<i>Mycobacterium tuberculosis</i>/HIV‐1 Coinfection and Disease: Role of Human Leukocyte Antigen Variation

Louie, Leslie; Hartogensis, Wendy; Jackman, Rachael P.; Schultz, Kathleen; Zijenah, Lynn S.; Yiu, Carina H.-Y.; Nguyen, Viet D.; Sohsman, Marie Y.; Katzenstein, David; Mason, Peter R.

doi:10.1086/382030

Cited by 27 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Considering the stage of HIV/AIDS infection at the time of testing and exposure to M. tuberculosis, several significant differences in antibody detection may be observed (33,37,42). While reports vary greatly on the effectiveness of various antigens, it is clear that additional work is necessary before accurate claims about the effectiveness of M. tuberculosis serology in HIV patients can be made.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Three Commercially Available Serologic Assays for Detection of Antibodies to Mycobacterium tuberculosis and Identification of Active Tuberculosis

Anderson

Welch

Litwin

2008

Clin Vaccine Immunol

View full text Add to dashboard Cite

Tuberculosis (TB) caused byApproximately nine million new cases of disease and over two million deaths result from tuberculosis (TB) each year (29,56). It is estimated that over one-third of the world's population is infected, with ϳ95% of all cases occurring in developing countries. Global measures attempting to reduce the transmission of TB are currently in place.An essential component of TB control efforts is to identify and treat individuals with active TB disease. The ability to correctly identify individuals with latent TB infection who will progress to active TB disease is vital to this goal (9, 49). Current test procedures are inadequate to accurately detect and identify active TB disease (14,27,30,31,41,44). These shortcomings result in the unnecessary treatment of many individuals who may not need it (3,17,32,45). While the tuberculin skin test (TST) and the QuantiFERON-TB Gold (QFT-G), the traditional methods for latent TB infection screening, rely on the cell-mediated response, the humoral response appears to correlate with the progression of the infection to active TB disease (5,6,11,15,20,21).Many studies have been conducted to evaluate the utility of individual specific Mycobacterium tuberculosis antigens for detecting antibodies in patients with active TB disease (1,7,10,11,20,21,25,26,29,38,39,45,46). Several of these antigens have been developed into commercial assays capable of detecting M. tuberculosis antibodies (4,28,35,53). This study evaluates three commercially available enzyme-linked immunosorbent assays (ELISAs) for their ability to detect immunoglobulin G (IgG) antibodies to M. tuberculosis in patients with active TB disease. MATERIALS AND METHODSHuman sera. The procedures followed were in accordance with the ethical standards established by the University of Utah and are in accordance with the Helsinki Declaration of 1975. This study was approved by the Institutional Review Board of the University of Utah, IRB 17152. All patient samples included in this study were deidentified to meet the Health Information Portability and Accountability Act (HIPAA) patient confidentiality guidelines.Serum samples were stored at Ϫ70°C until testing commenced and were then stored at 2 to 8°C while testing was performed. The whole-blood samples were processed immediately after collection. Samples with discrepant results were tested again by each respective assay to ensure reproducibility. A total of 209 samples were used and divided into four groups.Risk factors that were evaluated for exposure to TB included work in the health care field, laboratory work (especially in mycobacteriology laboratories and specimen processing), immigration from or travel to an country where TB is endemic, and exposure to persons with known active disease. Work in a mycobacteriology laboratory, exposure to a known active case, or immigration from a country where TV is endemic were considered high risk for exposure. Work in a health care field was considered moderate risk.Group I serum samples consisted of 88 samples from h...

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Three Commercially Available Serologic Assays for Detection of Antibodies to Mycobacterium tuberculosis and Identification of Active Tuberculosis

Anderson

Welch

Litwin

2008

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…For TNF ␣ , heterozygote advantage may be plausible because an intermediate level of TNF ␣ may be favored, since an overabundance of TNF ␣ is associated with severe TB pathology [16] , and defi ciency or blockage of TNF ␣ is associated with an increased risk for TB [2,18] . Anecdotal reports have suggested a role for natural selection in TB susceptibility (reviewed by Stead [48] ) and, more recently, heterozygote advantage for rapidly progressive TB disease among HIV infected individuals has been suggested [49] .…”

Section: Discussionmentioning

confidence: 99%

Evidence for a Major Gene Influence on Tumor Necrosis Factor-α Expression in Tuberculosis: Path and Segregation Analysis

et al. 2005

View full text Add to dashboard Cite

Objective: Tuberculosis (TB) is a growing global public health problem. Several studies suggest a role for host genetics in disease susceptibility, but studies to date have been inconsistent and a comprehensive genetic model has not emerged. A limitation of previous genetic studies is that they only analyzed the binary trait TB, which does not reflect disease heterogeneity. Furthermore, these studies have not accounted for the influence of shared environment within households on TB risk, which may spuriously inflate estimates of heritability. Methods: We conducted a household contact study in a TB-endemic community in Uganda. Antigen-induced tumor necrosis factor-α (TNFα) expression, a key component of the underlying immune response to TB, was used as an endophenotype for TB. Results: Path analysis, conducted to assess the effect of shared environment, suggested that TNFα is heritable (narrow sense heritability = 34–66%); the effect of shared environment is minimal (1–14%), but gene-environment interaction may be involved. Segregation analysis of TNFα suggested a major gene model that explained one-third of the phenotypic variance, and provided putative evidence of natural selection acting on this phenotype. Conclusion: Our data further support TNFα as an endophenotype for TB, as it may increase power to detect disease-predisposing loci.

show abstract

“…31 Details on specificities, primer sequences, and reaction conditions of the Cytokine CTS-PCR-SSP Tray Kit are available for IL10, TGFB1, TNF, IL4R, IL1B, IL1RN, IL1R1, IL1A, IL4, and IL6. [32][33][34] Typing results for SNP rs2243248 did not meet quality requirements for interpretation and were therefore excluded from additional analysis.…”

Section: Cytokine Genotyping and Dna Preparationmentioning

confidence: 99%

Interleukin-4 Promoter Polymorphisms: A Genetic Prognostic Factor for Survival in Metastatic Renal Cell Carcinoma

Kleinrath

Gassner

Lackner

et al. 2007

JCO

View full text Add to dashboard Cite

show abstract

Mycobacterium tuberculosis/HIV‐1 Coinfection and Disease: Role of Human Leukocyte Antigen Variation

Cited by 27 publications

References 28 publications

Assessment of Three Commercially Available Serologic Assays for Detection of Antibodies to Mycobacterium tuberculosis and Identification of Active Tuberculosis

Assessment of Three Commercially Available Serologic Assays for Detection of Antibodies to Mycobacterium tuberculosis and Identification of Active Tuberculosis

Evidence for a Major Gene Influence on Tumor Necrosis Factor-α Expression in Tuberculosis: Path and Segregation Analysis

Interleukin-4 Promoter Polymorphisms: A Genetic Prognostic Factor for Survival in Metastatic Renal Cell Carcinoma

Contact Info

Product

Resources

About