<i>Leptospira interrogans</i>serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay

Hamond, Camila; Silveira, Caroline da Silva; Buroni, Florencia; Suanes, Alejandra; Nieves, Cecilia; Salaberry, Ximena; Aráoz, Virginia; Costa, Ricardo A.; Rivero, Rodolfo; Giannitti, Federico; Zarantonelli, Leticia

doi:10.1111/tbed.13133

Cited by 19 publications

(14 citation statements)

References 30 publications

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“…5 & 1). The recorded observations are similar to those described by Al-Nassir (2014) and Hamond et al, (2019). In the present study, the occurrence of chronic hepatitis at 3.81 per cent might be because of coccidiosis, hemorrhagic septicemia or plant poisoning.…”

Section: Inflammatory Changessupporting

confidence: 92%

See 1 more Smart Citation

Pathomorphological Studies on Hepatic Disorders in Sheep

Kiran¹,

Jayaramu²,

B³

et al. 2020

Int.J.Curr.Microbiol.App.Sci

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Section: Inflammatory Changessupporting

confidence: 92%

“…8). The recorded observations were similar to those described by Zangana and Aziz (2012), Thannon (2018) and Hamond et al, (2019).…”

Section: Degenerative and Necrotic Changessupporting

confidence: 90%

Pathomorphological Studies on Hepatic Disorders in Sheep

Kiran¹,

Jayaramu²,

B³

et al. 2020

Int.J.Curr.Microbiol.App.Sci

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“…In addition to human hosts, there is a variety of animal hosts for pathogenic leptospires with different serovars. So far, at least 200 species of domestic mammals and wild animals covering Pisces, Amphibia, Reptilia, Aves and Mammalia have been confirmed to serve as hosts, although the epidemiology of leptospirosis and the role of animals is complex and highly dependent on the specific serovars (Ballados‐González et al, ; Delooz et al, ; Hamond et al, ; Zhang, Wang, & Yan, ). Rodents and domestic animals (pigs, dogs, cattle, horses and sheep) are considered the main reservoirs for Leptospira infections in humans (Ellis, ; Guernier et al, ; Zhang, Xu, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Leptospirosis trends in China, 2007–2018: A retrospective observational study

Zhang

Zhu

et al. 2019

Transbound Emerg Dis

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Leptospirosis is one of the most common and neglected tropical waterborne diseases in China, causing serious economic losses, and constituting a significant public health threat. Leptospirosis has recently received increased attention and is considered a reemerging infectious disease in many countries. The incidence of leptospirosis among people suggests that occupation, age, season, sex and water recreational activities are significant risk factors. The aim of this study was to describe the epidemiological profiles of leptospirosis in China during the 2007-2018 period. The morbidity data of leptospirosis by age, season (month), gender, occupation and geographic location (different provinces) were obtained from the public health science data centre of China for subsequent epidemiological analysis. The results indicate that the incidence of leptospirosis has shown a slow downward trend from 2007 to 2018, but morbidity rates were still relatively high (0.0660-0.0113). The incidence of leptospirosis varied in different provinces of China; cases localized mainly to the Southern and Central provinces, areas with warm weather and ample rainfall. Older people (aged 60-75), males, farmers, students and field workers were high-risk populations. During the 2007-2018 observation period, morbidity rates increased beginning in May, remained at high levels in August and September and decreased after November. The present investigation highlights the re-emergence of leptospirosis in some provinces of China (especially in Yunnan and Fujian) and shows that leptospirosis remains a serious public health threat. The results of this study should enhance measures taken for the prevention, control, and surveillance of leptospirosis in China.

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“…interrogans serogroup Pomona serovar Kennewicki from naturally infected and asymptomatic sheep (Hamond et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Dynamics of experimental infection with Leptospira serogroup Pomona in different sheep breed

Costa

Morais

Silva

et al. 2021

RSD

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Most of the information about leptospirosis was obtained from experimental infections with rodents, which in spite of being relevant, do not provide all the answers about the disease in animals and human beings, given the variability of interactions which exist between the agent and the different hosts. Therefore, the objective of the present study was to verify the pathogenesis of the infection in native breeds of sheep of Brazil challenged with a strain of the serogroup Pomona. A total of 10 sheep were divided into two groups with five animals according to the breed. In each group four sheep were challenged by intraperitoneal route with a strain of the serogroup Pomona and one was used as control. Sheep were monitored for 60 days, with collection of blood for serologic diagnosis, as well as vaginal fluid and urine for microbiological and molecular analyses. After this period the animals were submitted to euthanasia and necropsy, with collection of tissues for microbiological, molecular and histopathologic diagnosis. All the challenged sheep presented anti-Leptospira antibodies. Crossbred sheep presented a lower concentration of titers and the antibodies were detected for a shorter period of time when compared to the Santa Inês sheep, with statistical difference in the concentration of the titers on the days 15 (p<0.05), 45 (p<0.05) and 60 (p<0.05) post-infection. There was no significant difference between the groups when comparing the positivity rates of the microscopic agglutination test (MAT) (p>0.05). Eight positive reactions in the urine and vaginal fluid PCR were detected in both groups, being four (50%) in urine and four (50%) in the vaginal fluid, however without statistical difference (p>0.05). In both groups there was a greater proportion of PCR positive samples in kidneys (71.4%) in relation to uterus (28.6%), however without significant difference (p>0.05). There was no significant difference between the groups when comparing the positivity rates of the PCR (p>0.05). The isolation of leptospires from the urine and kidney of a crossbred sheep was possible. Therefore, it is possible that the native sheep, especially the crossbred, may have a relation of resistance with strains of the serogroup Pomona. However the intensity and duration of this relation need to be elucidated and longer-lasting investigations of natural and experimental infections are necessary in order to determine the epidemiological nature of this relation.

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Leptospira interrogansserogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay

Cited by 19 publications

References 30 publications

Pathomorphological Studies on Hepatic Disorders in Sheep

Pathomorphological Studies on Hepatic Disorders in Sheep

Leptospirosis trends in China, 2007–2018: A retrospective observational study

Dynamics of experimental infection with Leptospira serogroup Pomona in different sheep breed

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