<i>Ligusticum chuanxiong</i>Hort: A review of chemistry and pharmacology

Ran, Xia; Ma, Li; Peng, Cheng; Zhang, Hong; Qin, Lu‐Ping

doi:10.3109/13880209.2011.576346

Cited by 172 publications

(106 citation statements)

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“…6) Its effects are mainly related to its antioxidative, anti-apoptosis, and anti-inflammatory actions. 7) Recent studies have demonstrated that TMP can inhibit cell apoptosis under various conditions, such as hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells 8) and in PC12 cells, 9) oxygen-glucose deprivation-induced neuronal apoptosis, 10) hypoxia-induced myocardial cell apoptosis, 11) and CoCl 2 -induced oxidative stress in PC12 cells. 12) These findings suggest that TMP pretreatment may enhance the survival of transplanted BMSCs and promote brain repair after stroke.…”

mentioning

confidence: 99%

Tetramethylpyrazine Protects Bone Marrow-Derived Mesenchymal Stem Cells against Hydrogen Peroxide-Induced Apoptosis through PI3K/Akt and ERK1/2 Pathways

Yan

Chu

et al. 2017

Biological & Pharmaceutical Bulletin

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Bone marrow-derived mesenchymal stem cells (BMSCs) transplantation is one of the new therapeutic strategies for treating ischemic stroke. However, the poor survival rate of transplanted BMSCs in ischemic tissue limits the therapeutic efficacy of this approach. Oxidative stress is a major mechanism underlying the pathogenesis of brain ischemia and has a negative impact on the survival of transplanted BMSCs. Tetramethylpyrazine (TMP) has been reported to possess potent antioxidant activity. In the present study, we aimed to investigate the protective effects of TMP pretreatment on BMSCs survival of hydrogen peroxide (H 2 O 2 )-induced apoptosis in vitro and to elucidate the potential antiapoptotic mechanisms of TMP pretreatment on BMSCs. BMSCs were pretreated with TMP (10, 25, 50, 100, and 200 µmol/L) for 24 h and then exposed to 500 µmol/L of H 2 O 2 for 24 h. We found that TMP pretreatment significantly increased cell viability and decreased cell apoptosis and intracellular reactive oxygen species (ROS) generation. Furthermore, the protective effects of TMP were related to increased Bcl-2 expression, attenuated Bax expression, and enhanced levels of phosphorylated Akt (p-Akt) and extracellular regulated protein kinases1/2 (p-ERK1/2). Further studies found that these beneficial effects of TMP were significantly blocked by wortmannin (an inhibitor of phosphoinositide-3 kinase (PI3K)) or PD98059 (an inhibitor of ERK1/2). In conclusion, our results confirm that TMP protects BMSCs against H 2 O 2 -induced apoptosis by regulating the PI3K/Akt and ERK1/2 signaling pathways, suggesting that TMP may be used in combination with BMSCs to improve cell survival for the treatment of ischemic stroke.Key words tetramethylpyrazine; bone marrow-derived mesenchymal stem cell; apoptosis; oxidative stress; phosphoinositide 3-kinase/Akt (PI3K/Akt); extracellular regulated protein kinases1/2 (ERK1/2) Ischemic stroke is one of leading causes of death and disability worldwide. Recently, basic and clinical studies have found that the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is a promising therapeutic strategy for brain tissue repair following brain ischemia.

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confidence: 99%

Tetramethylpyrazine Protects Bone Marrow-Derived Mesenchymal Stem Cells against Hydrogen Peroxide-Induced Apoptosis through PI3K/Akt and ERK1/2 Pathways

Yan

Chu

et al. 2017

Biological & Pharmaceutical Bulletin

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“…For the assessment of cognitive recovery (i.e. Morris water maze (MWM) trial), deprivation of injection administration on the same day of the TBI procedure was specified as TMP (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) group (n=6) and vehicle (2-14) group (n=6). All procedures were approved by the Soochow University Animal Ethics Committee and conformed to the Guide for the Care and Use of Laboratory Animals.…”

Section: Experimental Animals and Drug Administrationmentioning

confidence: 99%

“…Additionally, compared with those of the vehicle group, the latency times in the hidden platform test were significantly decreased in the TMP group (P<0.05). When the injection administration on the same day as CCI procedure was not applied in the TMP and vehicle groups [TMP (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and vehicle (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)], a significant difference in latency time in the hidden platform test was not detected. Furthermore, in the spatial probe trial, on PID21 after CCI injury (~2 h after the fifth hidden platform trial), the TMP and vehicle groups demonstrated significantly worse performances than the sham group (P<0.05; Fig.…”

