2009
DOI: 10.1083/jcb.200807026
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miR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos

Abstract: MicroRNAs (miRNAs) are highly conserved small RNAs that act as translational regulators of gene expression, exerting their influence by selectively targeting mRNAs bearing complementary sequence elements. These RNAs function in diverse aspects of animal development and physiology. Because of an ability to act as rapid responders at the level of translation, miRNAs may also influence stress response. In this study, we show that the miR-8 family of miRNAs regulates osmoregulation in zebrafish embryos. Ionocytes,… Show more

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Cited by 111 publications
(86 citation statements)
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References 78 publications
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“…Zebrafish HR cells are mitochondria-rich cells [28,46] that perform energy-consuming tasks, such as secretion of metabolic acid and sodium uptake, to maintain internal homeostasis under regular and harsh environments [27,28,31,46,47]. These features of HR cells are consistent with those of tissues in which ERRa is predominantly expressed.…”
Section: Discussionsupporting
confidence: 66%
“…Zebrafish HR cells are mitochondria-rich cells [28,46] that perform energy-consuming tasks, such as secretion of metabolic acid and sodium uptake, to maintain internal homeostasis under regular and harsh environments [27,28,31,46,47]. These features of HR cells are consistent with those of tissues in which ERRa is predominantly expressed.…”
Section: Discussionsupporting
confidence: 66%
“…exposure to moderately acidic media (pH 5; measured as Na + -green visualization), which appeared to be a result of znherf1 overexpression (Flynt et al, 2009). While the specific Na + transporter being targeted was not addressed by Flynt et al (Flynt et al, 2009), their work provided interesting insight into the intracellular signalling within the HRC in response to acid exposure.…”
Section: Effects Of Acid Exposure On Cell Proliferationmentioning
confidence: 99%
“…While the specific Na + transporter being targeted was not addressed by Flynt et al (Flynt et al, 2009), their work provided interesting insight into the intracellular signalling within the HRC in response to acid exposure.…”
Section: Effects Of Acid Exposure On Cell Proliferationmentioning
confidence: 99%
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“…In animals, the pairings are usually imperfect and typically result in translation inhibition and/or mRNA destabilization (Chekulaeva and Filipowicz, 2009;Filipowicz et al, 2008). miRNAs play crucial roles in differentiation, cell specification, proliferation and the response to stress, but the exact function of many individual miRNAs remains to be elucidated (Ambros, 2004;Flynt et al, 2007;Flynt et al, 2009;Hatfield et al, 2005;Liu and Olson, 2010;Shkumatava et al, 2009;Takacs and Giraldez, 2010). In part, this is because of the imperfect pairing with target mRNAs, which complicates the identification of bona fide targets given the large number of possible pairing interactions.…”
mentioning
confidence: 99%