<i>Mycobacterium kyorinense</i>Infection

Ohnìshì, H.; Yonetani, Shota; Matsushima, Satsuki; Wada, Hiroo; Takeshita, Kei; Kuramochi, Daisuke; Caldas, Paulo César de Souza; Campos, Carlos Eduardo Dias; Costa, Bianca Porphirio da; Ramos, Jesus Pais; Mikura, Shinichirou; Narisawa, Eriko; Fujita, Akira; Funayama, Yasunori; Kobashi, Yoshihiro; Sakakibara, Yoshikazu; Ishiyama, Yukako; Takakura, Shunji; Goto, Hajime; Watanabe, Takashi

doi:10.3201/eid1903.120591

Cited by 9 publications

(15 citation statements)

References 9 publications

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“…kyorinense and M . triplex are rare manifestations which have been reported in only two or three cases so far globally and the current study also found a case of each [27, 28]. The infections caused by M .…”

Section: Discussionsupporting

confidence: 67%

Emergence of Rare Species of Nontuberculous Mycobacteria as Potential Pathogens in Saudi Arabian Clinical Setting

et al. 2017

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BackgroundClinical relevance of nontuberculous mycobacteria (NTM) is increasing worldwide including in Saudi Arabia. A high species diversity of NTM’s has been noticed in a recent study. However, the identification in diagnostic laboratories is mostly limited to common species. The impact of NTM species diversity on clinical outcome is so far neglected in most of the clinical settings.Methodology/Principal FindingsDuring April 2014 to September 2015, a nationwide collection of suspected NTM clinical isolates with clinical and demographical data were carried out. Primary identification was performed by commercial line probe assays. Isolates identified up to Mycobacterium species level by line probe assays only were included and subjected to sequencing of 16S rRNA, rpoB, hsp65 and 16S-23S ITS region genes. The sequence data were subjected to BLAST analysis in GenBank and Ez-Taxon databases. Male Saudi nationals were dominated in the study population and falling majorly into the 46–59 years age group. Pulmonary cases were 59.3% with a surprising clinical relevance of 75% based on American Thoracic Society guidelines. Among the 40.7% extra-pulmonary cases, 50% of them were skin infections. The identification revealed 16 species and all of them are reporting for the first time in Saudi Arabia. The major species obtained were Mycobacterium monascence (18.5%), M. cosmeticum (11.1%), M. kubicae (11.1%), M. duvalli (7.4%), M.terrae (7.4%) and M. triplex (7.4%). This is the first report on clinical relevance of M. kubicae, M. tusciae, M.yongonense, M. arupense and M.iranicum causing pulmonary disease and M. monascence, M. duvalli, M. perigrinum, M. insubricum, M. holsaticum and M. kyorinense causing various extra-pulmonary diseases in Saudi Arabia. Ascites caused by M. monascence and cecum infection by M. holsaticum were the rarest incidents.Conclusions/SignificanceTo the first time in the country, clinical significance of various rare NTM’s are well explored and the finding warrants a new threat to the Saudi Arabian clinical settings.

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Section: Discussionsupporting

confidence: 67%

Emergence of Rare Species of Nontuberculous Mycobacteria as Potential Pathogens in Saudi Arabian Clinical Setting

et al. 2017

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“…The sequences of these genes in M. kyorinense were compared with those in M. tuberculosis H37Rv to clarify whether they contain specific mutations associated with resistance to anti-tuberculosis drugs in M. tuberculosis . Analysis of the rpoB gene confirmed our previous finding that KUM060204 T harbors a Ser531Asp amino acid substitution, the most frequent mutation in rifampin-resistant M. tuberculosis ( 4 , 5 ). In contrast, we did not detect a substitution at Met306 of embB , the major mutation in ethambutol-resistant M. tuberculosis ( 6 ).…”

Section: Genome Announcementsupporting

confidence: 84%

“…Mycobacterium kyorinense is a slow-growing mycobacterium that was first described in 2009 ( 1 ). M. kyorinense is closely related to M. celatum , M. branderi , and M. fragae , and exhibits significant pathogenicity for humans, causing pneumonia, lymphadenitis, and arthritis ( 2 – 4 ). Antimicrobial susceptibility tests demonstrated that M. kyorinense is generally resistant to rifampin, isoniazid, and ethambutol ( 4 ).…”

Section: Genome Announcementmentioning

confidence: 99%

“…M. kyorinense is closely related to M. celatum , M. branderi , and M. fragae , and exhibits significant pathogenicity for humans, causing pneumonia, lymphadenitis, and arthritis ( 2 – 4 ). Antimicrobial susceptibility tests demonstrated that M. kyorinense is generally resistant to rifampin, isoniazid, and ethambutol ( 4 ). Further investigation is needed to clarify the genomics, biology, epidemiology, and pathogenicity of this species.…”

Section: Genome Announcementmentioning

confidence: 99%

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Whole-Genome Sequence of Mycobacterium kyorinense

et al. 2014

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“…We discuss the clinical presentation, the isolation of the organism on several specimens and initial management. M. kyorinense is a recently characterized species, which has previously only been described in Japan and Brazil [1] .…”

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confidence: 99%

Pulmonary cavitary Mycobacterium kyorinense (M. kyorinense) infection in an Australian woman

Muruganandan

Jayaram

Wong

et al. 2015

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We describe a patient with pulmonary cavitary pneumonia from whom we serially isolated Mycobacterium kyorinense, an organism not previously reported in Australia, or associated with cavitary disease. We discuss the clinical presentation, the isolation of the organism on several specimens and initial management. M. kyorinense is a recently characterized species, which has previously only been described in Japan and Brazil [1].

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Mycobacterium kyorinenseInfection

Cited by 9 publications

References 9 publications

Emergence of Rare Species of Nontuberculous Mycobacteria as Potential Pathogens in Saudi Arabian Clinical Setting

Emergence of Rare Species of Nontuberculous Mycobacteria as Potential Pathogens in Saudi Arabian Clinical Setting

Whole-Genome Sequence of Mycobacterium kyorinense

Pulmonary cavitary Mycobacterium kyorinense (M. kyorinense) infection in an Australian woman

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