Lactobacillus johnsonii 6084 alleviated sepsis‐induced organ injury by modulating gut microbiota

Abstract

Sepsis is a public cause of death in intensive care unit patients. Probiotics were widely used to increase the survival rate of sepsis by a series of clinical research. The purpose of this research was to investigate the therapeutic effects of Lactobacillus johnsonii 6084 in septic mice. Sepsis mouse model was induced by LPS treatment. The influence of L. johnsonii 6084 on the protection of organ injury induced by sepsis was explored. Moreover, the composition of gut microbiota was studied to clarify the mechanism of L. johnsonii 6084 therapeutic effect on sepsis. L. johnsonii 6084 treatment could conspicuously decrease the mortality and organ injury of sepsis. The reduction of gut microbial diversity and richness in septic mice were moderated by the administration of 6084. The abundance of Bacteroidetes and Proteobacteria were change by LPS treatment while restored by L. johnsonii 6084. To conclude, probiotic 6084 may has optimistic result on reducing mortality of sepsis through rebalancing gut microbiota.

Lactococcus lactis HkyuLL 10 suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase

“…Previous studies reported that the administration of these Lactobacilli could facilitate the reconstruction of a balanced microbiota with improved intestinal integrity in mice. [17][18][19] Introducing a probiotic mixture containing six Bifidobacteria and Lactobacillus strains to postsurgery patients also lead to a significant reduction in pro-inflammatory cytokines and restoration in the intestinal microenvironment. 20 Hence, these findings indicated that HkyuLL 10 suppresses CRC tumourigenesis, at least in part, through modulating and renovating the gut microbiota back to healthy and balanced conditions.…”

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets

“…Lactobacillus johnsonii and Weissella jogaeotgali are two important probiotics that produce acid, inhibit bacteria and have good adhesion to intestinal epithelial cells. It performs well in improving the structure of the gut microbiota and enhancing the integrity of the intestinal barrier ( Teixeira et al., 2021 ; Bai et al., 2022 ; Han et al., 2022 ; Fanelli et al., 2023 ).…”

Investigation of Gut Microbiota Disorders in Sepsis and Sepsis Complicated with Acute Gastrointestinal Injury Based on 16S rRNA Genes Illumina Sequencing

“…30,32 The Bacteroidota, also known as Bacteroidetes, is an anaerobic bacterium that plays a role in immunity and 33 It is usually associated with gut inflammation, and its abundance is also different before and after the treatment of sepsis. 34,35 In the Circos diagram, Firmicutes and Bacteroidota is a dominant species at the phylum level. Moreover, the abundance of Firmicutes in the sepsis group was reduced compared to the control group, which is consistent with previous studies.…”