Morus alba L. Leaves-Based Silver Nanoparticles for Aging-Related Infectious Diseases

Abstract

Objectives: One of the most common types of aging-related diseases is infection for which ample medications are available, and most antibacterial agents are ineffective as drug resistance spreads globally. Design: An original study. Setting(s): Batman University, Batman, Turkiye. Outcome measures: The presence of silver nanoparticles was analyzed with their maximum wavelength absorbance. Morphological appearances and distributions of synthesized nanoparticles were evaluated using transmissive electron microscope (TEM) and atomic power microscopy, respectively. The crystal patterns and sizes of nanoparticles were determined using an X-ray diffraction (XRD) instrument, and the crystal nanosizes were calculated by the DebyeScherrer equation. Minimum inhibition concentrations (MICs) were used for identifying an antibacterial effect on Gram-positive and Gram-negative strains of the bacteria Staphylococcus aureus ATCC 29213 and Escherichia coli ATCC 25922. Results: The Malatya Orduzu region provided the leaves of the Morus alba L. plant used in this study. The resulting extract was used to create silver nanoparticles. The outcomes of several microscopic and spectroscopic analyses were used to evaluate the properties of silver nanoparticles. Conclusions: Morus alba L. leaves were used to create silver nanoparticles (Ma-AgNPs), which had a size distribution below 100 nm and a maximum absorbance of 457.92 nm. Ma-AgNP’s antibacterial activity was used for pathogen gram-positive and gram-negative bacteria.