, and gut microbiota disorder. Compared to drug interventions, probiotic interventions may have...

Cited by 14 publications

References 75 publications

A prospective microbiome analysis of the impact of physical exercise and blueberry supplementation on the gut microbiome of obesity-induced hypertensive in college students

A prospective microbiome analysis of the impact of physical exercise and blueberry supplementation on the gut microbiome of obesity-induced hypertensive in college students

Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

Gut microbiota and metabolite interface-mediated hepatic inflammation

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