Mycobacterium abscessus and Gastroesophageal Reflux: An In Vitro Study

Dawrs, Stephanie N.; Kautz, Michelle; Chan, Edward D.; Honda, Jennifer R.

doi:10.1164/rccm.202001-0011le

Cited by 13 publications

(9 citation statements)

References 8 publications

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“…To illustrate this, an in vitro study noted that M. abscessus remained viable in a human tracheobronchial epithelial cell model regardless of the acid exposure. 88 A study by Koh et al showed that 26% of those with nodular bronchiectatic NTM had GERD detected by the use of pH probes, despite only a quarter of these having typical GERD symptoms emphasizing the lack of sensitivity of symptoms. 89 Persons with conditions requiring use of high-dose inhaled corticosteroids are also at higher risk of developing NTM PD.…”

Section: Risk Factors Associated With Ntm Pulmonary Diseasementioning

confidence: 99%

Nontuberculous Mycobacteria

Kasperbauer

2021

Semin Respir Crit Care Med

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Nontuberculous mycobacteria (NTM) are ubiquitous in the environment and 193 species of NTM have been discovered thus far. NTM species vary in virulence from benign environmental organisms to difficult-to-treat human pathogens. Pulmonary infections remain the most common manifestation of NTM disease in humans and bronchiectasis continues to be a major risk factor for NTM pulmonary disease (NTM PD). This article will provide a useful introduction and framework for clinicians involved in the management of bronchiectasis and NTM. It includes an overview of the epidemiology, pathogenesis, diagnosis, and management of NTM PD. We will address the challenges faced in the diagnosis of NTM PD and the importance of subspeciation in guiding treatment and follow-up, especially in Mycobacterium abscessus infections. The treatment of both Mycobacterium avium complex and M. abscessus, the two most common NTM species known to cause disease, will be discussed in detail. Elements of the recent ATS/ERS/ESCMID/IDSA NTM guidelines published in 2020 will also be reviewed.

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Section: Risk Factors Associated With Ntm Pulmonary Diseasementioning

confidence: 99%

Nontuberculous Mycobacteria

Kasperbauer

2021

Semin Respir Crit Care Med

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“…We appreciate the congratulations offered by Ward and colleagues regarding our recent publication on the possible link between nontuberculous mycobacterial (NTM) pulmonary disease (PD) and gastroesophageal reflux disease (GERD) ( 1 ). As a basic-science laboratory dedicated to learning more about the biology, microbiology, and immunology of environmentally acquired NTM infections, the intersection of our work with gastroenterology is intriguing and timely.…”

mentioning

confidence: 99%

Reply to Ward et al.: Clonally Related Viable Nontuberculous Mycobacteria in Gastric Juice and Sputum in People with Cystic Fibrosis

Honda

2020

Am J Respir Crit Care Med

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“…We congratulate Dawrs and colleagues for their investigation of a possible link between nontuberculous mycobacterial (NTM) pulmonary infections, gastro esophageal reflux, and microaspiration ( 1 ).…”

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confidence: 99%

“…The authors hypothesize that NTM may be deposited into the lung through extra esophageal reflux and microaspiration following intake from potable water systems and environmental sources ( 1 ). The investigators used in vitro modeling approaches and pH-adjusted laboratory mycobacterial cultures to investigate the susceptibility of human airway epithelial cells to NTM infection.…”

mentioning

confidence: 99%