<i>Lagerstroemia speciosa</i>
            (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats

Singh, Thakur Rohit; Ezhilarasan, Devaraj

doi:10.1080/01480545.2021.1945079

Cited by 5 publications

(5 citation statements)

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“…The hepatoprotective effect of those herbal extracts was mainly attributed to the hepatocellular membrane stabilizing properties due to the presence of several phytochemicals. These phytochemicals are implicated in the restoration of membrane stability and recovery from hepatic damage [11]. In our previous studies [10,13], we have reported the presence of berberine, gallic acid, and ellagic acid in EBLE.…”

Section: Discussionmentioning

confidence: 86%

“…In light of these reports, it is likely that INH-induced oxidative damage may result in the acceleration of LPO and cause injury to the hepatocyte membrane, and this could be the most probable cause for the INH-induced elevation of marker enzymes of hepatotoxicity in serum. Many plant extracts and their derived phytochemicals have been studied to evaluate their efficacy versus anti-TB drug-induced hepatic damage in different animal models [11].…”

Section: Discussionmentioning

confidence: 99%

“…Tea derived from banaba leaves has historically been used in Southeast Asia to treat diabetes mellitus. Recent studies have reported the anti-diabetic, anti-inflammatory, antioxidant, antiviral, and antifibrotic potential of EBLE in animal studies [11]. Ethanolic extract of banaba petals was shown to possess antioxidant and free radical scavenging properties in carbon tetrachloride-induced liver injury in mice [12].…”

Section: Introductionmentioning

confidence: 99%

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Lagerstroemia speciosa Pers. (Lythraceae) Ethanolic Extract Attenuates Isoniazid-Induced Oxidative Stress and Hepatic Inflammation in Rats

Rohit Singh,

Ezhilarasan,

Karthick

et al. 2024

Cureus

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BackgroundDrug-induced liver injury is a common cause of acute liver failure. Isoniazid (INH) is used as a first-line treatment for tuberculosis. Clinical and experimental studies have reported abnormal liver function after INH therapy. Lagerstroemia speciosa Pers., commonly known as banaba, has been traditionally used to treat various ailments including diabetes and obesity due to its antioxidant and anti-inflammatory properties. AimTo investigate the hepatoprotective effect of ethanolic banaba leaf extract (EBLE) against INH-induced hepatotoxicity in rats. Materials and methodsA total of 30 male Wistar albino rats (150 -200 g) were divided into five groups (n = 6). Group I rats were served as a control and were administered dimethyl sulfoxide for the first 30 days and water for the next 30 consecutive days. Group II rats were administered INH (50 mg/kg, p.o.) once in the first 30 consecutive days and sacrificed at Day 30. Group III rats were administered INH for 30 consecutive days and left without treatment for the next 30 days. In Groups IV and V, rats were post-treated orally with EBLE 250 and 500 mg/kg, p.o. (0.3 ml/rat) for 30 days after INH administration. At the end of Day 60, the remaining group of animals were sacrificed. The blood and liver tissues were collected. The marker enzymes of hepatotoxicity, oxidative stress markers, inflammatory markers, and histopathology were analyzed. ResultsINH administration induced significant elevation of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transpeptidase) of hepatotoxicity in the serum. This treatment also increased lipid peroxidation and proinflammatory marker expression (tumor necrosis factor-alpha, transforming growth factor-beta, and nuclear factor kappa B (NF-κB) except inhibitor of NF-κB) and decreased antioxidants such superoxide dismutase, catalase, and glutathione in the liver tissue. All these abnormalities were significantly mitigated after treatment with EBLE. ConclusionThe results of this study suggest that EBLE can be used for INH-induced hepatotoxicity.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lagerstroemia speciosa Pers. (Lythraceae) Ethanolic Extract Attenuates Isoniazid-Induced Oxidative Stress and Hepatic Inflammation in Rats

Rohit Singh,

Ezhilarasan,

Karthick

et al. 2024

Cureus

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“…Furthermore, INH metabolites have been found to induce lipid peroxidation, a process integral to liver cell damage [18]. The ability of plant-based compounds to counteract this lipid peroxidation and protect against hepatocyte injury underscores their potential as adjunct therapies in TB treatment.…”

