<i>Ligilactobacillus salivarius</i> CCFM 1266 modulates gut microbiota and GPR109a-mediated immune suppression to attenuate immune checkpoint blockade-induced colitis

Yan, Shikai; Yu, Leilei; Tian, Fengwei; Zhao, Jianxin; Chen, Wei; Chen, Haiqin; Zhai, Qixiao

doi:10.1039/d3fo03867j

Food Funct.

2023

DOI: 10.1039/d3fo03867j

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Ligilactobacillus salivarius CCFM 1266 modulates gut microbiota and GPR109a-mediated immune suppression to attenuate immune checkpoint blockade-induced colitis

Shikai Yan,

Leilei Yu,

Fengwei Tian

et al.

Abstract: L. salivarius CCFM 1266 attenuates ICB-induced colitis via gut microbiota modulation, enhancing Treg, M2 macrophages, and IL-10. Nicotinic acid and GPR109a potentially mediate its effects, preserving antitumor immunity in ICB therapy.

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Ligilactobacillus salivarius CCFM 1266 modulates gut microbiota and GPR109a-mediated immune suppression to attenuate immune checkpoint blockade-induced colitis

Abstract: L. salivarius CCFM 1266 attenuates ICB-induced colitis via gut microbiota modulation, enhancing Treg, M2 macrophages, and IL-10. Nicotinic acid and GPR109a potentially mediate its effects, preserving antitumor immunity in ICB therapy.

Cited by 4 publications

References 46 publications

Metabolomic analysis reveals Ligilactobacillus salivarius CCFM 1266 fermentation improves dairy product quality

Metabolomic analysis reveals Ligilactobacillus salivarius CCFM 1266 fermentation improves dairy product quality

Polysaccharides from Yupingfeng granules ameliorated cyclophosphamide-induced immune injury by protecting intestinal barrier

Codonopsis pilosula polysaccharide alleviates ulcerative colitis by modulating gut microbiota and SCFA/GPR/NLRP3 pathway

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