Macrocyclic 22,24,25-trimethyl-8,11,14-trioxa-25-azatetracyclo[19.3.1.02,7.015,20]pentacosa-2,4,6,15 (20),16,18-hexaen-23-one obtained by a Petrenko–Kritchenko condensation of 1,5-bis(2-formylphenoxy)-3-oxapentane, pentan-3-one and methylammonium acetate has been studied by X-ray structural analysis.