Section: Figure 2: Effect Of Ethanolic Leaf Extract Of Abutilon Indic...mentioning

confidence: 99%

Evaluation of the Ethanolic Leaf Extract of Abutilon indicum on Isonicotinic Acid Hydrazide-Induced Proinflammatory Marker Gene Expression Changes

Sunil,

Vedavijaya,

Thakur

et al. 2023

Cureus

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Background: Abutilon indicum, widely found in India, Sri Lanka, and parts of America and Malaysia, is renowned for its rich bioactive compounds including alkaloids, flavonoids, and sesquiterpene lactones. Due to its diverse pharmacological potential, it has garnered significant attention in traditional medicine. In particular, the ethanolic leaf extract of Abutilon indicum (ELEAI) has demonstrated anti-inflammatory effects, notably targeting the 5-lipoxygenase enzyme pivotal in inflammatory responses.Objective: This study aimed to elucidate the impact of the ELEAI on proinflammatory marker gene expression induced by isoniazid (INH).Methods: A total of 36 rats were systematically divided into six experimental groups. The control group received DMSO orally for the initial 30 days followed by distilled water for the subsequent 30 days. The INH group received a daily dose of INH (30 mg/kg b.w., i.p.) for 30 days and the rats were then sacrificed on day 30. The ELEAI (250 mg/kg) group was administered INH daily for 30 days, followed by daily post-treatment with ELEAI (250 mg/kg) for another 30 days. Similarly, the ELEAI (500 mg/kg) group received INH daily for 30 days, followed by daily post-treatment with ELEAI (500 mg/kg) for another 30 days. The silymarin (SIL) group was given INH daily for 30 days, followed by post-treatment with SIL at a dose of 100 mg/kg body weight daily for the subsequent 30 days. Finally, the ELEAI (500 mg/kg) alone group was administered distilled water orally for the first 30 days and then received ELEAI at a dose of 500 mg/kg b.w. orally once daily for the next 30 days.Results: Continuous INH exposure for a month led to a pronounced increase in proinflammatory genes like TNF-α, TGF-β, and NF-kB and a decrease in the IkB gene in rat liver tissues. Subsequent treatment with SIL (100 mg/kg) and ELEAI (250 and 500 mg/kg) post-INH exposure resulted in a marked decrease in proinflammatory genes and a surge in IkB expression. Conclusion:The findings suggest that the ELEAI exerts a dose-responsive influence on proinflammatory activities. Notably, A. indicum counteracts inflammation, especially that triggered by bradykinin and prostaglandins. The ELEAI showcases promising therapeutic potential, exhibiting both pro and antiinflammatory properties and antiproliferative characteristics.

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“…Dapsone administration increased serum hepatotoxicity marker enzymes, lipid peroxidation, and pro-inflammatory markers TNF-α and NF-κB and decreased anti-oxidants in liver tissue (superoxide dismutase, catalase, and glutathione). The administration of EBLE, together with silymarin, attenuates these abnormalities, in particular the expression of TNF-α and TGF-β, suggesting their possible use in cases of hepatotoxicity [70] (Table 2).…”

Section: Effects On Dyslipidemia and Hepatic Steatosismentioning

confidence: 99%

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review

Cannarella,

Garofalo,

Calogero

2023

Endocrines

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Corosolic acid (CA), a natural compound derived from the Banaba tree (Lagerstroemia speciosa), has attracted attention for its potential therapeutic properties in the management of metabolic diseases. This narrative review aims to summarize the current evidence on the anti-dyslipidemic, anti-diabetic, and anti-inflammatory effects of CA and to understand the pharmacokinetics and molecular mechanisms through the analysis of preclinical and clinical studies.

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Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats

Cited by 5 publications

References 56 publications

Lagerstroemia speciosa Pers. (Lythraceae) Ethanolic Extract Attenuates Isoniazid-Induced Oxidative Stress and Hepatic Inflammation in Rats

Lagerstroemia speciosa Pers. (Lythraceae) Ethanolic Extract Attenuates Isoniazid-Induced Oxidative Stress and Hepatic Inflammation in Rats

Evaluation of the Ethanolic Leaf Extract of Abutilon indicum on Isonicotinic Acid Hydrazide-Induced Proinflammatory Marker Gene Expression Changes

Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review

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