<i>Lhr</i>and<i>Hmr</i>are required for sister chromatid detachment during anaphase but not for centromere function

Ja, Blum; Bonaccorsi, Silvia; Marzullo, Marta; Palumbo,; Ym, Yamashita; Da, Barbash; Gatti, Maurizio

doi:10.1101/178046

2017

DOI: 10.1101/178046

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LhrandHmrare required for sister chromatid detachment during anaphase but not for centromere function

Blum Ja

Silvia Bonaccorsi

Marta Marzullo

et al.

Abstract: Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hmr)

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The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

Lukacs

Thomae

Krueger

et al. 2021

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Postzygotic isolation by genomic conflict is a major cause for the formation of species. Despite its importance, the molecular mechanisms that result in the lethality of interspecies hybrids are still largely unclear. The genus Drosophila, which contains over 1600 different species, is one of the best characterized model systems to study these questions. We showed in the past that the expression levels of the two hybrid incompatibility factors Hmr and Lhr diverged in the two closely related Drosophila species, D. melanogaster and D. simulans, resulting in an increased level of both proteins in interspecies hybrids. This overexpression leads to mitotic defects, a misregulation in the expression of transposable elements and a decreased fertility. In this work, we describe a distinct six subunit Speciation Core Complex (SCC) containing HMR and LHR and analyse the effect of Hmr mutations on complex function and integrity. Our experiments suggest that HMR acts as a bridging factor between centromeric chromatin and pericentromeric heterochromatin, which is required for both its physiological function and its ability to cause hybrid male lethality.

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The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

Lukacs

Thomae

Krueger

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

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LhrandHmrare required for sister chromatid detachment during anaphase but not for centromere function

Abstract: Crosses between Drosophila melanogaster females and Drosophila simulans males produce hybrid sons that die at the larval stage. This hybrid lethality is suppressed by loss-of-function mutations in the D. melanogaster Hybrid male rescue (Hmr)

Cited by 1 publication

References 56 publications

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

The Integrity of the Speciation Core Complex is necessary for centromeric binding and reproductive isolation inDrosophila

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