Abstract:Exposure to genotoxic stress by environmental agents or treatments, such as radiation therapy, can diminish health span and accelerate aging. We have developed a Drosophila melanogaster model to study the molecular effects of radiation-induced damage and repair. Utilizing a quantitative intestinal permeability assay, we performed an unbiased GWAS screen (using ~150 strains from the DGRP reference panel) to search for natural genetic variants that regulate radiation-induced gut permeability.From this screen, we… Show more
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