<i>Moringa oleifera</i>: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases

Ghimire, Saurav; Subedi, Lalita; Acharya, Namrata; Gaire, Bhakta Prasad

doi:10.1021/acs.jafc.1c04581

Cited by 35 publications

(24 citation statements)

References 139 publications

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“…Moreover, a recent study also showed that Niazimicin, one of MO’s active components, has a neuroprotective effect via decreasing malondialdehyde, cholinesterase, nitric oxide, Aβ, caspase-3, and inducible nitric oxide synthase enzymes [ 27 ]. Other components of MO such as ferulic acid, quercetin, and linalool have been demonstrated to exert neuroprotective effects [ 130 , 131 , 132 ].…”

Section: Discussionmentioning

confidence: 99%

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

et al. 2022

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Alzheimer’s disease is a global public health problem and the most common form of dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and Tau, and the multifactorial etiology of AD, there is now more and more interest in nutraceutical agents with multiple effects such as Moringa oleifera (MO) that have strong anti-oxidative, anti-inflammatory, anticholinesterase, and neuroprotective virtues. In this study, we treated APP/PS1 mice with a methanolic extract of MO for four months and evaluated its effect on AD-related pathology in these mice using a multitude of behavioral, biochemical, and histochemical tests. Our data revealed that MO improved behavioral deficits such as anxiety-like behavior and hyperactivity and cognitive, learning, and memory impairments. MO treatment abrogated the Aβ burden to wild-type control mice levels via decreasing BACE1 and AEP and upregulating IDE, NEP, and LRP1 protein levels. Moreover, MO improved synaptic plasticity by improving the decreased GluN2B phosphorylation, the synapse-related proteins PSD95 and synapsin1 levels, the quantity and quality of dendritic spines, and neurodegeneration in the treated mice. MO is a nutraceutical agent with promising therapeutic potential that can be used in the management of AD and other neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

et al. 2022

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“…[4,5,[228][229][230]. Now, natural products from plants and/or animals are vigorously researched into as potential therapeutics for NDDs, as current drugs have so far not been very effective in treating such diseases [5,8,231,232].…”

Section: Neuroprotective Effectmentioning

confidence: 99%

“…[ 4 , 5 , 228 , 229 , 230 ]. Now, natural products from plants and/or animals are vigorously researched into as potential therapeutics for NDDs, as current drugs have so far not been very effective in treating such diseases [ 5 , 8 , 231 , 232 ]. A recent review has pointed out the role and effectiveness of plant-based medicines due to their phytochemical constituents [ 231 ].…”

Section: Mechanism Of Cardio- and Neuroprotective Effectmentioning

confidence: 99%

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

et al. 2022

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Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that affect the nervous system and heart, all of which are vital to the human body. To maintain health of the human body, vegetable diets serve as a preventive approach and particularly Brassica vegetables have been associated with lower risks of chronic diseases, especially NDDs and CVDs. Interestingly, glucosinolates (GLs) and isothiocyanates (ITCs) are phytochemicals that are mostly found in the Cruciferae family and they have been largely documented as antioxidants contributing to both cardio- and neuroprotective effects. The hydrolytic breakdown of GLs into ITCs such as sulforaphane (SFN), phenylethyl ITC (PEITC), moringin (MG), erucin (ER), and allyl ITC (AITC) has been recognized to exert significant effects with regards to cardio- and neuroprotection. From past in vivo and/or in vitro studies, those phytochemicals have displayed the ability to mitigate the adverse effects of reactive oxidation species (ROS), inflammation, and apoptosis, which are the primary causes of CVDs and NDDs. This review focuses on the protective effects of those GL-derived ITCs, featuring their beneficial effects and the mechanisms behind those effects in CVDs and NDDs.

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“…Quercetin and kaempferol derivatives are the main polyphenols in Moringa oleifera leaves. Many studies have reported that these two kinds of compounds have neuroprotective effects [89,90]. What is worth considering is whether these two kinds of compounds play a major role in the neuroprotective effect of polyphenols in Moringa oleifera leaves.…”

Section: Effect Of Polyphenols In Mlpe Against H 2 O 2 -Induced Oxidative Stress In Pc-12 Neuroblastoma Cellsmentioning

confidence: 99%

Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves

et al. 2022

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Moringa oleifera leaves have been widely used for the treatment of inflammation, diabetes, high blood pressure, and other diseases, due to being rich in polyphenols. The main objective of this work was to largely separate the main polyphenols from Moringa oleifera leaves using the technique of high-speed counter-current chromatography (HSCCC). The phenolic composition in Moringa oleifera leaves was first analyzed qualitatively and quantitatively by UPLC-Q-Exactive Orbitrap/MS and UPLC-QqQ/MS, respectively, indicating that quercetin and kaempferol derivatives, phenolic acid and apigenin are the main polyphenols in Moringa oleifera leaves, with quercetin and kaempferol derivatives predominating. Furthermore, the conditions of HSCCC for large-scale separation of polyphenols from Moringa oleifera leaves were optimized, which included the selection of the solvent system, flow rate and the sample load. Only by one-step HSCCC separation (within 120 min) under the optimized conditions, six quercetin and kaempferol derivatives, a phenolic acid and an apigenin could be individually isolated at a large scale (yield from 10% to 98%), each of which possessed high purity. Finally, the isolated polyphenols and phenolic extract from Moringa oleifera leaves (MLPE) were verified to have strong neuroprotective activities against H2O2-induced oxidative stress in PC-12 cells, suggesting that these compounds would contribute to the main beneficial effects of Moringa oleifera leaves.

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Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases

Cited by 35 publications

References 139 publications

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases

Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves

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