LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population

Abstract

Neuroblastoma is one of the most commonly diagnosed extracranial solid tumors in infancy; however, the etiology of neuroblastoma remains largely unknown. Previous genome-wide association study (GWAS) indicated that several common genetic variations (rs110419 A > G, rs4758051 G > A, rs10840002 A > G and rs204938 A > G) in the LIM domain only 1 (LMO1) gene were associated with neuroblastoma susceptibility. The aim of this study was to evaluate the correlation between the four GWAS-identified LMO1 gene polymorphisms and neuroblastoma risk in a Southern Chinese population. We genotyped the four polymorphisms in 256 neuroblastoma cases and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. False-positive report probability was calculated for all significant findings. We found that the rs110419 A > G polymorphism was associated with a significantly decreased neuroblastoma risk (AG vs. AA: adjusted OR = 0.65, 95% CI = 0.47–0.91; GG vs. AA: adjusted OR = 0.58, 95% CI = 0.36–0.91; AG/GG vs. AA: adjusted OR = 0.63, 95% CI = 0.46–0.86), and the protective effect was more predominant in children of age > 18 months, males, subgroups with tumor in adrenal gland and mediastinum, and patients in clinical stages III/IV. These results suggested that LMO1 gene rs110419 A > G polymorphism may contribute to protection against neuroblastoma. Our findings call for further validation studies with larger sample size.

HOTAIR gene polymorphisms contribute to increased neuroblastoma susceptibility in Chinese children

“…The second was conducted in Guangdong province (south China), which included 275 cases and 531 controls. The recruitment procedure and criteria for all subjects were described previously . In brief, we identified 275 histologically confirmed neuroblastoma cases among Guangdong residents from the Guangzhou Women and Children's Medical Center between February 2010 and March 2017.…”

“…The recruitment procedure and criteria for all subjects were described previously. [44][45][46] In brief, we identified 275 histologically confirmed neuroblastoma cases among Guangdong residents from the Guangzhou Women and Children's Medical Center between February 2010 and March 2017. During the same period, 531 age-matched, sex-matched, and ethnicity-matched control subjects also were collected from the same hospital.…”

Lack of Associations betweenXPCGene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population

“…A total of 256 newly diagnosed and histopathologically confirmed neuroblastoma cases were recruited from the Guangzhou Women and Children's Medical Center between February 2010 and November 2015 [33–35]. During the same period, 531 healthy children were randomly selected as the age- and gender-matched controls after receiving routine physical examination [35–37].…”

“…During the same period, 531 healthy children were randomly selected as the age- and gender-matched controls after receiving routine physical examination [35–37]. Both the cases and the controls were unassociated ethnic Chinese Han individuals.…”

LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta‐analysis of case‐control studies

“…In addition, the rs2168101 and rs3750952 polymorphisms were markedly associated with decreased NB susceptibility in children from North and South China. 29 A significant association between the rs204926 variant and NB susceptibility has been reported, 32 and rs4758051 and rs10840002 polymorphisms were associated with decreased NB. 29 A significant association between the rs204926 variant and NB susceptibility has been reported, 32 and rs4758051 and rs10840002 polymorphisms were associated with decreased NB.…”