mcr-1
 in Multidrug-Resistant
 bla
 KPC-2
 -Producing Clinical Enterobacteriaceae Isolates in Singapore

Teo, Jin Yao; Ong, Rick Twee‐Hee; Xia, Eryu; Koh, Tse-Hsien; Khor, Chiea‐Chuen; Lee, Shannon Jing-Yi; Lim, Tze-Peng; Kwa, Andrea Lay-Hoon

doi:10.1128/aac.00804-16

Cited by 30 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, this report confirms the global spread of mcr . Notably we did not find the co-existence of mcr with any carbapenemase genes, although co-carriage is being increasingly reported, including mcr -1 with bla NDM in Enterobacteriaceae from the U.S. and China [ 32 , 42 – 46 ], as well as mcr- 1 and bla KPC in isolates from Singapore [ 47 ]. Continual surveillance of this recently recognized threat to public health is warranted as MDR bacteria that acquire mcr will leave few treatment options.…”

Section: Resultsmentioning

confidence: 90%

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Wise¹,

Estabrook²,

Sahm³

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

A set of 908 clinically derived colistin-resistant Enterobacteriaeae isolates collected worldwide in 2014–2016 were screened for the presence of the plasmid-borne mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 genes. In total 3.2% (29/908) of the collection were positive for mcr, including 27 Escherichia coli, 1 Klebsiella pneumoniae and 1 Enterobacter cloacae. Twenty-four isolates possessed genes from the mcr-1 family, including the original mcr-1 (n = 22), as well as mcr-1.2 (n = 1) and mcr-1.5 (n = 1), which each differ from mcr-1 by encoding single amino acid variations. Genes from the mcr-3 family were found in isolates from Thailand, including mcr-3.1 (n = 3) and mcr-3.2 (n = 1). An E. coli isolated from a patient with a urinary tract infection in Colombia contained the recently discovered mcr-5. The full colistin-resistant collection was tested against a panel of antimicrobial agents with ceftazidime-avibactam and tigecycline exhibiting the highest activity.

show abstract

Section: Resultsmentioning

confidence: 90%

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Wise¹,

Estabrook²,

Sahm³

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In Singapore, mcr-1 has been detected in both carbapenemase-producing and carbapenem-susceptible Enterobacteriaceae . (Liu et al, 2016 ; Teo et al, 2016c , b ). Though current mcr-1 prevalence rates are a low of <3%, similar to global prevalence rates (Liassine et al, 2016 ; Saly et al, 2017 ), it remains to be seen if the rates continue to persist in this range.…”

Section: Evolution Of Resistance and Hospital-acquired-infections (Hamentioning

confidence: 99%

Klebsiella pneumoniae in Singapore: Hypervirulent Infections and the Carbapenemase Threat

Chew

Lin

Teo

2017

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Klebsiella pneumoniae remains a major pathogen responsible for localized infections such as cystitis and pneumonia, and disseminated infections that may result in severe sepsis and death. Invasive disease such as liver abscesses and endogenous endophthalmitis are associated with capsular serotypes K1 and K2. These infections require a prolonged course of antimicrobial treatment which has evolved over the years from inpatient treatment to outpatient parenteral antibiotic therapy. The emergence of plasmid-mediated resistance began with extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases. This was followed by carbapenemase genes and now plasmid transmissible colistin resistance (mcr), thus limiting viable treatment options. Plasmid-mediated carbapenemase production in Singapore was first reported in 1996. Carbapenemase production has since become the predominant mechanism of carbapenem resistance and incidence rates continue to increase over time. Although carbapenemases can occur in all Enterobacteriaceae, K. pneumoniae are the most common carrier of carbapenemase genes. Alternative treatment options are urgently required before the simplest infections, let alone invasive infections are left potentially untreatable. Clinical management requires guidance from robust laboratory testing methods to optimize patient outcomes. We explore past and present trends in treatment of K. pneumoniae infections, and discuss future treatment options and gaps in knowledge for further study.

show abstract

“…In humans, the earliest identified mcr-1 was found in a Shigella sonnei isolate arising from a hospitalized child with diarrhea in Vietnam in 2008 141 . Bacteria harboring mcr-1 have also been reported in isolates from humans (both infected patients and asymptomatic human carriers) in Canada 142 , 143 , China 108 , 136 , 144 – 154 , Denmark 106 , 140 , Ecuador 155 , Egypt 156 , France 130 , 157 , Germany 137 , 158 , 159 , Hong Kong 159 , 160 , India 161 , 162 , Italy 159 , 163 – 165 , Laos 130 , Malaysia 159 , 166 , Netherlands 131 , 167 – 170 , Norway 171 , Poland 159 , 172 , Portugal 173 , Russia 159 , Saudi Arabia 174 , Singapore 175 , 176 , South Africa 177 , 178 , Spain 159 , 179 , Sweden 180 , 181 , Switzerland 182 – 185 , Taiwan 186 , Thailand 130 , 187 , United Arab Emirates 174 , UK 188 , US 159 , 189 – 191 , Venezuela 192 , and Vietnam 141 ,…”

Section: Colistinmentioning

confidence: 99%

“…The gene has evidently been widely disseminated geographically, as well as across multiple bacterial species of differing origins. Thus far, mcr-1 has mostly been reported in E. coli , although mcr-1 -positive Citrobacter 224 , 225 , Klebsiella 108 , 157 , 175 , 224 , Shigella 141 , Enterobacter 144 , 160 , 176 , 224 , and Salmonella 129 , 135 , 136 , 173 , 188 , 195 , 208 , 211 , 217 spp. have also been documented.…”

Section: Colistinmentioning

confidence: 99%

Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin

Webb

Angulo

Granier³

et al. 2017

F1000Res

View full text Add to dashboard Cite

Use, overuse, and misuse of antimicrobials contributes to selection and dissemination of bacterial resistance determinants that may be transferred to humans and constitute a global public health concern. Because of the continued emergence and expansion of antimicrobial resistance, combined with the lack of novel antimicrobial agents, efforts are underway to preserve the efficacy of current available life-saving antimicrobials in humans. As a result, uses of medically important antimicrobials in food animal production have generated debate and led to calls to reduce both antimicrobial use and the need for use. This manuscript, commissioned by the World Health Organization (WHO) to help inform the development of the WHO guidelines on the use of medically important antimicrobials in food animals, includes three illustrations of antimicrobial use in food animal production that has contributed to the selection—and subsequent transfer—of resistance determinants from food animals to humans. Herein, antimicrobial use and the epidemiology of bacterial resistance are described for streptothricins, glycopeptides, and colistin. Taken together, these historical and current narratives reinforce the need for actions that will preserve the efficacy of antimicrobials.

show abstract

mcr-1 in Multidrug-Resistant bla _KPC-2 -Producing Clinical Enterobacteriaceae Isolates in Singapore

Cited by 30 publications

References 13 publications

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Klebsiella pneumoniae in Singapore: Hypervirulent Infections and the Carbapenemase Threat

Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin

Contact Info

Product

Resources

About

mcr-1 in Multidrug-Resistant bla KPC-2 -Producing Clinical Enterobacteriaceae Isolates in Singapore

Cited by 30 publications

References 13 publications

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program

Klebsiella pneumoniae in Singapore: Hypervirulent Infections and the Carbapenemase Threat

Illustrative examples of probable transfer of resistance determinants from food animals to humans: Streptothricins, glycopeptides, and colistin

Contact Info

Product

Resources

About

mcr-1 in Multidrug-Resistant bla _KPC-2 -Producing Clinical Enterobacteriaceae Isolates in Singapore