<i>MTHFR</i> regulatory effects on methylation of CG05575921 in response to smoking: Effects are also discernable using <i>MTHFR</i> expression

Beach, Steven R. H.; Lei, Man‐Kit; Simons, Ronald L.; Dogan, Meeshanthini V.; Gibbons, Frederick X.; Philibert, Robert A.

doi:10.1002/ajmg.b.32624

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The differences between an individual's predicted and chronological age indicate, in years, the extent to which they are experiencing accelerated or decelerated aging. Details regarding the preparation of mRNA data are described in the online supplemental materials (see Beach et al, 2018, andSimons et al, 2019, for more details).…”

Section: Accelerated Mrna Agementioning

confidence: 99%

Childhood adversity and adult health: A dyadic analysis of Black American couples.

Zhang¹,

Lei²,

Simons³

et al. 2022

Health Psychology

Self Cite

View full text Add to dashboard Cite

Objective: The association between childhood adversity and adulthood health is well established, but few studies have examined potential effects of childhood adversity on partner health in couples. This study examined the long-term health impact of childhood adversity on individuals as well as their significant others. Method: The participants were 163 distinguishable dyads from the Family and Community Health Study. Health outcomes included both self-reported chronic illness and a messenger RNA index of accelerated aging. The actor-partner interdependence model with structural equation methods was used to test the hypothesis. Results: Replicating prior research, childhood adversity was associated with more chronic illness and an accelerated speed of aging. Further, participants’ health in adulthood was affected by both own and partner experiences of childhood adversity. There were no gender differences. Conclusion: Our findings replicate and extend prior research on the long-term impact of exposure to childhood adversity, suggesting that adverse childhood experiences are also harmful to romantic partners. Further studies are required to examine potential mechanisms.

show abstract

Section: Accelerated Mrna Agementioning

confidence: 99%