<i>Mycobacterium bovis</i>epidural abscess following Bacillus Calmette-Guerin therapy for bladder cancer

Jain, Hanish; Gada, Kunal; Zaidi, Syed; Asiago-Reddy, Elizabeth; Eranki, Ambika

doi:10.1080/08998280.2019.1647714

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…A literature review of Mycobacterium causing an epidural collection discloses a number of studies reporting both typical ( M. tuberculosis, M. bovis, and M. leprae ) and atypical ( M. abscessus, M. avium-intracellulare, and M. fortuitum ) Mycobacterium causing epidural abscesses. In some cases, the epidural abscess extended into neighboring bone, intervertebral disc, and paraspinal and psoas musculature [ 10 , 13 , 14 ], while in others, adjacent osseous and soft tissue structures were not reported to be involved [ 15 - 17 ]. As mentioned in Introduction, only one other case of an isolated M. abscessus epidural abscess has been reported.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Osteomyelitis Caused by Mycobacterium abscessus Necessitating Surgical Decompression and Revision Surgery With Interbody Fusion

Bashti¹,

Kumar²,

Côté³

et al. 2023

Cureus

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Epidural abscesses can be caused by a number of different organisms, including atypical Mycobacterium. This is a rare case report of an atypical Mycobacterium epidural abscess requiring surgical decompression. Here, we present Mycobacterium abscessus causing a nonpurulent epidural collection surgically treated with laminectomy and washout and discuss clinical clues and radiologic characteristics associated with this condition.A 51-year-old male with a past medical history of chronic intravenous (IV) drug use presented with a threeday history of falls and three-month history of progressively worsening bilateral lower extremity radiculopathy, paresthesias, and numbness. MRI demonstrated an enhancing collection at L2-3 ventral and to the left of the spinal canal causing severe compression of the thecal sac, along with heterogenous contrast enhancement of the L2-3 vertebral bodies and intervertebral disc. The patient was taken for an L2-3 laminectomy and left medial facetectomy, where a fibrous, nonpurulent mass was discovered. Cultures ultimately demonstrated Mycobacterium abscessus subspecies massiliense, and the patient was discharged on IV levofloxacin, azithromycin, and linezolid with complete symptomatic relief.Unfortunately, despite surgical washout and antibiotic coverage, the patient presented twice more, the first time with a recurrent epidural collection requiring repeat drainage and the second time with a recurrent epidural collection with discitis and osteomyelitis with pars fractures requiring repeat epidural drainage and interbody fusion.It is important to recognize that atypical Mycobacterium abscessus can cause a nonpurulent epidural collection, especially in high-risk patients such as those with a history of chronic IV drug use. Additionally, our initial intraoperative findings of a fibrous, adherent mass suggest that in cases where this entity is suspected, surgical decompression should be carefully considered. To this end, the radiologic findings associated with this condition, namely, an enhancing ventral epidural mass involving the disc space, should also be recognized. The notable postoperative course consisting of recurrent collections and osteomyelitis with a pars fracture suggests that early fusion should be considered as an option in these patients. This case report presents clinical and radiologic findings associated with an atypical Mycobacterium discitis and osteomyelitis. The clinical course described herein suggests that early fusion in these patients may provide superior results to decompression alone.

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