2020
DOI: 10.1089/jmf.2019.4604
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Lactobacillus HY2782 and Bifidobacterium HY8002 Decrease Airway Hyperresponsiveness Induced by Chronic PM2.5 Inhalation in Mice

Abstract: Epidemiological studies have shown that exposure to particulate matter (PM) is associated with adverse health effects. Inhalation of fine particulate matter (PM2.5) is associated with elevated pulmonary diseases. However, the molecular mechanism underlying the initiation of lung inflammation following inhalation is unclear. In this study, we investigated the beneficial effects of two probiotics, Lactobacillus casei HY2782 and Bifidobacterium lactis HY8002, against PM-induced pulmonary inflammation. Model mice … Show more

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Cited by 18 publications
(13 citation statements)
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“…L. casei HY2782 is used as a starter strain for Korean Yakult fermented milk products. Previous studies have shown that L. casei HY2782 has various functions such as increasing the expression of interleukin 12 in dendritic cells [18] and preventing the toxic effect induced by particulate matter [19,20]. Previous studies found that growth and metabolism mostly cease after 24 h of incubation.…”
Section: Introductionmentioning
confidence: 99%
“…L. casei HY2782 is used as a starter strain for Korean Yakult fermented milk products. Previous studies have shown that L. casei HY2782 has various functions such as increasing the expression of interleukin 12 in dendritic cells [18] and preventing the toxic effect induced by particulate matter [19,20]. Previous studies found that growth and metabolism mostly cease after 24 h of incubation.…”
Section: Introductionmentioning
confidence: 99%
“…Lin et al (2020), showed that Lactobacillus paracasei decreased the type 2 allergic response induced by OVA and PM, by decreasing the IgE levels, cytokines IL-4, IL-5, IL-13, and histamine [127]. This was confirmed by Nam et al (2020), who also showed that probiotics can protect against PM-induced airway inflammation [128]. In contrast, Yang et al (2021) demonstrated that the commensal microbiome can have a negative effect on the airways by promoting PM-induced acute neutrophilia in the lung via the IL-17 producing γδ T cells [114].…”
Section: Particulate Mattermentioning
confidence: 91%
“…The AHR mouse model was generated according to the method described by Nam et al (2020). Briefly, male C57BL/6 mice were randomly divided into five groups of 8 mice each: (1) control group (Con), (2) PM2.5-induced group (PM), (3) L. casei HY2782-administered group (HY2782), (4) combination of L. casei HY2782 and PRE- and a combination of HY2782 (1×10 8 CFU/kg/d) and PRE (10 mg/kg/d).…”
Section: Administration To Animalsmentioning
confidence: 99%
“…These results suggest that the HY2782 complex effectively decreases Th2 and Th17 inflammation induced in PM2.5-exposed mice. Previous studies have shown that L. casei HY2782 has various health benefits, such as preventing intestinal disease by tight-junction proteins (Jung et al, 2021), increasing IL-12 expression in dendritic cells (Park et al, 2020), and preventing toxic effects of PM (Kim et al, 2020;Nam et al, 2020).…”
Section: Et Al 2019) the Heterogeneity Of Memory Cd4mentioning
confidence: 99%
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