<i>LncRNA‐H19</i> gene plays a significant role in regulating glioma cell function

Liu, Ping; Huang, Xinqiong; Wu, Haijian; Yin, Guoling; Shen, Liangfang

doi:10.1002/mgg3.1480

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…These findings were consistent with the results of Gao’s 47 on the induction of G1/S arrest in AGS cells upon H. pylori infection. H19 knockdown cells showed an increase in S phase and G2, consistent with the observations made by Ping Liu et al 48 in their study on glioma cells after knockdown of H19. Further analysis showed that H19 knockdown alleviated GZ7/cagA infection-induced S phase arrest and facilitated cell entry into the G2 phase, thereby improving cell cycle progression.…”

Section: Discussionsupporting

confidence: 91%

A prominent role of LncRNA H19 in H. pylori CagA induced DNA damage response and cell malignancy

He,

Huang,

Wang

et al. 2024

Sci Rep

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Helicobacter pylori (H. pylori), together with its CagA, has been implicated in causing DNA damage, cell cycle arrest, apoptosis, and the development of gastric cancer. Although lncRNA H19 is abundantly expressed in gastric cancer and functions as a pro-oncogene, it remains unclear whether lncRNA H19 contributes to the oncogenic process of H. pylori CagA. This study investigates the role of H19 in the DNA damage response and malignancy induced by H. pylori. It was observed that cells infected with CagA+H. pylori strain (GZ7/cagA) showed significantly higher H19 expression, resulting in increased γH2A.X and p-ATM expression and decreased p53 and Rad51 expression. Faster cell migration and invasion was also observed, which was reversed by H19 knockdown in H. pylori. YWHAZ was identified as an H19 target protein, and its expression was increased in H19 knockdown cells. GZ7/cagA infection responded to the increased YWHAZ expression induced by H19 knockdown. In addition, H19 knockdown stimulated cells to enter the G2-phase and attenuated the effect of GZ7/cagA infection on the cellular S-phase barrier. The results suggest that H. pylori CagA can upregulate H19 expression, participate in the DNA damage response and promote cell migration and invasion, and possibly affect cell cycle arrest via regulation of YWHAZ.

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Section: Discussionsupporting

confidence: 91%

A prominent role of LncRNA H19 in H. pylori CagA induced DNA damage response and cell malignancy

He,

Huang,

Wang

et al. 2024

Sci Rep

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“…lncRNA RP11-390F4.3 is induced by hypoxia/HIF-1 α and is essential for hypoxia-induced EMT and metastasis by activating multiple EMT regulators [ 33 ]. Suppressing the expression of lncRNA-H19 can reduce the invasive behavior of glioma cells [ 34 ]. GAS8-AS1 overexpression inhibits GBM cell proliferation and invasion by downregulating NEAT1 and achieves the purpose of inhibiting the proliferation of glioblastoma cells [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer

Wang

Chen

et al. 2022

Disease Markers

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The role of 5-methylcytosine-related long noncoding RNAs (m5C-lncRNAs) in bladder cancer (BLCA) remains unclear. Here, we aim to study the prognostic value, gene expression characteristics, and correlation between the m5C-lncRNA risk model and the tumor microenvironment, immune infiltration, and tumor mutations in BLCA. After collecting BLCA patient RNA sequence transcriptome data, clinical information and mutation data from the Cancer Genome Atlas (TCGA) database, 17 m5C-related lncRNAs independently correlated with OS were obtained by Lasso and multivariate Cox regression analysis, and a risk model was constructed. Univariate Cox, multivariate Cox regression analysis, and the C-index curve proved that the risk model was a significant independent prognostic indicator for patients with BLCA. ESTIMATE and CIBERSORT indicated that the higher the number of immune cells and stromal cells in TME, the higher the prognostic risk. We found that in the low-risk group, the expression levels of immune cells that predicted a good prognosis were higher, including plasma cells, regulatory T cells, and CD 8 T cells. There is a negative correlation between TMB and risk score. The TMB of the low-risk group is significantly higher than that of the high-risk group. In conclusion, the m5C-related risk model is crucial to predict the prognosis of patients with BLCA.

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Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells

Stojković

Kostić

Lupšić

et al. 2023

Bioorganic Chemistry

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LncRNA‐H19 gene plays a significant role in regulating glioma cell function

Cited by 5 publications

References 25 publications

A prominent role of LncRNA H19 in H. pylori CagA induced DNA damage response and cell malignancy

A prominent role of LncRNA H19 in H. pylori CagA induced DNA damage response and cell malignancy

5-Methylcytosine-Related Long Noncoding RNAs Are Potential Biomarkers to Predict Overall Survival and Regulate Tumor-Immune Environment in Patients with Bladder Cancer

Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells

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