<i>Lactobacillus plantarum</i><scp>CECT</scp> 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels

Bosch, Montserrat; Fuentes, Mari Carmen; Audivert, Sergi; Bonachera, M. A.; Peiró, Sara; Cuñé, Jordi

doi:10.1002/jsfa.6467

Cited by 48 publications

(35 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is evidence of the potential benefit of some strains and species of probiotics for a variety of indications 38 most recently that proposed for species of L. plantarum as candidates to reduce cholesterol levels. 64 A summary of a selection of probiotic species that have been reported efficacious in several specific health indications is presented in Table 2. The typical doses in this select group of studies varied between 10 10 and 10 11 CFU per dose administered.…”

Section: Discussionmentioning

confidence: 99%

Probiotics, D–Lactic acidosis, oxidative stress and strain specificity

et al. 2017

View full text Add to dashboard Cite

The existence of an implicit living microscopic world, composed primarily of bacteria, has been known for centuries. The exact mechanisms that govern the contribution of bacteria to human health and disease have only recently become the subject of intense research efforts. Within this very evident shift in paradigms, the rational design of probiotic formulations has led to the creation of an industry that seeks to progress the engineering of probiotic bacteria that produce metabolites that may enhance human host health and prevent disease. The promotion of probiotics is often made in the absence of quality scientific and clinically plausible data. The latest incursions into the probiotic market of claims have posited the amelioration of oxidative stress via potent antioxidant attributes or limiting the administration of probiotics to those species that do not produce D-Lactic acid (i.e., claims that D-Lactic acid acidosis is linked to chronic health conditions) or are strain-specific (shaping an industry point of difference) for appraising a therapeutic effect. Evidence-based research should guide clinical practice, as there is no place in science and medicine that supports unsubstantiated claims. Extravagant industry based notions continue to fuel the imprimatur of distrust and skepticism that is leveled by scientists and clinicians at an industry that is already rife with scientific and medical distrust and questionable views on probiotics. Ignoring scientifically discordant data, when sorting through research innovations and false leads relevant to the actions of probiotics, drives researcher discomfit and keeps the bar low, impeding the progress of knowledge. Biologically plausible posits are obligatory in any research effort; companies formulating probiotics often exhibit a lack of analytical understanding that then fuels questionable investigations failing to build on research capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Probiotics, D–Lactic acidosis, oxidative stress and strain specificity

et al. 2017

View full text Add to dashboard Cite

show abstract

“…LAB are reported to have intrinsic and acquired resistances to many classes of antibiotics, only some of which are known to be transferable (Nawaz et al, 2011;Zhang et al, 2011). To resolve the discrepancies in MIC between the present study and a previous report (Bosch et al, 2014), a more comprehensive genomic mining strategy was utilized. While the EFSA microbiological cut-off value was not exceeded for chloramphenicol in any of the strains, a conserved cat gene was annotated and no other known antibiotic resistance genes were identified.…”

Section: Antimicrobial Resistancementioning

confidence: 78%

“…The three AB-LIFE ® strains, L. plantarum CECT 7527, 7528, and 7529, have been reported to exhibit bile salt hydrolase (BSH) activity and cholesterol lowering ability in vitro (Bosch et al, 2014). BSHs are believed to promote bacterial colonization of the lower small intestine, though the activity varies depending on the composition of the individual microbiota, and may vary between bacterial genera (Ridlon et al, 2006).…”

Section: Bile Acids and Neutral Sterolsmentioning

confidence: 99%

Safety evaluation of AB-LIFE® (Lactobacillus plantarum CECT 7527, 7528 and 7529): Antibiotic resistance and 90-day repeated-dose study in rats

Mukerji

Roper

Stahl

et al. 2016

Food and Chemical Toxicology

View full text Add to dashboard Cite

“…Hiperkolesterolemi özellikle laktobasillerin sayıca artması durumunda şiddetlenmektedir ve kolesterol KVH ile direk ilişkilidir (44). Otizm hastalarında genetik ve çevresel faktörlerin yanında diyare, dispepsi gibi gastrointestinal semptomlarda yer alır (45).…”

Section: Mikrobiyotanın Lokal Inflamasyon Ve Immün Düzenleyici Rolüunclassified

Microbiota ve Cancer

Salman¹,

Varol²,

Yıldız³

et al. 2015

Acta Oncol Tur.

View full text Add to dashboard Cite

ÖZETMikrobiyota vücudumuzu paylaştığımız tüm mikroorganizmaların tanımıdır.Mikrobiyota bir ekosistem olup insan sağlığında besinlerin ve K vitaminin sağlanması, sindirimde rol ynar. Mikrobiyota immün fonksiyonu biyolojik aktif metabolitler sayesinde etkiler ve mikrobiyotanın değişimi (disbiyozis) pek çok hastalığın gelişiminde yer alır. Son yapılan çalışmalar mikrobiyotanın immün kaçış mekanizması sayesinde karsinojenezisin önemli bir parçası olduğunu ve kanser tedavisinde de etkili olabileceğini göstermiştir. Anahtar kelimeler: Mikrobiyota, kanserABSTRACT Microbiota is all microorganisms that share our body and microbiota ecosystem plays an important role in human health such as spplying nutrients, K vitamin, digestion, Microbiota affects many immun functions by biological molecules and change of the microbiota (disbiosis) has a critical roles development of multple diseases. Recently it has been reported that microbiota is an important part of carcinogenesis cause by immun evasion and has effect on the treatment of cancer.

show abstract

Lactobacillus plantarumCECT 7527, 7528 and 7529: probiotic candidates to reduce cholesterol levels

Abstract: Combined, these characteristics suggest that these strains could be excellent candidates for reducing high blood cholesterol levels.

Cited by 48 publications

References 20 publications

Probiotics, D–Lactic acidosis, oxidative stress and strain specificity

Probiotics, D–Lactic acidosis, oxidative stress and strain specificity

Safety evaluation of AB-LIFE® (Lactobacillus plantarum CECT 7527, 7528 and 7529): Antibiotic resistance and 90-day repeated-dose study in rats

Microbiota ve Cancer

Contact Info

Product

Resources

About