Moringa oleifera
 and Autophagy: Evidence from
 In Vitro
 Studies on Chaperone-Mediated Autophagy in HepG
 2
 Cancer Cells

Bopape, Matlola; Tiloke, Charlette; Ntsapi, Claudia

doi:10.1080/01635581.2023.2270215

Cited by 3 publications

(1 citation statement)

References 212 publications

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“…Another major pathway of protein degradation is chaperon-mediated autophagy. This selectively transports proteins to the lysosomes for degradation ( 61 ). HBXIP is also involved in this pathway.…”

Section: Hbxip and Tumorsmentioning

confidence: 99%

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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Hepatitis B X-interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post-transcription and post-translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.

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Section: Hbxip and Tumorsmentioning

confidence: 99%

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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Phytochemical Analysis and Cytotoxic Effects of Phyllanthus polygonoides Leaf Extracts on Hepatocellular Carcinoma: A Combined In-Vitro and In-Silico Approach

Khalid,

Akram,

Afzal

et al. 2024

Preprint

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Hepatocellular carcinoma (HCC) is the most prevalent kind of liver cancer and a leading cause of cancer-related deaths worldwide. Treatment resistance and adverse effects often render HCC worse. With an emphasis on phytochemical analysis, antioxidant activity, and cytotoxic effects, this study investigates the possible anticancer characteristics of leaf extracts from Phyllanthus polygonoides. The methanolic extract showed considerable antioxidant activity by DPPH scavenging and notable cytotoxic effects in MTT tests. It also included flavonoids, phenols, tannins, alkaloids, quinones, and cardiac glycosides. The extract's capacity to fight cancer was validated using a wound-healing experiment. 25 phytocompounds were found using gas chromatography-mass spectrometry (GC-MS). Eight of the bioactive compounds were chosen for molecular docking based on toxicity and druggability criteria. Tests for hemolytic potential using human erythrocytes revealed significant anti-hemolytic action. Using Fourier-Transform Infrared Spectroscopy (FTIR), functional groups such as carboxylic acids, alcohols, amides, and phenols were identified. Strong binding affinities of important drugs were shown by molecular docking experiments, which were corroborated by positive ADMET profiles. By identifying active chemicals and pertinent signaling pathways, the study demonstrates the multi-target effects of P. polygonoides on HCC through the use of network pharmacology, molecular docking, and molecular dynamics simulations. These results point to the potential benefits of P. polygonoides phytochemicals as potential treatments for liver cancer and call for more research.

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Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

Albahri,

Badran,

Abdel Baki

et al. 2024

Pharmaceuticals

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Globally, cancer is one of the primary causes of both morbidity and mortality. To prevent cancer from getting worse, more targeted and efficient treatment plans must be developed immediately. Recent research has demonstrated the benefits of natural products for several illnesses, and these products have played a significant role in the development of novel treatments whose bioactive components serve as both chemotherapeutic and chemo-preventive agents. Phytochemicals are naturally occurring molecules obtained from plants that have potential applications in both cancer therapy and the development of new medications. These phytochemicals function by regulating the molecular pathways connected to the onset and progression of cancer. Among the specific methods are immune system control, inducing cell cycle arrest and apoptosis, preventing proliferation, raising antioxidant status, and inactivating carcinogens. A thorough literature review was conducted using Google Scholar, PubMed, Scopus, Google Patent, Patent Scope, and US Patent to obtain the data. To provide an overview of the anticancer effects of several medicinal plants, including Annona muricata, Arctium lappa, Arum palaestinum, Cannabis sativa, Catharanthus roseus, Curcuma longa, Glycyrrhiza glabra, Hibiscus, Kalanchoe blossfeldiana, Moringa oleifera, Nerium oleander, Silybum marianum, Taraxacum officinale, Urtica dioica, Withania somnifera L., their availability, classification, active components, pharmacological activities, signaling mechanisms, and potential side effects against the most common cancer types were explored.

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Moringa oleifera and Autophagy: Evidence from In Vitro Studies on Chaperone-Mediated Autophagy in HepG ₂ Cancer Cells

Cited by 3 publications

References 212 publications

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Phytochemical Analysis and Cytotoxic Effects of Phyllanthus polygonoides Leaf Extracts on Hepatocellular Carcinoma: A Combined In-Vitro and In-Silico Approach

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

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Moringa oleifera and Autophagy: Evidence from In Vitro Studies on Chaperone-Mediated Autophagy in HepG 2 Cancer Cells

Cited by 3 publications

References 212 publications

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Phytochemical Analysis and Cytotoxic Effects of Phyllanthus polygonoides Leaf Extracts on Hepatocellular Carcinoma: A Combined In-Vitro and In-Silico Approach

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

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Product

Resources

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Moringa oleifera and Autophagy: Evidence from In Vitro Studies on Chaperone-Mediated Autophagy in HepG ₂ Cancer Cells