<i>Lactobacillus paracasei</i> L9 improves colitis by expanding butyrate-producing bacteria that inhibit the IL-6/STAT3 signaling pathway

Deng, Min; Wu, Xi; Duan, Xiaoyue; Xu, Jiuzhi; Yang, Xu; Sheng, Xiaole; Lou, Pengbo; Shao, Chunlei; Lv, Cong; Yu, Zhengquan

doi:10.1039/d1fo02077c

Cited by 21 publications

(14 citation statements)

References 64 publications

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“…In contrast to the study above, results of a study showed that Lacticaseibacillus paracasei L9 activated the TLR2/MAPK signaling pathway, promoted the differentiation of DCs to CD103+DCs and CX3CR1+DCs, enhanced the secretion of regulatory cytokines, increased the number of Foxp3+Treg and IL-10+Treg cells, corrected the Th1/Th2 imbalance in the allergic organism, and alleviated the Th1/Th2. The effect of the treatment was to alleviate the symptoms of cow’s milk protein allergy in mice [ 62 ].…”

Section: Probiotics Regulate Immunity Through Intestinal Floramentioning

confidence: 99%

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Huang

Liang

et al. 2023

Molecules

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Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

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Section: Probiotics Regulate Immunity Through Intestinal Floramentioning

confidence: 99%

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Huang

Liang

et al. 2023

Molecules

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“…Probiotics are vital components of intestinal microbiota and play an essential role in attenuating inflammatory bowel diseases. Several studies reported that some probiotics could alleviate dextran sulfate sodium (DSS)-induced UC in mice through modulating gut microbiota, such as Lactobacillus rhamnosus [7] and Lactobacillus paracasei [23]. Lacticaseibacillus rhamnosus LS8 (LR), previously isolated from homemade fermented milk, was a potential intestinal microbiota-modulating strain as it can secrete a novel small molecule antibacterial substance-cyclic opine: cycloalanopine (4,6-dimethyl-1,2,5-triazepane-3,7-dione, C6H11N3O2, 157.09 Da, ) and inhibit the growth of food-borne and multidrug-resistant pathogens [24].…”

Section: Introductionmentioning

confidence: 99%

The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study

Wang¹,

Wang²,

Dong³

et al. 2024

Food Science and Human Wellness

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Intestinal microbiota imbalance may worsen the progression of ulcerative colitis (UC). Lacticaseibacillus rhamnosus LS8 (LR) has the potential ability to regulate microbiota through producing a novel antibacterial substance, cyclic opine: cycloalanopine. This study aimed to investigate whether LR could ameliorate dextran sulfate sodium-induced UC in mice via modulating intestinal microbiota using fecal microbiota transplantation (FMT) experiment. The results showed that both LR and FMT attenuated UC as evidenced by (1) alleviating disease activity index and colonic pathology; (2) up-regulating MUCs and tight junction proteins; (3) increasing oxidative mediators and decreasing antioxidant mediators; (4) down-regulating proinflammatory cytokines and chemokines. These results were mainly attributable to the microbiota-regulating effect of LR, including increasing beneficial bacteria (like Akkermansia) and its related SCFAs, while decreasing harmful bacteria (like Proteobacteria) and its related LPS, thereby suppressing the hyperactivation of TLR4/NF-κB. Consequently, LR can alleviate UC and is a potential dietary supplement to attenuate UC.

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“…16 It was found that L. paracasei L9 ameliorated UC in mice by increasing butyrateproducing bacteria in the intestine, thereby inhibiting the IL-6/ STAT3 signaling pathway. 17 Likewise, another study showed that B. adolescentis ATCC15703 could alleviate experimental UC in mice by modulating the Treg/Th2 response and gut microbiota. 18 Notably, many Lactobacillus and Bif idobacterium strains alleviate UC by acting through their metabolites or structural components, such as exopolysaccharides (EPS), 19 tryptophan metabolites, 20 conjugated linoleic acid, 21 and surface layer proteins (SLP).…”

Section: ■ Introductionmentioning

confidence: 99%

Exopolysaccharides Produced by Bifidobacterium longum subsp. longum YS108R Ameliorates DSS-Induced Ulcerative Colitis in Mice by Improving the Gut Barrier and Regulating the Gut Microbiota

Li,

Stanton

et al. 2024

J. Agric. Food Chem.

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Ulcerative colitis (UC) is a major disease that has endangered human health. Our previous study demonstrated that Bifidobacterium longum subsp. longum YS108R, a ropy exopolysaccharide (EPS)-producing bacterium, could alleviate UC in mice, but it is unclear whether EPS is the key substance responsible for its action. In this study, we proposed to investigate the remitting effect of EPS from B. longum subsp. longum YS108R on UC in a DSS-induced UC mouse model. Water extraction and alcohol precipitation were applied to extract EPS from the supernatant of B. longum subsp. longum YS108R culture. Then the animal trial was performed, and the results indicated that YS108R EPS ameliorated colonic pathological damage and the intestinal barrier. YS108R EPS suppressed inflammation via NF-κB signaling pathway inhibition and attenuated oxidative stress via the Nrf2 signaling pathway activation. Remarkably, YS108R EPS regulated gut microbiota, as evidenced by an increase in short-chain fatty acid (SCFA)-producing bacteria and a decline in Gram-negative bacteria, resulting in an increase of propionate and butyrate and a reduction of lipopolysaccharide (LPS). Collectively, YS108R EPS manipulated the intestinal microbiota and its metabolites, which further improved the intestinal barrier and inhibited inflammation and oxidative stress, thereby alleviating UC.

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Lactobacillus paracasei L9 improves colitis by expanding butyrate-producing bacteria that inhibit the IL-6/STAT3 signaling pathway

Abstract: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation that is currently incurable. Increasing evidences indicate that supplementation with probiotics could improve the symptoms of IBD. It is scientifically significant...

Cited by 21 publications

References 64 publications

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

The role of a novel antibacterial substance,cyclic opine-producing Lacticaseibacillus rhamnosus LS8 in ameliorating ulcerative colitis:a fecal microbiota transplantation study

Exopolysaccharides Produced by Bifidobacterium longum subsp. longum YS108R Ameliorates DSS-Induced Ulcerative Colitis in Mice by Improving the Gut Barrier and Regulating the Gut Microbiota

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