<i>MYC</i>gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma

Toll, Agustí; Salgado, Rocío; Yébenes, Mireia; Martín‐Ezquerra, Gemma; Gilaberte, Montserrat; Baró, Teresa; Solé, Françesc; Alameda, Francesc; Espinet, Blanca

doi:10.1111/j.1365-2133.2009.09351.x

Cited by 57 publications

(50 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding cSCC, gains and amplifications of MYC and EGFR have recently been reported by our group (Toll et al, 2009(Toll et al, , 2010 and we found that aberrations involving MYC were more frequent in moderately to poorly differentiated cSCCs than in well differentiated counterparts. In the present study, 8 of 14 cSCC with CKS1B amplification metastasized to mcSCC.…”

Section: Cks1b In Cutaneous Squamous Cell Carcinomamentioning

confidence: 65%

CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour

Salgado

Toll

Alameda

et al. 2010

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

Genetic mechanisms giving rise to the development of cutaneous squamous cell carcinoma (cSCC) are poorly understood and development of genomic high resolution techniques has led to a better knowledge of the genetic basis of several human cancers. In this study, 16 cSCC were analyzed using array comparative genomic hybridization (arrayCGH). The most common aberrations found were gains of 3q11q13, 1q21.3q25, 13q34, and 19p13, and losses of 1p36p31, 3p24p21, 10p15q22, and 13q11q21. We detected gains (3/16) and amplification (1/16) of the 1q21.1q21.3 region. A potential candidate gene in this region, CKS1B (1q21.2), was selected for validation in an independent cohort and correlations with clinicopathological features were carried out. CKS1B gene and protein status were analyzed using fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) in a series of 53 cSCC, 22 actinic keratoses (AK), and 10 normal skin samples. cSCC presented a higher frequency of chromosome 1 polysomy than AK (70% vs. 46%, P = 0.047). Association between CKS1B protein overexpression and both polysomy and amplification was demonstrated in cSCC (P < 0.001). Regarding amplifications, 11 cSCC patients (21%) presented CKS1B gene amplification. Interestingly, 8/11 (73%) patients who showed a CKS1B amplification had presented metastatic spread (mcSCC). Differences between the presence of CKS1B amplification and the presence or absence of mcSCC were observed (mcSCC [8/14] vs. cSCC [3/39]) (P < 0.001). Several drugs targeting CKS1B have been reported and may be useful for treating patients with cSCC and CKS1B amplifications.

show abstract

Section: Cks1b In Cutaneous Squamous Cell Carcinomamentioning

confidence: 65%

CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour

Salgado

Toll

Alameda

et al. 2010

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

show abstract

“…11,12 They seem to have a relevant role in the biological behavior of several carcinomas. Frequent integration of HPV at 8q24 in cervical carcinoma cell lines has also been reported.…”

mentioning

confidence: 99%

MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma

Masferrer

Ferrándiz-Pulido

Lloveras³

et al. 2012

Journal of Urology

View full text Add to dashboard Cite

show abstract

“…Additional molecular events associated with AK formation include increased activation or levels of SFKs, EGFR, Myc, and ATF-3 (30)(31)(32)(33). In addition, decreased levels of inositol polyphosphate 5′-phosphatase have also been reported in AKs, which could result in increased PI3K/Akt signaling (34).…”

Section: Introductionmentioning

confidence: 99%

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma

Ratushny

Gober²,

Hick³

et al. 2012

J. Clin. Invest.

489

477

View full text Add to dashboard Cite

Cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with over 250,000 new cases annually in the US and is second in incidence only to basal cell carcinoma. cSCC typically manifests as a spectrum of progressively advanced malignancies, ranging from a precursor actinic keratosis (AK) to squamous cell carcinoma (SCC) in situ (SCCIS), invasive cSCC, and finally metastatic SCC. In this Review we discuss clinical and molecular parameters used to define this range of cutaneous neoplasia and integrate these with the multiple experimental approaches used to study this disease. Insights gained from modeling cSCCs have suggested innovative therapeutic targets for treating these lesions.

show abstract

MYCgene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma

Abstract: MYC gains and amplifications are frequent cytogenetic abnormalities in SCCs and may play a relevant role in promoting SCC undifferentiation and tumoral progression.

Cited by 57 publications

References 21 publications

CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour

CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour

MYC Copy Number Gains are Associated with Poor Outcome in Penile Squamous Cell Carcinoma

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma

Contact Info

Product

Resources

About