<i>Latilactobacillus curvatus</i> BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production

Wang, Xing; Dingyun, Li; Meng, Ziqiang; Kiyeop, Kim; Oh, Sejong

doi:10.4014/jmb.2109.09054

Cited by 8 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a mouse model of 14-day dextran sulfate sodium (DSS)-induced colitis, treatment with Lb. curvatus BYB3 significantly reduced the disease activity index, colon length, and weight loss [110]. Oral administration of Lb.…”

Section: Antimicrobial and Antioxidantmentioning

confidence: 92%

A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites

Kim,

Kwon,

Hwang

et al. 2023

Microbiol. Biotechnol. Lett.

View full text Add to dashboard Cite

Kimchi is a traditional Korean dish made with salted fermented vegetables and contains various nutrients and functional substances with potential health benefits. The fermentation process used to make kimchi creates chemical changes in the food, developing nutrients and functional substances that are more easily absorbed and enhanced by the body. Recent studies have shown that several lactic acid bacteria strains isolated from kimchi exhibit probiotic properties and have several health benefiting properties such as such as anticancer, anti-obesity, and anti-constipation; they also promote colon health and cholesterol reduction in in vitro and in vivo experiments, as well as in epidemiological cohort studies. Kimchi contains prebiotics, non-digestible fibers that nourish beneficial gut bacteria; therefore, its intake effectively provides both probiotics and prebiotics for improved gut health and a fortified gut-derived immune system. Furthermore, fermentation of kimchi produces a variety of metabolites that enhance its functionality. These metabolites include organic acids, enzymes, vitamins, bioactive compounds, bacteriocins, exopolysaccharides, and γ-aminobutyric acid. These diverse health-promoting metabolites are not readily obtainable from single food sources, positioning kimchi as a valuable dietary option for acquiring these essential components. In this review, the health functionalities of kimchi ingredients, lactic acid bacteria strains, and health-promoting metabolites from kimchi are discussed for their properties and roles in kimchi fermentation. In conclusion, consuming kimchi can be beneficial for health. We highlight the benefits of kimchi consumption and establish a rationale for including kimchi in a balanced, healthy diet.

show abstract

Section: Antimicrobial and Antioxidantmentioning

confidence: 92%

A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites

Kim,

Kwon,

Hwang

et al. 2023

Microbiol. Biotechnol. Lett.

View full text Add to dashboard Cite

show abstract

“…Recent studies have identified the association between clinically relevant concentrations (1-10 ng/mL) of LPS and intestinal barrier dysfunction under in vivo and in vitro conditions (Guo et al, 2013). In our previous study, Latilactobacillus curvatus BYB3 decreased the disease activity score of dextran sulfate sodium-induced colitis in a mouse model (Wang et al, 2022). Supplementation with indole or using Lactobacillus reuteri with high AhR ligand production can improve some metabolic symptoms (Swimm et al, 2018).…”

Section: Introductionmentioning

confidence: 91%

Metabolites of Latilactobacillus curvatus BYB3 and Indole Activate Aryl Hydrocarbon Receptor to Attenuate Lipopolysaccharide-Induced Intestinal Barrier Dysfunction

Wang¹,

Yong²,

Oh³

2022

Food Sci Anim Resour

Self Cite

View full text Add to dashboard Cite

This study aimed to investigate the effects of the metabolites of Latilactobacillus curvatus BYB3 and indole-activated aryl hydrocarbon receptor (AhR) to increase the tight junction (TJ) proteins in an in vitro model of intestinal inflammation. Western blot analysis showed that the supernatants of L. curvatus BYB3, indole, and the metabolites of indole derivatives reduced lipopolysaccharide (LPS) simulated in Caco-2 cells; this was a result of upregulating the expression of TJ-associated proteins, namely zona occludens-1 (ZO-1) and claudin-1 (CLDN-1), and by suppressing nuclear factor-kappa B (NF-κB) signaling. Immunofluorescence images consistently revealed that LPS disrupted and reduced the expression of TJ proteins, while the metabolites of L. curvatus BYB3 and indole reversed these alterations. The protective effects of L. curvatus BYB3 were observed on the intestinal barrier function when measuring transepithelial electrical resistance. Using HPLC analysis the metabolites, the indole-3-latic acid and indole-3-acetamide concentrations were found to be 1.73±0.27mg/L and 0.51±0.39mg/L, respectively. These findings indicate that the metabolites of L. curvatus BYB3 have increasing mRNA expressions of cytochrome P450 1A1 (CYP1A1) and AhR, and may thus be applicable for therapy of various inflammatory gut diseases as postbiotics.

show abstract

“…EPS-producing L. curvatus strains can prevent the formation of Salmonella enterica serovar Eteritidis biofilm and effectively limit the colonization of pathogenic bacteria ( Redondo et al, 2017 ). In animal investigations, blood levels of IL-6, TNF-R1, TNF-R2, and TNF-α were considerably reduced in mice administered with L. curvatus BYB3, which improved DSS-induced intestinal inflammation ( Wang et al, 2022 ). Meanwhile, L. curvatus GH5L demonstrates antioxidant effects ( Düz et al, 2020 ).…”

Section: Therapeutic Effects Of Probiotics On Ucmentioning

confidence: 99%

Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022

et al. 2023

View full text Add to dashboard Cite

Ulcerative colitis (UC) has become a worldwide public health problem, and the prevalence of the disease among children has been increasing. The pathogenesis of UC has not been elucidated, but dysbiosis of the gut microbiota is considered the main cause of chronic intestinal inflammation. This review focuses on the therapeutic effects of probiotics on UC and the potential mechanisms involved. In animal studies, probiotics have been shown to alleviate symptoms of UC, including weight loss, diarrhea, blood in the stool, and a shortened colon length, while also restoring intestinal microecological homeostasis, improving gut barrier function, modulating the intestinal immune response, and attenuating intestinal inflammation, thereby providing theoretical support for the development of probiotic-based microbial products as an adjunctive therapy for UC. However, the efficacy of probiotics is influenced by factors such as the bacterial strain, dose, and form. Hence, the mechanisms of action need to be investigated further. Relevant clinical trials are currently lacking, so the extension of animal experimental findings to clinical application requires a longer period of consideration for validation.

show abstract

Latilactobacillus curvatus BYB3 Isolated from Kimchi Alleviates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice by Inhibiting IL-6 and TNF-R1 Production

Cited by 8 publications

References 29 publications

A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites

A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites

Metabolites of Latilactobacillus curvatus BYB3 and Indole Activate Aryl Hydrocarbon Receptor to Attenuate Lipopolysaccharide-Induced Intestinal Barrier Dysfunction

Probiotics for the treatment of ulcerative colitis: a review of experimental research from 2018 to 2022

Contact Info

Product

Resources

About