Section: Spatial Learning and Memory Following CCI Injurymentioning

confidence: 99%

“…Ligusticum chuanxiong Hort, also known as L. wallichii Franchat (Chuan Xiong), belongs to the family of Umbelliferae and its rhizome part has been traditionally applied for treating a range of nervous and cardiovascular system diseases in Traditional Chinese Medicine for hundreds of years (7). To date, >200 compounds have been isolated from this plant, which may be categorized into five major groups, namely phenols and organic acids, phthalides, alkaloids, polysaccharides, ceramides and cerebrosides (8).…”

Section: Introductionmentioning

confidence: 99%

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Tetramethylpyrazine reduces blood-brain barrier permeability associated with enhancement of peripheral cholinergic anti-inflammatory effects for treating traumatic brain injury

Wang

Zhu

Qian

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Traumatic brain injury (TBI) is a diverse group of intracranial injuries resulting from external mechanical insults to the brain. While basic and clinical research for TBI has been conducted for decades, it has not identified cost-effective medical interventions for treating TBI. Tetramethylpyrazine (TMP), which is derived from the Chinese herb, Ligusticum chuanxiong Hort (Chuan Xiong), has been clinically used for treating ischemic brain injury for years. However, whether TMP could provide effective benefits for improving the outcomes following TBI is unknown. In the present study, using controlled cortical impact (CCI) injury to create an animal model of TBI, the potential effects of TMP on improving blood-brain barrier (BBB) permeability in the early phase of the secondary injury, as well as the splenic anti-inflammatory activities, were evaluated. Cognitive functions were also assessed by Morris water maze trials following TBI. Results demonstrated that, at 24 h after CCI injury, BBB permeability was significantly reduced (P<0.05) by the application of TMP. In addition, within 24 h after CCI injury, the plasma levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-α, and protein and mRNA expression levels of IL-1β and TNF-α in the spleen were significantly lowered by TMP (P<0.05). Furthermore, within 24 h after CCI injury, the activation of the splenic anti-inflammatory effects mediated by nicotinic acetylcholine receptor α7 (nAChRa7) stimulation were significantly enhanced by TMP (P<0.05). Additionally, impaired spatial memory acquisition and consolidation were significantly improved by TMP after CCI injury (P<0.05). Together, in light of these data, in the treatment of TBI, TMP could effectively reduce BBB permeability, which may be closely associated with the enhanced splenic anti-inflammatory effects activated by nAChRa7 stimulation, and potentially improve cognitive recovery concerning spatial learning and memory.

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“…A Chinese herbal medicine, Ligusticum chuanxiong hort contains FA as one of the active ingredients and has been reported to possess a wide range of pharmacological properties (Ran et al 2011). It is clinically used to treat angina pectoris and hypertensive diseases in China.…”

Section: Introductionmentioning

confidence: 99%

Ferulic acid impairs osteoclast fusion and exacerbates survival of mature osteoclasts

et al. 2016

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Elevated bone loss induced by osteoclasts is a critical and most commonly observed pathological complication during osteolytic diseases such as osteoporosis. Hence, attenuation of osteoclast formation or function is a classical therapeutic approach to regulate bone loss. In this study, we found that ferulic acid (FA), a natural compound potently inhibited osteoclast formation in human CD14? peripheral blood monocytes ex vivo with an IC 50 of 39 lM. Moreover, due to impaired differentiation of osteoclast progenitors, actin ring formation and bone resorption activity were also perturbed. Investigation of underlying molecular mechanisms revealed that FA inhibited the RANKLinduced expression of dendritic cell-specific transmembrane protein (DC-STAMP), a critical regulator of osteoclast fusion. In addition, expression of matrix metalloproteinase-9 (MMP-9) and cathepsin K, the key osteoclast specific lysosomal proteases involved in bone matrix resorption were severely aggravated by FA. A significant reduction in mature osteoclast numbers was detected in the presence of FA accompanied by increased caspase-3 activity and DNAfragmentation, a characteristic hallmark of apoptosis. Collectively, these results suggested that FA inhibited osteoclast fusion by suppressing the expression of DC-STAMP and induced apoptosis in mature osteoclasts by the caspase-3 pathway.

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Ligusticum chuanxiongHort: A review of chemistry and pharmacology

Cited by 172 publications

References 53 publications

Tetramethylpyrazine Protects Bone Marrow-Derived Mesenchymal Stem Cells against Hydrogen Peroxide-Induced Apoptosis through PI3K/Akt and ERK1/2 Pathways

Tetramethylpyrazine Protects Bone Marrow-Derived Mesenchymal Stem Cells against Hydrogen Peroxide-Induced Apoptosis through PI3K/Akt and ERK1/2 Pathways

Tetramethylpyrazine reduces blood-brain barrier permeability associated with enhancement of peripheral cholinergic anti-inflammatory effects for treating traumatic brain injury

Ferulic acid impairs osteoclast fusion and exacerbates survival of mature osteoclasts

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