<i>Mycobacterium bovis</i>Infection, Lyon, France

Mignard, S.; Pichat, Catherine; Carret, G.

doi:10.3201/eid1209.060209

Cited by 33 publications

(28 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, none of the spoligotypes in our survey and these reports overlap. Predominant strains by spoligotype in animals and those infecting humans in the same country are known to be linked (1,13,14). We found 3 novel spoligotypes similar to SB0140 in a small group of patients, showing that a wider variety of strains infect humans than animals, as described in similar studies (1,2,13).…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Ojo¹,

Sheehan²,

Corcoran³

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

Mycobacterium bovis caused 3% of human tuberculosis cases in southwest Ireland during 1998–2006. Of 11 M. bovis strains genotyped, 9 belonged to common animal spoligotypes. Seven strains were from sputum and potential sources of human-centered disease transmission. Ten-locus variable-number tandem repeat typing gave unique strain profiles and would detect disease outbreaks.

show abstract

Section: Discussionsupporting

confidence: 80%

“…It forms the single largest group of M. bovis strains isolated from humans in the United Kingdom (30%) (1). This group was not reported in a recent series of M. bovis isolates from humans in Italy (13) or France (14). Indeed, none of the spoligotypes in our survey and these reports overlap.…”

Section: Discussioncontrasting

confidence: 63%

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Ojo¹,

Sheehan²,

Corcoran³

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Mycobacterium bovis , the main causative agent of the disease, has a broad host range, infecting different wild and domestic animals, and occasionally humans (Mignard et al , 2006). …”

mentioning

confidence: 99%

“…The presence or absence of each non-repetitive sequence creates a pattern for each strain when analyzed by spoligotyping. Spoligotyping and VNTR patterns are now considered standard techniques for the molecular typing of M. bovis (Mignard et al , 2006). …”

mentioning

confidence: 99%

Molecular typing of Mycobacterium bovis isolated in the south of Brazil

Ramos

Silva

Fagundes

et al. 2014

Braz. J. Microbiol.

View full text Add to dashboard Cite

Bovine tuberculosis is a major infectious disease of the cattle. In this study, 85 M. bovis isolates from 162 lymph nodes, obtained from a herd of cattle on a farm in southern Brazil, were evaluated using spoligotyping and VNTR. The strains were grouped into five clusters and five orphans, showing a heterogenic genetic profile, what could represent diverse geographic origins of the introduced cows and/or the frequent movement of cattle between different properties.

show abstract

“…Human tuberculosis caused by Mycobacterium bovis is infre-quent in industrialized countries (approximately 0.5 to 1.5% of all culture-positive cases of human tuberculosis) (3,6,8). In historical descriptions in Western Europe, acquisition of M. bovis by humans was mainly related to ingestion of unpasteurized milk from infected cows (3).…”

mentioning

confidence: 99%

Human-to-Human Transmission of Tuberculosis Caused by Mycobacterium bovis in Immunocompetent Patients

Sunder

Lanotte

Godreuil³

et al. 2009

J Clin Microbiol

View full text Add to dashboard Cite

Human-to-human transmission of Mycobacterium bovis in two immunocompetent patients from the same family was confirmed by spoligotyping (pattern F35, which was only observed in cattle from the same area in France). A single allelic difference between animal and human isolates was observed with mycobacterial interspersed repetitive units containing variable-number tandem repeats, suggesting a jump across the species barrier.CASE REPORTS Case 1. In April 2004, a 50-year-old man, born in France, was admitted to the Respiratory Disease Department of the Limoges Hospital for pulmonary tuberculosis. Since 1987, he had been working in a slaughterhouse and handled offal. Clinical manifestations were cough and asthenia. The chest radiograph showed a cavitation of the left upper lobe. The tuberculin skin test (TST) reaction was considered positive. Gastric aspirations were positive for acid-fast bacilli (AFB), and cultures were secondarily positive for M. bovis. M. bovis was identified by phenotyping methods, and identification was then confirmed by molecular analysis (9). The human immunodeficiency virus (HIV) antibody test was negative. Therapy consisted of an association of isoniazid (INH), rifampin (RMP), and ethambutol (EMB). Sample cultures became negative after 1 month of treatment. EMB was discontinued after 3 months; INH and RMP were continued for a total duration of 12 months. Contact tracing was performed. Only his daughter had a positive TST, but she refused any prophylactic treatment.Case 2. In May 2007, the daughter of case 1, a 20-year-old woman, born in France, was admitted to the Tours Hospital for suspicion of pulmonary tuberculosis. She had had productive cough with night sweats, thoracic pain, and asthenia for 1 month before hospitalization. The chest radiograph showed a cavitation of the left upper lobe with mediastinal adenopathy confirmed by computed tomography. Two sputum specimens and one gastric aspiration were positive for AFB. Cultures grew M. bovis. The HIV antibody test was negative. Therapy was initiated with an association of INH, RMP, and EMB and continued for 3 months. Sputum smears and culture were negative after 1 month of treatment. EMB was discontinued after 3 months of treatment, and INH and RMP were continued for a total duration of 9 months. Contact tracing was conducted and identified one contact, the patient's grandmother, whose TST reaction was positive at 20 mm. Thus, she received a regimen of INH and RMP for 3 months to treat her latent tuberculosis infection.Case 1 worked in the Limoges slaughterhouse from 1987 to 2004 and was certainly occupationally exposed during this period. On the other hand, case 2 was born after hygienic measures were applied and she had never traveled to countries where they were not applied. Moreover, she had no contact with cattle herds. Therefore, it is most likely that she was infected by her father.We compared the M. bovis strains from cases 1 and 2 using spoligotyping and mycobacterial interspersed repetitive units containing variable-number tand...

show abstract

Mycobacterium bovisInfection, Lyon, France

Cited by 33 publications

References 13 publications

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Mycobacterium bovisStrains Causing Smear-Positive Human Tuberculosis, Southwest Ireland

Molecular typing of Mycobacterium bovis isolated in the south of Brazil

Human-to-Human Transmission of Tuberculosis Caused by Mycobacterium bovis in Immunocompetent Patients

Contact Info

Product

Resources

About