2021
DOI: 10.1111/jcmm.17106
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LOXL1‐AS1 communicating with TIAR modulates vasculogenic mimicry in glioma via regulation of the miR‐374b‐5p/MMP14 axis

Abstract: At present, growing evidence indicates that long non‐coding RNAs (lncRNAs) participate in the progression of glioma. The function of LOXL1‐AS1 in vasculogenic mimicry (VM) in glioma remains unclear. First, the expressions of TIAR, the lncRNA LOXL1‐AS1, miR‐374b‐5p and MMP14 were examined by qRT‐PCR and Western blot in both, glioma tissues and glioma cell lines. Proliferation, migration, invasion and tube formation assays were conducted to evaluate the roles of TIAR, LOXL1‐AS1, miR‐374b‐5p and MMP14 in malignan… Show more

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Cited by 16 publications
(10 citation statements)
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“…Some relevant examples include iNOS [ 70 ], TPD52 [ 71 ] and alpha-synuclein [ 60 ] mRNAs. Stability/turnover events can involve RNAs and SGs [ 72 ], and also non-coding RNAs (lncRNAs/miRNAs) [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ]. An example of this is the Hippo pathway, which is a regulator of organ growth and tumorigenesis.…”
Section: Phylogenetics and Cellular/tissular Expression Profilingmentioning
confidence: 99%
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“…Some relevant examples include iNOS [ 70 ], TPD52 [ 71 ] and alpha-synuclein [ 60 ] mRNAs. Stability/turnover events can involve RNAs and SGs [ 72 ], and also non-coding RNAs (lncRNAs/miRNAs) [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ]. An example of this is the Hippo pathway, which is a regulator of organ growth and tumorigenesis.…”
Section: Phylogenetics and Cellular/tissular Expression Profilingmentioning
confidence: 99%
“…For example, the lncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate p53 signaling [ 74 ]. Similarly, the lncRNA PHAROH regulates Myc translation in hepatocellular carcinoma by sequestering TIAL1 [ 75 ], and the lncRNA LOXL1-AS1 interacts with TIAR to modulate vasculogenic mimicry in glioma through the regulation of the miR-374b-5p/MMP14 axis [ 76 ]. Interestingly, several single nucleotide polymorphisms in lncRNA regions found in TIAR are associated with breast cancer risk [ 77 ].…”
Section: Phylogenetics and Cellular/tissular Expression Profilingmentioning
confidence: 99%
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“…NG2/CSPG4 is a malignant marker in CNS cancers such as gliomas, the most common and malignant cancer in the CNS [ 28 ], and it is closely related to poor prognoses as it promotes cancer cell proliferation and motility via its binding to growth factors (bFGF and PDGF-AA) [ 24 ], MMPs [ 29 ], ECM-collagen IV [ 30 ], and integrins [ 31 ], which involves these binding partners in an oncogenic transformation. There is an inverse relationship between the activation of á3â1 integrin-dependent PI3K/Akt signaling promoted by NG2/CSPG4 and apoptosis, as demonstrated by the restoration of apoptosis after siRNA knockdown of NG2/CSPG4 [ 32 ].…”
Section: Initial Discovery Of Ng2/cspg4 As a Precursor Marker In The ...mentioning
confidence: 99%