<i>Lactobacillus reuteri</i> therapy to reduce side‐effects during anti‐<i>Helicobacter pylori</i> treatment in children: a randomized placebo controlled trial

Lionetti, Elena; Miniello, Vito Leonardo; Castellaneta, Stefania; Magistà, Anna Maria; Canio, A. De; Maurogiovanni, Giovanni; Ierardi, Enzo; Cavallo, Luciano; Francavilla, Ruggiero

doi:10.1111/j.1365-2036.2006.03145.x

Cited by 149 publications

(94 citation statements)

References 38 publications

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“…Of all trials, sequence generation (method of randomization) was clear and appropriate. Concealment was unclear in 7 studies (12,13,16,(23)(24)(25)(26), which was performed by using appropriately sealed boxes in 2 studies (14,27). Knowledge of the assigned intervention may impact on behavioral outcomes (such as number of clinic visits) but not on physiological outcomes.…”

Section: Risk Of Bias Assessment Of Included Studiesmentioning

confidence: 99%

Lactobacillus -containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis

Zheng¹,

Lin²,

Mei³

2013

Rev. esp. enferm. dig.

103

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Background: Helicobacter pylori infection is recognized as a major contributory factor to many diseases, but recommended eradication therapies demonstrated unsatisfactory eradication rates. Currently, some studies suggested that lactobacillus species have an inhibitory action on Helicobacter pylori both in vitro and in vivo.Objective: this meta-analysis broadly examined the efficacy of eradication regimens supplemented with lactobacillus-containing probiotic on eradication rates and side effects.Methods: eligible articles were identified by comprehensive searches. Statistical analysis was performed with Review Manager 5.2. Outcomes were finally evaluated according to GRADE system.Results: nine randomized controlled trials of high-quality met eligible criteria. Risk ratio of eradication was available for 1,163 patients. Lactobacillus-containing probiotics significantly increased the eradication rate compared with the control group based upon intention-to-treat analysis [RR = 1.14; 95 %CI (1.06-1.22); number needed to treat (NNT) = 10] by the fixed effect model without significant publication bias, but no significant reduction associated with overall side effects was observed [RR = 0.88;]. In the subgroup analysis, eradication rates raised significantly by 17 % in lactobacillus administrated alone group [RR = 1.25; 95 %CI (1.13-1.37); NNT = 6]. In multistrain probiotics group, eradication rates enhanced only 2.8 % [RR = 1.04; 95 %CI (0.94-1.14)]. It also showed that lactobacillus-containing probiotics improved the eradication rates, respectively, both in adults [RR = 1.12; Conclusions: Lactobacillus-containing probiotic as an adjunct is effective to eradication therapy, while side effects caused by eradication treatment may not decrease. Furthermore, lactobacillus administrated alone will distinctly benefit eradication therapy.

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Section: Risk Of Bias Assessment Of Included Studiesmentioning

confidence: 99%

Lactobacillus -containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis

Zheng¹,

Lin²,

Mei³

2013

Rev. esp. enferm. dig.

103

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“…In the present study, the positive rate of bacteria in the treatment group was significantly lower than that in the control group, revealing S. boulardii can inhibit bacterial overgrowth and regulate flora disturbance to maintain the balance of micro-ecological system in the stomach. Bacterial resistance and patient compliance are the two major factors that contributed to the eradication rate of HP (Lionetti et al, 2006) and the rate decreases with tolerance increase by the heavy use of antibiotics. In recent years, substantial evidence shows that probiotics may have beneficial effects in eradicating HP (Yang, 2006), reducing side-effects of antibiotics, and improving patient compliance.…”

Section: Discussionmentioning

confidence: 99%

Intervention study on Saccharomyces boulardii with proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori related peptic ulcer

Chu¹

2012

Afr. J. Pharm. Pharmacol.

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The study was undertaken to investigate the efficacy and safety of Saccharomyces boulardii combined with proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori related peptic ulcer. One hundred patients with H. pylori infection were randomized in two groups: intervention and control group. Both groups were treated with the standard triple eradication therapy (omeprazole, amoxicillin and clarithromycin). The effective rate of the improvement in the treatment group was 96.0%, and was significantly higher than the control group (62.0%) (x 2 = 6.899, P < 0.01). The pH of the two groups was also elevated after the treatment (P < 0.05, P < 0.05); the positive culture rate of bacteria increased obviously and there was significant difference between the two groups (P < 0.05). The eradication rate of H. pylori in the treatment group was 84.4% and was significantly higher than the control group (64.4%) (x 2 = 5.848, P < 0.01). In addition, the rate of recurrence in the treatment group was 10.0%, while in the control group it was 26.0% after treated for one year (x 2 = 11.584, P < 0.01). There was significant difference in the rate of adverse events between the two groups (15.6 and 57.8% of the treatment group and control group, respectively; x 2 = 18.936, P < 0.01). Therefore, S. boulardii with PPI-based triple therapy for peptic ulcer is effective with a low recurrence rate and can reduce the incidence of adverse events.

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“…A short term daily ingestion of L. reuteri delivered by drinking straw or tablets reduced the levels of salivary Streptococci in young adults (Caglar et al 2006). The L. reuteri supplementation during and after Helicobacter pylori eradication therapy significantly reduced the frequency and intensity of antibiotic associated side effects (Lionetti et al 2006). The administration of L. reuteri significantly decreased UBT (Urea Breath Test) values in H. pylori positive subjects, demonstrating that L. reuteri suppressed H. pylori density (Imase et al 2005).…”

Section: Prevention Of Infectious Diseasesmentioning

confidence: 99%

Mechanism of action of probiotics

Hemaiswarya

Raja

Ravikumar

et al. 2013

Braz. arch. biol. technol.

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Lactobacillus reuteri therapy to reduce side‐effects during anti‐Helicobacter pylori treatment in children: a randomized placebo controlled trial

Abstract: SUMMARY BackgroundHelicobacter pylori eradication fails in about 25-30% of children, particularly because of the occurrence of resistance to antibiotics and side-effects.

Cited by 149 publications

References 38 publications

Lactobacillus -containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis

Lactobacillus -containing probiotic supplementation increases Helicobacter pylori eradication rate: evidence from a meta-analysis

Intervention study on Saccharomyces boulardii with proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori related peptic ulcer

Mechanism of action of probiotics

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