<i>MSF</i>
            (MLL septin-like fusion), a fusion partner gene of
            <i>MLL,</i>
            in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

Osaka, Mariko; Rowley, Janet D.; Zeleznik‐Le, Nancy J.

doi:10.1073/pnas.96.11.6428

Cited by 162 publications

(160 citation statements)

References 56 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…The first clues to the role of septins in neoplasia came from the observation that balanced translocations involving septin loci and the MLL locus on chromosome 11 were seen in leukaemia giving rise to chimeric fusion proteins where the N terminus of MLL was fused, in frame, to almost the entire open reading frame of SEPT9 (Osaka et al, 1999). Subsequently, it has been found that three other septins (SEPT5, SEPT6 and SEPT11) can form very similar fusion proteins with MLL again with the N-terminal moiety of MLL fused to almost the entire open reading frame of the partner septin (Taki et al, 1999;Ono et al, 2002;Kojima et al, 2004).…”

Section: Septins and Cancer Septins: The Mll Connectionmentioning

confidence: 99%

Do septins have a role in cancer?

Russell

Hall

2005

Br J Cancer

View full text Add to dashboard Cite

Septins are an evolutionarily conserved family of genes that encode a P loop-based GTP-binding domain flanked by a polybasic domain and (usually) a coiled-coil region. They have roles in cytokinesis, vesicle trafficking, polarity determination, and can form membrane diffusion barriers, as well as in microtubule and actin dynamics. Septins can form hetero-oligomeric complexes and possibly function as dynamic protein scaffolds. Recently, it has been shown that there are at least 13 human septin genes that exhibit extensive alternate splicing. There are complex patterns of human septin gene expression and recently it has been found that alterations in septin expression are seen in human diseases including neoplasia. This review summarises the essential properties of septins and outlines the accumulating evidence for their involvement in human neoplasia. Septins may belong to the class of cancer critical genes where alteration in expression profile (including alterations in the spectrum of transcripts expressed) may underpin their role in neoplasia as opposed to specific mutational events.

show abstract

Section: Septins and Cancer Septins: The Mll Connectionmentioning

confidence: 99%

Do septins have a role in cancer?

Russell

Hall

2005

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Rk Expression GAN Description Possible function/relation to Leukemia 4 AML > ALL U59632 Cell division control related hCDCrel-1 is a partner protein (hCDCrel-1) gene of MLL in some leukemias (Osaka, 1999). mRNA 3 AML > ALL U82759 GB DEF = Homeodomain Hoxa9 collaborates with other genes to produce protein HoxA9 mRNA highly aggressive acute leukemic disease (Thorsteinsdottir, 1999).…”

Section: C> N T62947 60s Ribosomal Protein L24mentioning

confidence: 99%

Untitled

Guyon¹,

Weston²,

Barnhill³

et al. 2002

Machine Learning

7,745

1,340

View full text Add to dashboard Cite

Abstract. DNA micro-arrays now permit scientists to screen thousands of genes simultaneously and determine whether those genes are active, hyperactive or silent in normal or cancerous tissue. Because these new micro-array devices generate bewildering amounts of raw data, new analytical methods must be developed to sort out whether cancer tissues have distinctive signatures of gene expression over normal tissues or other types of cancer tissues.In this paper, we address the problem of selection of a small subset of genes from broad patterns of gene expression data, recorded on DNA micro-arrays. Using available training examples from cancer and normal patients, we build a classifier suitable for genetic diagnosis, as well as drug discovery. Previous attempts to address this problem select genes with correlation techniques. We propose a new method of gene selection utilizing Support Vector Machine methods based on Recursive Feature Elimination (RFE). We demonstrate experimentally that the genes selected by our techniques yield better classification performance and are biologically relevant to cancer.In contrast with the baseline method, our method eliminates gene redundancy automatically and yields better and more compact gene subsets. In patients with leukemia our method discovered 2 genes that yield zero leaveone-out error, while 64 genes are necessary for the baseline method to get the best result (one leave-one-out error). In the colon cancer database, using only 4 genes our method is 98% accurate, while the baseline method is only 86% accurate.

show abstract

“…This translocation has been identified as fusing the MLL gene on chromosome 11q23 to either the AF17q25 gene or to MSF, both located on 17q25 and differing by a single base. [31][32][33] Since the MLL gene is known to activate several HOX genes, 34 it is tempting to speculate that the fusion protein may activate BP1 in this case.…”

Section: Figurementioning

confidence: 99%

BP1, a new homeobox gene, is frequently expressed in acute leukemias

Haga

et al. 2000

Leukemia

View full text Add to dashboard Cite

Aberrant expression of homeobox genes has been described in primary leukemia blasts. We recently cloned a new cDNA, BP1, which is a member of the homeobox gene family. BP1 expression was investigated in bone marrow samples from acute myeloid leukemia (AML), acute T cell lymphocytic leukemia (ALL) and pre-B cell ALL. Expression levels of two apparent isoforms of BP1, DLX7 and DLX4, were measured in the same samples. They are weakly if at all detectable in normal bone marrow, PHA-stimulated T cells or B cells. BP1 RNA was highly expressed in 63% of AML cases, including 81% of the pediatric and 47% of the adult cases, and in 32% of T-ALL cases, but was not found in any of the pre-B ALL cases. Coexpression of BP1, DLX7 and DLX4 occurred in a significant number of leukemias. Our data, including co-expression of BP1 with c-myb and GATA-1, markers of early progenitors, suggest that BP1 expression occurs in primitive cells in AML. Analysis of CD34 + and CD34 − normal bone marrow cells revealed BP1 is expressed in CD34 − cells and virtually extinguished in CD34 + cells. Ectopic expression of BP1 in the leukemia cell line K562 increased clonogenicity, consistent with a role for BP1 in leukemogenesis. The presence of BP1 RNA in leukemic blasts may therefore be a molecular marker for primitive cells and/or may indicate that BP1 is an important upstream factor in an oncogenic pathway.

show abstract

MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)

Cited by 162 publications

References 56 publications

Do septins have a role in cancer?

Do septins have a role in cancer?

Untitled

BP1, a new homeobox gene, is frequently expressed in acute leukemias

Contact Info

Product

Resources

About