MiR-29
and
MiR-140
regulate TRAIL-induced drug tolerance in lung cancer
Suyeon Kim,
Ki Wook Lee,
Yongjin Yoo
et al.
Abstract:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has chemotherapeutic potential as a regulator of an extrinsic apoptotic ligand, but its effect as a drug is limited by innate and acquired resistance. Recent findings suggest that an intermediate drug tolerance could mediate acquired resistance, which has made the main obstacle for limited utility of TRAIL as an anti-cancer therapeutics. We propose miRNA-dependent epigenetic modification drives the drug tolerant state in TRAIL-induced drug toleran… Show more
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