Morinda Citrifolia(Noni) Reduces Cancer Risk in Current Smokers by Decreasing Aromatic DNA Adducts

Abstract

Quantitative determination of aromatic DNA adducts in peripheral blood lymphocytes (PBLs) of current smokers is an useful surrogate biomarker for the evaluation of environmental carcinogen exposure or chemopreventive intervention. In this study, we examined the impact of Tahitian Noni Juice (TNJ) on the aromatic DNA adducts of PBLs, before and after a 1-mo intervention, using (32)P postlabeling assay. Of 283 enrolled, 203 smokers completed the trial. Aromatic DNA adducts levels in all participants were significantly reduced by 44.9% (P < 0.001) after drinking 1 to 4 oz of TNJ for 1 mo. Dose-dependent analyses of aromatic DNA adduct levels showed reductions of 49.7% (P < 0.001) in the 1-oz TNJ group and 37.6% (P < 0.001) in the 4-oz TNJ group. Gender-specific analyses resulted in no significant differences in the 4-oz TNJ groups. Interestingly, the 1-oz TNJ group showed a reduction of 43.1% (P < 0.001) in females compared with 56.1% (P < 0.001) in males. The results suggest that drinking 1 to 4 oz of TNJ daily may reduce the cancer risk in heavy cigarette smokers by blocking carcinogen-DNA binding or excising DNA adducts from genomic DNA.

Chemoprotective Effect of Noni (Morinda Citrifolia L.) Fruit Juice Against Cisplatin-Induced Nephrotoxicity

“…Overall they suggest that NJ reduces the adverse effects of NMU carcinogenesis by antioxidant properties [49]. The result of the present study is in accordance with the aforesaid study [48] and [49].…”

“…Reported that NJ has a high antioxidant potential along with cytotoxic activity on cancer cells. Consuming 1 to 4 oz (1 oz = 30 ml) of Tahitian Noni Juice (TNJ) daily may reduce the cancer risk in heavy cigarette smokers by blocking carcinogen-DNA binding [48]. Mani and their colleagues reported that NJ treatment significantly increased antioxidant enzymes levels such as CAT, SOD and significantly decreased LPO level in liver and kidney tissues when compared to n-methyl-n-nitrosourea (NMU) induced mammary carcinogenesis in Sprague-Dawley rats.…”

Nutrient and phytochemical analyses of processed noni puree

“…Noni fruit juice has also been shown to protect DNA against chemical mutagens in vivo and in a human clinical trial (Wang & Su, 2001;Wang, Peng, et al, 2009). Therefore, the anti-genotoxic activities of the iridoids were evaluated in vitro to investigate their potential roles in this reported DNA protection.…”

Super Fruits: Pomegranate, Wolfberry, Aronia (Chokeberry), Acai, Noni, and Amla

“…Consumption of 1-4 oz of TNJ for a month has been reported to significantly reduce the aromatic DNA adduct levels in smokers (Wang et al 2009). Anthraquinones present in noni root have been isolated and studied for their anticancer properties against colon cancer in humans (Kamiya et al 2009).…”