<i>Lycium schweinfurthii</i>: new secondary metabolites and their cytotoxic activities

Elbermawi, Ahmed; Halim, Ahmed F.; Mansour, El Sayed S.; Ahmad, Kadria F.; Elsbaey, Marwa; Ashour, Ahmed; Amen, Yhiya; El‐Gamil, Mohammed M.; Miyamoto, Tomofumi; Shimizu, Kuniyoshi

doi:10.1080/14786419.2021.1922902

Cited by 13 publications

(13 citation statements)

References 23 publications

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“…These compounds can be easily degraded within the body into the corresponding phenylacetic acid, with consequent loss of activity. Furthermore, the same group in other work [84] isolated more than 28 compounds in all fractions of the same crude methanolic extract. Moreover, the authors evaluated the cytotoxic potential of the isolates in skin cancer (G-361) and colon cancer (HCT-116 and CaCo-2) cell lines (Table 1).…”

Section: Chemical Composition and Biological Propertiesmentioning

confidence: 73%

“…The compounds identified by Elbermawi et al [84] were: vaginatin, 11S-methoxy-11,12-dihydrophytuberin, (E)-docosanoyl ferulate and (Z)-docosanoyl ferulate, β-sitosterol and β-sitosterol-3-O-β-D-glucoside, 9S-methoxy-benzocyclononan-7-one, isoscopoletin, pinoresinol, trans-cinnamoyl tyramine, trans-ferulyl tyramine, trans-ferulyl-3-methoxytyramine, diosmetin, apigenin, luteolin, p-hydroxybenzoic acid, vanillic acid, kampferol, quercetin, methyl-α-D-fructofuranoside, meliasendanin D, trans-ferulic acid, p-coumaric acid, diosmetin-7-O-β-D-glucoside, quercetin-3-O-β-D-glucoside-6-α-D-rhamnoside (rutin), 3-methoxy-4-O-β-D-glucopyranosyl-methylbenzoate, gallic acid, and 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2[4-(3-hydroxy-1-(E)-propenyl)-2-methoxyphenoxy]-propyl-β-D-glucop yranoside (Figure 5). Diosgenin reported previously [81] was not found by the authors [84]. 11S-Methoxy-11,12-dihydrophytuberin and 9S-methoxy-benzocyclononan-7-one were new natural products.…”

Section: Chemical Composition and Biological Propertiesmentioning

confidence: 99%

“…Cytotoxicity NT/>100/>100 [84] NT: not tested; 1: cancer cell lines from skin (G-361); 2: cancer cell lines from colon (HCT-116); 3: cancer cell lines from colon (Caco-2); IC 50 : the concentration of the tested compound (µM) that inhibited the α-glucosidase activity by 50%; or the concentration of the tested compound (µM) that decreased the number of viable cells by 50%.…”

Section: Chemical Composition and Biological Propertiesmentioning

confidence: 99%

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Chemical and Biological Properties of Three Poorly Studied Species of Lycium Genus—Short Review

Miguel

2022

Metabolites

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The genus Lycium belongs to the Solanaceae family and comprises more than 90 species distributed by diverse continents. Lycium barbarum is by far the most studied and has been advertised as a “superfood” with healthy properties. In contrast, there are some Lycium species which have been poorly studied, although used by native populations. L. europaeum, L. intricatum and L. schweinfurthii, found particularly in the Mediterranean region, are examples of scarcely investigated species. The chemical composition and the biological properties of these species were reviewed. The biological properties of L. barbarum fruits are mainly attributed to polysaccharides, particularly complex glycoproteins with different compositions. Studies regarding these metabolites are practically absent in L. europaeum, L. intricatum and L. schweinfurthii. The metabolites isolated and identified belong mainly to polyphenols, fatty acids, polysaccharides, carotenoids, sterols, terpenoids, tocopherols, and alkaloids (L. europaeum); phenolic acids, lignans, flavonoids, polyketides, glycosides, terpenoids, tyramine derivatives among other few compounds (L. schweinfurthii), and esters of phenolic acids, glycosides, fatty acids, terpenoids/phytosterols, among other few compounds (L. intricatum). The biological properties (antioxidant, anti-inflammatory and cytotoxic against some cancer cell lines) found for these species were attributed to some metabolites belonging to those compound groups. Results of the study concluded that investigations concerning L. europaeum, L. intricatum and L. schweinfurthii are scarce, in contrast to L. barbarum.

