<i>Mycobacterium tuberculosis</i>Growth Control by Lung Macrophages and CD8 Cells from Patient Contacts

Carranza, Claudia; Juárez, Esmeralda; Torres, Martha; Ellner, Jerrold J.; Sada, Eduardo; Schwander, Stephan

doi:10.1164/rccm.200503-411oc

Cited by 63 publications

(55 citation statements)

References 66 publications

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“…Macrophages cocultured with autologous CD8 T cells from persons with high levels of exposure to M. tuberculosis may have enhanced capacity to limit myco- bacterial growth (4). In this study, persons were recruited from a geographic region of high TB incidence, where the majority of persons have been exposed to M. tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

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HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria

Kalsdorf¹,

Scriba²,

Wood³

et al. 2009

Am J Respir Crit Care Med

142

124

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Section: Discussionmentioning

confidence: 99%

“…The mechanisms of immunity against M. tuberculosis are not completely understood (3), but control of M. tuberculosis infection depends on a T-cell immune response comprising CD4 and CD8 cells (4)(5)(6). Th1 cytokines, including IFN-g (5,7,8) and tumor necrosis factor (TNF)-a (9)(10)(11), are critical for effective immune responses.…”

mentioning

confidence: 99%

HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria

Kalsdorf¹,

Scriba²,

Wood³

et al. 2009

Am J Respir Crit Care Med

142

124

View full text Add to dashboard Cite

“…Oxidative changes to proteins due to NO can lead to diverse functional consequences such as inhibition of enzymatic activities, proteolysis and altered immunogenicity. 31 In our findings, EEPM showed significant results in preliminary phytochemical studies and in vitro free radical scavenging activity prompted us to select the ethanol extract for pharmacological screening. Behavioural tests for learning and memory, biochemical estimation results indicated that the endotoxin, LPS, leads to minimal attention capacity, decreased the short term memories in rats which were found to be reversed by EEPM when compared to control treated groups.…”

Section: In Vivo Antioxidant Activitymentioning

confidence: 74%

Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats

Swaminathan¹,

Sundaram²,

Annapandian³

et al. 2017

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1Endotoxic shock can be elicited by a systemic injection of LPS which induces the production and release of several cytokines.2 In response to these cytokines, several reactive oxygen species (ROS) are produced from cells such as neutrophils and other phagocytic cells, creating a status of oxidative stress.3 Thus, this type of stress may hypothetically support the assumption that LPSinduced cell injury would be retarded by modifying free radical metabolism with the aid of potent antioxidant pre-treatment from nature. Certain reports have claimed that a few herbal extracts can act on the central nervous system, thereby enhancing the faculties of learning and memory. 4 The . At the end of the study, rats were sacrificed, brain hippocampal region was removed and biochemical parameters were measured. Results: In WMT swimming length (cm) was increased in LPS-treated rats when compared to control animals, the swimming length (EEPM; 400 mg/kg) was found to be significant; in RAM, different doses of EEPM at 100, 200 and 400 mg/kg decreased the number of errors in entry 4.00±0.36, 4.16±0.16and 3.33±2.79 respectively when compared with control animals (2.66± 0.21). EEPM at 400 mg/kg showed significant activity, in CRT apparatus increased incorrect lever pressing was observed in LPS-treated rats when compared to control animals. Incorrect lever pressing was minimized by EEPM at 400 mg/kg (43.5±2.40). Conclusions: Our results showed that EEPM is a hopeful aspirant for hindrance of infection and inflammation induced brain damage by LPS.

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“…Although the importance of the IL-12-IFN-γ-TNF-α axis in Mtb control is well established from human and animal studies [37,38], increased levels of TNF have been found with increasing multiplicity of infection (MOI) of live Mtb in AMs and was found to positively correlate with growth of virulent Mtb (H37Rv) suggesting that TNF may contribute to immunopathology by directly supporting bacterial growth [39]. Furthermore, in studies of healthy contacts of subjects with active TB, CD4+ T cell, AM co-cultures lead to increased IFN-γ production, improved control of bacterial growth was only seen in CD8:AM co-cultures in these subjects [40]. AMs appear to release higher levels of monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) compared to blood monocytes and also express higher levels of regulated on activation normal T cell expressed and secreted (RANTES) in response to both virulent and avirulent Mtb strains [41].…”

Section: Cytokine and Chemokine Productionmentioning

confidence: 99%

The Lung Immune Niche in Tuberculosis: Insights from Studies on Human Alveolar Macrophages

Chatterjee

2015

Curr Trop Med Rep

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Tuberculosis (TB) is a disease that continues to cause global mortality and morbidity. Transmission of Mycobacterium tuberculosis (Mtb) occurs by aerosol transmission from an infected case, making the lung the primary portal of entry for the bacterium. Alveolar macrophages are the frontline cells involved in the control of subsequent replication and spread of disease. Although animal models have provided important information in the field of macrophage immunology and cell biology, human TB disease has several unique features. Therefore, an understanding of human alveolar macrophage biology and their interactions with Mtb is important, not only to understand how to address TB control at various stages of the disease but also to develop optimal future vaccination and drug strategies. Despite limitations of human sample access, technical expertise in cell processing, and access to reagents, significant advances have been made in the field providing critical insights into host-pathogen interactions This review describes the unique features and the immune responses of human alveolar macrophages in the context TB infection.

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Mycobacterium tuberculosisGrowth Control by Lung Macrophages and CD8 Cells from Patient Contacts

Cited by 63 publications

References 66 publications

HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria

HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria

Neuroprotective Effect of Pedalium murex Linn. Leaf against Lipopolysaccharide Induced Behavioural Disorders in Rats

The Lung Immune Niche in Tuberculosis: Insights from Studies on Human Alveolar Macrophages

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