<i>Lymphocytic choriomeningitis virus</i> infection in a province of Spain: Analysis of sera from the general population and wild rodents

Lledó, Lourdes; Gegúndez, María Isabel; Saz, José Vicente; Bahamontes, Noemí; Beltrán, María

doi:10.1002/jmv.10389

Cited by 67 publications

(66 citation statements)

References 16 publications

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“…LCMV is a natural pathogen of both human and murine populations (1). Human transmission has been shown to occur in utero, upon transplantation with infected organs or upon contact with infected hamsters or laboratory animals (2)(3)(4).…”

Section: General Background On Lcmvmentioning

confidence: 99%

Lymphocytic choriomeningitis infection of the central nervous system

Kang

McGavern

2008

Front Biosci

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Viral infection of the central nervous system (CNS) can result in a multitude of responses including pathology, persistence or immune clearance. Lymphocytic choriomeningitis virus (LCMV) is a powerful model system to explore these potential outcomes of CNS infection due to the diversity of responses that can be achieved after viral inoculation. Several factors including tropism, timing, dose and variant of LCMV in combination with the development or suppression of the corresponding immune response dictates whether lethal meningitis, chronic infection or clearance of LCMV in the CNS will occur. Importantly, the functionality and positioning of the LCMV-specific CD8 + T cell response are critical in directing the subsequent outcome of CNS LCMV infection. Although a basic understanding of LCMV and immune interactions in the brain exists, the molecular machinery that shapes the balance between pathogenesis and clearance in the LCMV-infected CNS remains to be elucidated. This review covers the various outcomes of LCMV infection in the CNS and what is currently known about the impact of the virus itself versus the immune response in the development of disease or clearance. KeywordsLCMV; Clone 13; Virus; Meningitis; Immunotherapy; Brain; Neurons; Astrocytes; Immunodeficient; Neonates; Growth Hormone; T cell; behavior; Review INTRODUCTIONThe parameters that dictate pathology versus clearance after CNS viral infection are relatively undefined. The CNS contains highly integrated populations of neurons and glial cells responsible for our livelihood, and immune infiltration has the potential to severely disrupt the function of this sensitive compartment. Consequently, through evolutionary pressures the CNS has become immunologically specialized and now possesses the ability to HHS Public AccessAuthor manuscript Front Biosci. Author manuscript; available in PMC 2017 January 30.Published in final edited form as:Front Biosci. ; 13: 4529-4543. Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript modulate (or suppress) leukocyte behavior in a manner that fundamentally differs from that observed in most peripheral tissues. This evolutionary acquisition, which is advantageous from the standpoint of host survival, likely facilitates the entry and replication of viruses within the CNS. A multitude of viruses have the capacity to gain access to the CNS and upon doing so can establish a chronic infection, drive immunopathology, or alter the function of residents cells, making clearance of the invading pathogen essential. Therefore, a fundamental knowledge of viral-immune interactions in the CNS is essential if we ultimately intend to therapeutically modulate CNS immune responses in humans to achieve viral clearance in the absence of immunopathology. LCMV infection of mice provides an outstanding model system to explore such interactions and extend the lessons learned to virus infections of humans. GENERAL BACKGROUND ON LCMVLCMV is a natural pathogen of both human and murine populations (1). Human transmissio...

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Section: General Background On Lcmvmentioning

confidence: 99%

Lymphocytic choriomeningitis infection of the central nervous system

Kang

McGavern

2008

Front Biosci

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“…LCMV is a rodent-borne virus belonging to the Arenaviridae, genus Arenavirus, and causes the human disease lymphocytic choriomeningitis, which ranges in severity from biphasic flu-like illness to meningitis and encephalitis [20,34]. Intrauterine infections may occur and result in chorioretinitis, hydrocephalus, microcephaly or macrocephaly, mental retardation, and fetal death [16,22,36].…”

Section: Introductionmentioning

confidence: 99%

“…The virus has also been detected in other wild rodents, with prevalence in bank voles reported as 3.3% in the Province of Trento in Italy [17] and 7.4% in northern Italy [38]. In Finland, no previous studies have examined the seroprevalence of LCMV among humans; however, a low seroprevalence for LCMV has been noted among human patients in Spain, Netherlands, Italy, Viet Nam, USA and Canada [8,21,10,20,17,25].…”

Section: Introductionmentioning

confidence: 99%

Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection

Fevola

Forbes

Mäkelä

et al. 2016

Journal of Clinical Virology

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a b s t r a c tBackground: The emergence and re-emergence of zoonotic and vector-borne diseases are increasing in Europe. Prominent rodent-borne zoonotic viruses include Puumala hantavirus (PUUV; the causative agent of nephropathia epidemica, NE), lymphocytic choriomeningitis virus (LCMV), and orthopoxviruses (OPV). In addition, Ljungan virus (LV) is considered a potentially zoonotic virus. Objective: The aim of this study was to compare clinical picture between acute PUUV patients with and without additional rodent-borne viral infections, to investigate if concurrent infections influence disease severity. Study design: We evaluated seroprevalence of and seroconversions to LCMV, LV and OPV in 116 patients hospitalized for NE. Clinical and laboratory variables were closely monitored during hospital care. Results: A total of five LCMV, 15 LV, and one OPV seroconversions occurred. NE patients with LCMV seroconversions were younger, and had lower plasma creatinine concentrations and platelet counts than patients without LCMV seroconversions. No differences occurred in clinical or laboratory findings between patients with and without seroconversions to LV and OPV. We report, for the first time, LCMV seroprevalence in Finland, with 8.5% of NE patients seropositive for this virus. Seroprevalences for LV and OPV were 47.8% and 32.4%, respectively. Conclusion: Cases with LCMV seroconversions were statistically younger, had milder acute kidney injury and more severe thrombocytopenia than patients without LCMV. However, the low number of seroconversion cases precludes firm conclusions. Concurrent LV or OPV infections do not appear to influence clinical picture for NE patients.

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“…In such mice, infectious virus is permanently excreted in the urine, saliva, and milk [16]. From investigations of antibody against LCMV, wild house mice are commonly contaminated with LCMV on a global basis [4,13,15]. These mice become natural reservoirs and could transmit LCMV to laboratory animals [20].…”

Section: Introductionmentioning

confidence: 99%