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Section: Chemical Composition and Biological Propertiesmentioning

confidence: 73%

Section: Chemical Composition and Biological Propertiesmentioning

confidence: 99%

Section: Chemical Composition and Biological Propertiesmentioning

confidence: 99%

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Chemical and Biological Properties of Three Poorly Studied Species of Lycium Genus—Short Review

Miguel

2022

Metabolites

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“…4 L. schweinfurthii was isolated with twenty-six known and two novel compounds, four showed cytotoxic effects against skin cancer cells and three showed cytotoxic effects against colon cancer cells. 5 Our ongoing studies showed that the plant extract has a potent pharmacological activity in experiment animals, including anti-convulsion action (unpublished data). Diazepam belongs to benzodiazepine group which has widely been used to treat general anxiety disorders, muscle relaxant and used as sedative, hypnotic and anticonvulsant.…”

Section: Introductionmentioning

confidence: 94%

Phytochemical and pharmacological studies of Lycium schweinfurthii methanolic leaves extract (Solanaceae) in mice

Sherif¹,

Bazine²,

Shlaka³

et al. 2022

PPIJ

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Lycium schweinfurthii is found in stony and sandy places belonging to the Solanaceae family which is widely distributed in North Africa and Mediterranean area. The leaves and fruits of this plant have traditionally been used for gastrointestinal diseases. This study was aimed to evaluate the neuropharmacological activity of the methanolic extract of Lycium schweinfurthii in experimental animals. The methanolic extract of the leaves was prepared by the fractionation technique. Male Albino mice of 22.2 ± 2.1 gm were used to evaluate the activity of the extract by Irwin primary screening test, diazepam and thiopental -induced sleep and open field apparatus for general locomotor activity as well as analgesic activity was evaluated by acetic acid-induced writhing and hot-plate. The phytochemical screening was performed by qualitative and quantitative analysis. Diazepam at 2 and 20 mg/kg, flumazenil at 2 mg/kg, thiopental at 40 mg/kg, diclofenac at 25 and 50 mg/kg and indomethacin at 20 mg/kg were all used as references. The selected dose of 400 mg/kg of the methanolic extract was selected after the Irwin screening test. Lycium schweinfurthii extract significantly prolonged the duration of diazepam-induced sleep without significant difference in the onset of sleep. Pretreatment with flumazenil completely blocked the hypnotic effects of the plant extract and diazepam. The plant extract with thiopental did not produce any significant change in the onset and duration time of sleep. In an open-field test, a combination of the plant extract with diazepam produced a significant reduction in both exploratory and general locomotor activity which was observed in four min and 30 min, respectively. The plant extract significantly induced a profound central and peripheral analgesic action. While, the phytochemical screening showed presences of flavonoids, tannins, saponins, phenols, cardiac glycoside, alkaloids and carbohydrates in the extract. The total flavonoids were the most content compounds in the extract. Thus, these findings indicate that Lycium schweinfurthii has depression, sedative and analgesic like activities.

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“…Various steps of column chromatography on Dianion HP-20, silica gel and Sephadex LH-20 resulted in the isolation of four phytoconstituents from SSLE. According to their spectral data and the literature data, the isolated phytoconstituents were characterized as hesperetin (3',5,7-trihydroxy-4'-methoxyflavanone), [34] 4hydroxybenzoic acid, [35] 20-(S)-ginsenoside Rg2, [36] quinic acid. [37] This is the first report of their isolation from the genus Sansevieria as far as we know.…”

Section: Phytoconstituents Isolationmentioning

confidence: 99%

Phytoconstituents of Sansevieria suffruticosa N.E.Br. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally Induced Liver Fibrosis Rat Model

Abdel-Rahman¹,

Fayed²,

Ogaly

et al. 2022

Chemistry & Biodiversity

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Sansevieria species possess antioxidant and hepatoprotective activities. However, the therapeutic potential of Sansevieria suffruticosa N.E.Br. in liver fibrosis was not evaluated yet. Twenty‐seven phytoconstituents were tentatively identified in the phytoconstituents profile of Sansevieria suffruticosa N.E.Br. leaves extract (SSLE) using high‐performance liquid chromatography coupled with mass spectrometry (HPLC‐ESI/MS‐MS). Using column chromatography, hesperetin, 4‐hydroxybenzoic acid, ginsenoside Rg2, and quinic acid were isolated from SSLE. The hepatoprotective effect of SSLE via the activation of the NRF2 signaling pathway was evaluated using a rat model of thioacetamide‐induced liver fibrosis. Five groups of 6 male adult Wistar rats were used. All animals except the normal control were injected with 200 mg/kg of TAA intraperitoneally twice weekly for 6 weeks. SSLE‐treated groups were orally administered 200 and 100 mg/kg/day of the extract, two weeks before the liver fibrosis induction and were continued concomitantly with TAA injection. A reference group received 100 mg/kg b.wt of silymarin orally. SSLE treated groups exhibited a marked reduction in serum alanine transaminase (ALT), aspartate transaminase (AST) and malondialdehyde (MDA) levels compared with the TAA group. The levels of reduced glutathione (GSH) content and hepatic mRNA levels of Nrf2 and HO‐1 were significantly increased. Histological findings further confirmed the protective role of SSLE against TAA. In conclusion, the aforementioned results indicated that the hepatoprotective mechanism of SSLE was exerted via activating the Nrf2 pathway to counteract oxidative stress.

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Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities

Cited by 13 publications

References 23 publications

Chemical and Biological Properties of Three Poorly Studied Species of Lycium Genus—Short Review

Chemical and Biological Properties of Three Poorly Studied Species of Lycium Genus—Short Review

Phytochemical and pharmacological studies of Lycium schweinfurthii methanolic leaves extract (Solanaceae) in mice

Phytoconstituents of Sansevieria suffruticosa N.E.Br. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally Induced Liver Fibrosis Rat Model

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