<i>Magnolia officinalis</i>and Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates

Kim, Hyojin; Lim, Chae Yeon; Chung, Mi Sook

doi:10.1089/fpd.2020.2805

Cited by 18 publications

(16 citation statements)

References 51 publications

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“…It is important to highlight this is the first report of Honokiol's antiviral activity against different alphaviruses. Honokiol and α-Mangostin's antiviral activity against other viruses, such as dengue, CHIKV, human norovirus and herpes simplex virus-1 [54][55][56][57], along with our findings, suggest that these compounds may modulate a general antiviral mechanism. In this sense, Chen and collaborators found that Honokiol and a relatedcompound, Magnolol, enhanced the antiviral response against grass carp reovirus via increased transcription of type I IFN and IFN-stimulated genes in carp kidney cells [62].…”

Section: Discusionsupporting

confidence: 69%

“…Honokiol is a lignan biphenol, whereas α-Mangostin belongs to a class of molecules know as xanthones. These compounds have shown multiple pharmacological activities, including anti-inflammatory [33][34][35], antifungal [36,37], antifibrotic [38,39], antibacterial [40][41][42], antitumoral [43][44][45][46], antioxidant [47,48], anti-depressant [26,49], neuro-and cardio-protective properties [50][51][52][53], as well as antiviral activity against certain viruses [54][55][56][57][58]. However, Sanguinarine, (R)-Shikonin, Fisetin, Tanshinone IIA, Honokiol and α-Mangostin have not been studied extensively in the context of arboviruses.…”

Section: Introductionmentioning

confidence: 99%

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Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Valdes-Torres

Campos

Bhakta

et al. 2022

Preprint

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Mayaro virus (MAYV) is an emerging arbovirus with increasing circulation across the Americas. In the present study, we evaluated the potential antiviral activity of the following natural com-pounds against MAYV and other arboviruses: Sanguinarine, (R)-Shikonin, Fisetin, Honokiol, Tanshinone IIA and alfa-Mangostin. Sanguinarine and Shikonin showed significant cytotoxicity, whereas Fisetin, Honokiol, Tanshinone IIA and alfa-Mangostin were well-tolerated in all the cell lines tested. Honokiol and alfa-Mangostin treatment protected Vero-E6 cells against MAYV-induced damage and resulted in a dose-dependent reduction in viral progeny yields for each of the MAYV strains and human cell lines assessed. Also, Honokiol and alfa-Mangostin disrupted MAYV infection at different stages of the virus life cycle. Moreover, these compounds de-creased Una, Chikungunya and Zika viral titers and downmodulated the expression of E1 and nsP1 viral proteins from MAYV, Una and Chikungunya. Finally, in Honokiol- and alfa-Mangostin-treated cells, we observed an upregulation in the expression of type I interferon and specific interferon-stimulated genes, including IFN-alfa, IFN-beta;, MxA, ISG15, OAS2, MDA-5, TNF-alfa and IL-1beta;, which may promote an antiviral cellular state. Our results indicate that Honokiol and alfa-Mangostin present potential broad-spectrum activity against different arboviruses through a possible modulation of the interferon pathway.

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Section: Discusionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Valdes-Torres

Campos

Bhakta

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Virus infection induces redox imbalance by decreasing GSH levels and enhancing ROS levels [ 44 , 45 , 46 ]. In this study, the AGR extract increased GSH in the MNV-infected cells ( p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the extract showed ferric ion-reducing and DPPH scavenging activities. It was previously reported that the hop extract and Magnolia officinalis extract increases GSH content in virus-infected cells, which inhibits virus replication [ 45 , 46 ]. In this context, it is likely that the AGR extract also ameliorates ROS damage by increasing GSH levels in MNV-infected cells, inhibiting MNV replication.…”

Section: Discussionmentioning

confidence: 99%

Antiviral Activities of Asarones and Rhizomes of Acorus gramineus on Murine Norovirus

Kim

Maeng

Lee

et al. 2022

Viruses

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Noroviruses (NVs) are a major cause of foodborne diseases worldwide. The rhizomes of Acorus gramineus (AGR) have been used as a traditional medicinal plant and a food additive. In this study, AGR and its bioactive components—α-asarone and β-asarone—showed significant antiviral activities against murine NV (MNV) with pre-treatment, with more than two log reductions in viral plaques. They also demonstrated strong inhibition on binding to A- and O-type saliva by the recombinant P domain derived from human NV (HuNV) GII.4. Both α- and β-asarones also inhibited the binding of the P domain to the receptor at 0.125–1 mM in a concentration-dependent manner and induced a marked reduction in Tm, suggesting that they may reduce structural stability and block receptor binding by the P domain. In simulated digestive conditions, the AGR extract, α-asarone, or β-asarone further showed a significant reduction of MNV plaques by 1.5–2.8 logs. The asarones show a potential for development as a scaffold for anti-NV agents.

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“…The two major metabolites, honokiol and magnolol, have wide-ranging pharmacological effects, including antitumorigenic, anti-inflammatory, antithrombotic, antioxidative, and neuroprotective activities ( Honda et al, 2012 ). M. officinalis extract and Honokiol reportedly suppresses against human norovirus surrogates, murine norovirus (MNV) and feline calicivirus (FCV) in vitro , and in model food system ( Kim et al, 2021 ). Honokiol inhibited the furin-like activity and SARS-CoV-2 infection ( Tanikawa et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Chinese herbal prescriptions for COVID-19 management: Special reference to Taiwan Chingguan Yihau (NRICM101)

Huang

Lin

2022

Front. Pharmacol.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. As at June 2022, increasing numbers of newly diagnosed COVID-19-associated pneumonia cases worldwide have attracted close attention from the international community. The present review analyzes and summarizes the treatment of COVID-19 with traditional Chinese medicine (TCM). A systematic analysis of the efficacies and benefits of TCM for the treatment of COVID-19 was performed, and the mechanisms underlying such treatment are summarized. This analysis of the literature highlights the potential of TCM to prevent and treat COVID-19 via antiviral, anti-inflammatory and immunomodulatory activities, with evidence showing that many TCM components act upon multiple targets and pathways. Famous TCM formulas include Qing-Fei-Pai-Du-Tang (QFPDT), Lianhuaqingwen Capsule (LHC), Taiwan Chingguan Yihau (NRICM101), and Jing Si herbal drink (JSHD). In particular, the botanical preparation NRICM101 was developed in 2020 for use in viral respiratory tract infections and is recommended for treating non-severe and mild COVID-19 infections. NRICM101 has been adopted for use in Taiwan for the clinical treatment of COVID-19. The common components and active ingredients of 10 TCM preparations have been analyzed for the most promising substances. This review aims to provide reliable evidence demonstrating the therapeutic efficacy of TCM substances in support of their further development against novel coronavirus infectious diseases in Taiwan.

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Magnolia officinalisand Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates

Cited by 18 publications

References 51 publications

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Honokiol and alfa-Mangostin inhibit Mayaro virus replication by stimulating the type I interferon pathway

Antiviral Activities of Asarones and Rhizomes of Acorus gramineus on Murine Norovirus

Chinese herbal prescriptions for COVID-19 management: Special reference to Taiwan Chingguan Yihau (NRICM101)

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