<i>Loranthus micranthus</i>nanoparticles abates streptozotocin‐instigated testicular dysfunction in Wistar rats: Involvement of glucose metabolism enzymes, oxido‐inflammatory stress, steroidogenic enzymes/protein and Nrf2 pathway

Ebokaiwe, Azubuike Peter; Osawe, Sharon; Griffin, Sharoon; Keck, Cornelia M.; Olusanya, Olasehinde; Ehiri, Richard C.

doi:10.1111/and.13749

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…In recent studies by Griffin et al it was shown that various plant materials can be rendered into nanosized particles by using a combination of high speed stirring (HSS) and high pressure homogenization techniques (HPH) [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Diminution of plant materials to sizes < 10 µm means that all plant cells, which typically possess sizes > 10 µm, are destroyed.…”

Section: Introductionmentioning

confidence: 99%

“…The equipment required is low-cost, freely available and meanwhile established in many laboratories world-wide [ 10 , 11 , 12 , 13 , 14 ]. The feasibility of the PlantCrystal technology was proven in previous studies, where PlantCrystals were shown to increase the antimicrobial and antifungal activity of various plant materials [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Their feasibility to improve antioxidative capacity has not yet been investigated and a systematic study investigating the influence of plant material and process parameters on PlantCrystal size and properties is also not yet available.…”

Section: Introductionmentioning

confidence: 99%

“…The study was conducted in three steps. In the first step PlantCrystals were produced by using the previously applied production techniques, i.e., a combination of high speed stirring and high-pressure homogenization and subsequent freeze drying [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Different plant materials (leaves, seeds) with well-known antioxidative properties were selected and rendered into PlantCrystals.…”

Section: Introductionmentioning

confidence: 99%

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PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

et al. 2020

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PlantCrystals are obtained by milling plant material to sizes <10 µm. Due to the disruption of the plant cells, active compounds are easily released, rendering the PlantCrystal technology an effective and low-cost process for the production of environmentally friendly plant extracts. The extracts can be used to produce phytomedicines, nutritional supplements or cosmetic products. Previous studies could already demonstrate the use of PlantCrystals to improve the antimicrobial or antifungal activity of different plants. This study investigated whether PlantCrystal technology is suitable to produce plant derived formulations with high antioxidant capacity. The study also aimed to identify the most suitable production methods for this. Methods: Various plant materials and parts of plants, i.e., seeds, leaves and flowers, and different methods were employed for the production. PlantCrystals were characterized regarding size, physical stability and antioxidant capacity (AOC). Results: PlantCrystals with particles <1 µm were produced from the different plant materials. Both production methods, i.e., high-pressure homogenization, bead milling or the combination of both were suitable to obtain PlantCrystals. Nano milling of the plant material greatly affected their AOC and resulted in formulations with distinctly higher AOC when compared to classical extracts. Conclusions: Rendering plant material into small sized particles is highly effective to obtain plant extracts with high biological efficacy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

et al. 2020

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“…Melatonin ameliorates ATR-induced mitochondrial dysfunction and steroid disorders in GCs via the ROS/SIRT1/STAR axis ( Li et al, 2024 ). Similarly, Loranthus micranthus nanoparticles can alleviate testicular dysfunction in rats via the steroidogenic enzymes/protein and Nrf2 pathways ( Ebokaiwe et al, 2020 ). However, the specific role of the Nrf2/ARE pathway in regulating ATR-mediated reproductive disorders remains unclear.…”

Section: Introductionmentioning

confidence: 99%

The Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells

Li,

Guo,

Wang

et al. 2024

Poultry Science

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“…The destruction of the plant cells and organelles allows for a fast and exhaustive extraction of plant constituents without the need of organic solvents ( Figure 1 ). Thus, the PlantCrystal-technology is considered to be a novel, environmentally friendly plant extraction process; the suitability of the technology over classical extraction methods was already proven in various recent studies [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. These studies could, for example, show an enhanced extraction efficacy, especially for lipophilic compounds when compared to classical extraction methods and could also demonstrate an improved therapeutic efficacy when compared to classical extracts.…”

Section: Introductionmentioning

confidence: 99%

Cucumber-Derived Exosome-like Vesicles and PlantCrystals for Improved Dermal Drug Delivery

et al. 2022

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(1) Background: Extracellular vesicles (EVs) are considered to be efficient nanocarriers for improved drug delivery and can be derived from mammalian or plant cells. Cucumber-derived EVs are not yet described in the literature. Therefore, the aim of this study was to produce and characterize cucumber-derived EVs and to investigate their suitability to improve the dermal penetration efficacy of a lipophilic active ingredient (AI) surrogate. (2) Methods: The EVs were obtained by classical EVs isolation methods and by high pressure homogenization (HPH). They were characterized regarding their physico-chemical and biopharmaceutical properties. (3) Results: Utilization of classical isolation and purification methods for EVs resulted in cucumber-derived EVs. Their dermal penetration efficacy for the AI surrogate was 2-fold higher when compared to a classical formulation and enabled a pronounced transdermal penetration into the viable dermis. HPH resulted in submicron sized particles composed of a mixture of disrupted plant cells. A successful isolation of pure EVs from this mixture was not possible with classical EVs isolation methods. The presence of EVs was, therefore, proven indirectly. For this, the lipophilic drug surrogate was admixed to the cucumber juice either prior to or after HPH. Admixing of the drug surrogate to the cucumber prior to the HPH resulted in a 1.5-fold increase in the dermal penetration efficacy, whereas the addition of the AI surrogate to the cucumber after HPH was not able to improve the penetration efficacy. (4) Conclusions: Results, therefore, indicate that HPH causes the formation of EVs in which AI can be incorporated. The formation of plant EVs by HPH was also indicated by zeta potential analysis.

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Loranthus micranthusnanoparticles abates streptozotocin‐instigated testicular dysfunction in Wistar rats: Involvement of glucose metabolism enzymes, oxido‐inflammatory stress, steroidogenic enzymes/protein and Nrf2 pathway

Abstract: Therefore, production of plant nanoparticles with known therapeutic potentials is a need of the moment and has prompted the current

Cited by 9 publications

References 32 publications

PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

PlantCrystals—Nanosized Plant Material for Improved Bioefficacy of Medical Plants

The Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells

Cucumber-Derived Exosome-like Vesicles and PlantCrystals for Improved Dermal Drug Delivery

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